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Protein Overview: CHD1

General Information:
Name(s) found: CHD1 / YER164W [SGD]
Description(s) found:
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  • gi|6321012|ref|NP_011091.1| Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SILK complexes; Chd1p [Saccharomyces ce [NCBI NR]
  • gi|603404|gb|AAB64691.1| Chd1p: transcriptional regulator [Saccharomyces cerevisiae] [NCBI NR]
  • gi|418395|sp|P32657.1|CHD1_YEAST RecName: Full=Chromo domain-containing protein 1; AltName: Full=ATP-dependent helicase CHD1 [NCBI NR]
  • pir||S30818 hypothetical protein YER164w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Chromo domain-containing protein 1 OS=Saccharomyces cerevisiae GN=CHD1 PE=1 SV=1 [Swiss-Prot]
  • CHD1 Transcriptional regulator [mips]
  • Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes [SGD]
  • CHD1, Chr V from 505387-509793 [yeast_orfs2]
  • Chr V from 505387-509793 [yeastorf3.fasta]
  • (P32657) CHD1 protein [4932.FASTACCERV.txt]
  • CHD1 SGDID:S0000966, Chr V from 505387-509793, Verified ORF [yeastflysequest.fasta]
  • Chd1p [Saccharomyces cerevisiae]gi|320737|pir||S30818 hypothetical protein YER164w - yeast (Saccharomyces cerevisiae)gi|603404|gb|AAB64691.1| Chd1p: transcriptional regulator [Saccharomyces cerevisiae]gi|418395|sp|P32657|CHD1_YEAST Chromo domain protei [nrdb_11152004_Chlamydomonas]
  • (P32657) Chromo domain protein 1 [cerv4932.FASTAC]
  • CHD1 SGDID:S000000966, Chr V from 505387-509793, Verified ORF, "Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SIL [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • CHD1 SGDID:S000000966, Chr V from 505387-509793, Verified ORF, "Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLI [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Chromo domain protein 1 (ATP-dependent helicase CHD1) [nr-271106-contam.fasta]
  • Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SILK complexes; Chd1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Chd1p: transcriptional regulator [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • CHD1 SGDID:S000000966, Chr V from 505387-509793, Verified ORF, "Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes" [yeast-bovrabprots.fasta]
  • CHD1 SGDID:S000000966, Chr V from 505387-509793, Verified ORF, "Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SILK complexes" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Chromo domain-containing protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CHD1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • CHD1 SGDID:S000000966, Chr V from 505392-509798, Genome Release 64-1-1, Verified ORF, "Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes" [yeast-030211-contam.fasta]
  • CHD1 SGDID:S000000966, Chr V from 505392-509798, Genome Release 64-2-1, Verified ORF, "Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes" [20141208_orf_trans.fasta]
  • YER164W SGDID:S000000966, Chr V from 505392-509798, Genome Release 64-1-1, Verified ORF, "Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1468 amino acids

    Gene Ontology:
    Cellular Component: transcription elongation factor complex [IPILink to PubMed article]
    SLIK (SAGA-like) complex [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    SAGA complex [IDALink to PubMed article]
    Biological Process: chromatin remodeling [IDALink to PubMed article]
    RNA elongation from RNA polymerase II promoter [IPILink to PubMed article]
    Molecular Function: ATPase activity [IDALink to PubMed article]
    RNA polymerase II transcription elongation factor activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAKDISTEV LQNPELYGLR RSHRAAAHQQ NYFNDSDDED DEDNIKQSRR KRMTTIEDDE  60
   61 DEFEDEEGEE DSGEDEDEED FEEDDDYYGS PIKQNRSKPK SRTKSKSKSK PKSQSEKQST 120
  121 VKIPTRFSNR QNKTVNYNID YSDDDLLESE DDYGSEEALS EENVHEASAN PQPEDFHGID 180
  181 IVINHRLKTS LEEGKVLEKT VPDLNNCKEN YEFLIKWTDE SHLHNTWETY ESIGQVRGLK 240
  241 RLDNYCKQFI IEDQQVRLDP YVTAEDIEIM DMERERRLDE FEEFHVPERI IDSQRASLED 300
  301 GTSQLQYLVK WRRLNYDEAT WENATDIVKL APEQVKHFQN RENSKILPQY SSNYTSQRPR 360
  361 FEKLSVQPPF IKGGELRDFQ LTGINWMAFL WSKGDNGILA DEMGLGKTVQ TVAFISWLIF 420
  421 ARRQNGPHII VVPLSTMPAW LDTFEKWAPD LNCICYMGNQ KSRDTIREYE FYTNPRAKGK 480
  481 KTMKFNVLLT TYEYILKDRA ELGSIKWQFM AVDEAHRLKN AESSLYESLN SFKVANRMLI 540
  541 TGTPLQNNIK ELAALVNFLM PGRFTIDQEI DFENQDEEQE EYIHDLHRRI QPFILRRLKK 600
  601 DVEKSLPSKT ERILRVELSD VQTEYYKNIL TKNYSALTAG AKGGHFSLLN IMNELKKASN 660
  661 HPYLFDNAEE RVLQKFGDGK MTRENVLRGL IMSSGKMVLL DQLLTRLKKD GHRVLIFSQM 720
  721 VRMLDILGDY LSIKGINFQR LDGTVPSAQR RISIDHFNSP DSNDFVFLLS TRAGGLGINL 780
  781 MTADTVVIFD SDWNPQADLQ AMARAHRIGQ KNHVMVYRLV SKDTVEEEVL ERARKKMILE 840
  841 YAIISLGVTD GNKYTKKNEP NAGELSAILK FGAGNMFTAT DNQKKLEDLN LDDVLNHAED 900
  901 HVTTPDLGES HLGGEEFLKQ FEVTDYKADI DWDDIIPEEE LKKLQDEEQK RKDEEYVKEQ 960
  961 LEMMNRRDNA LKKIKNSVNG DGTAANSDSD DDSTSRSSRR RARANDMDSI GESEVRALYK1020
 1021 AILKFGNLKE ILDELIADGT LPVKSFEKYG ETYDEMMEAA KDCVHEEEKN RKEILEKLEK1080
 1081 HATAYRAKLK SGEIKAENQP KDNPLTRLSL KKREKKAVLF NFKGVKSLNA ESLLSRVEDL1140
 1141 KYLKNLINSN YKDDPLKFSL GNNTPKPVQN WSSNWTKEED EKLLIGVFKY GYGSWTQIRD1200
 1201 DPFLGITDKI FLNEVHNPVA KKSASSSDTT PTPSKKGKGI TGSSKKVPGA IHLGRRVDYL1260
 1261 LSFLRGGLNT KSPSADIGSK KLPTGPSKKR QRKPANHSKS MTPEITSSEP ANGPPSKRMK1320
 1321 ALPKGPAALI NNTRLSPNSP TPPLKSKVSR DNGTRQSSNP SSGSAHEKEY DSMDEEDCRH1380
 1381 TMSAIRTSLK RLRRGGKSLD RKEWAKILKT ELTTIGNHIE SQKGSSRKAS PEKYRKHLWS1440
 1441 YSANFWPADV KSTKLMAMYD KITESQKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CHD1 CKA1 CKA2 CKB1 CKB2 PAF1 POB3 RTF1 SPT16 UTP22
    View Details Krogan NJ, et al. (2006) CAB3 CHD1 CKA1 CKA2 CKB1 CKB2 ELF1 HOT1 MSC3 NRG1 PGA2 REH1 RIM13 VHS3 YLR407W
    View Details Gavin AC, et al. (2006) CHD1 SSA4
    View Details Gavin AC, et al. (2002) CAB3 CHD1 CKA1 CKA2 CKB1 CKB2 HHF1, HHF2 HOT1 ISW1 ISW2 NIP1 PRT1 RET1 RPG1 RVB2 SPT16 SSA4 TIF35 UTP22 VPS1 YTA7
    View Details Ho Y, et al. (2002) CHD1 HSH49 MLC2 RSE1
    View Details Qiu et al. (2008) ADA2 ARP4 CDC73 CHD1 ELC1 ELP2 ELP6 GCN5 HFI1 IKI1 IKI3 LEO1 NGG1 PAF1 SGF73 SPN1 SPT16 SPT5 SPT6 SPT8 SUS1 TAF12 TAF14 TAF5 TAF6 TAF9 TFB5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CHD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..133] deduced N/A No confident structure predictions are available.
    2 View Details [134..261] Pfam 17.065502 'chromo' (CHRromatin Organisation MOdifier) domain No confident structure predictions are available.
    3 View Details [262..341] ORFEUS 13.61 RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
    4 View Details [342..560] ORFEUS 13.61 RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
    5 View Details [561..626] ORFEUS 12.85 Putative DEAD box RNA helicase
    6 View Details [627..694] PSI-BLAST 7.221849 Putative DEAD box RNA helicase
    7 View Details [695..927] PSI-BLAST 7.30103 Nucleotide excision repair enzyme UvrB
    8 View Details [928..1105] MSA 1.175981 View MSA. Confident ab initio structure predictions are available.
    9 View Details [1106..1266] MSA 3.051976 View MSA. No confident structure predictions are available.
    10 View Details [1267..1361] deduced N/A No confident structure predictions are available.
    11 View Details [1362..1468] MSA 1.009974 View MSA. Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription elongation regulator activity
    		•  4.88034936399943 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  3.7424679735172 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  3.7424679735172 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  2.48980517248425 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  2.27909822963553 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • acetyltransferase activity
    		•  1.95584629179223 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.23094623498843 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • motor activity
    		•  1.14667913749579 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.07968294254548 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription activator activity
    		•  0.889929694023098 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.862685397469217 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.75415390146713 bayes_pls_golite062009
  • helicase activity
    		•  0.6191010101321 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.60036517876321 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.543891899378373 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.500462538667228 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.41398614759796 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.243902356228423 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.18426050934025 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.147579541298736 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.14606996093053 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.133017653323467 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.13050483816765 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.113504049290503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.111293884322157 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.089234257580272 bayes_pls_golite062009
  • actin binding
    		•  0.00482938540552702 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle