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Protein Overview: GRS1

General Information:
Name(s) found: GRS1 / YBR121C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 667 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IMPLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    Biological Process: glycyl-tRNA aminoacylation [IMPLink to PubMed article][ISSLink to PubMed article]
    transcription termination [IMPLink to PubMed article]
    Molecular Function: glycine-tRNA ligase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVEDIKKAR AAVPFNREQL ESVLRGRFFY APAFDLYGGV SGLYDYGPPG CAFQNNIIDA  60
   61 WRKHFILEED MLEVDCTMLT PYEVLKTSGH VDKFSDWMCR DLKTGEIFRA DHLVEEVLEA 120
  121 RLKGDQEARG LVEDANAAAK DDAEKKKRKK KVKQIKAVKL DDDVVKEYEE ILAKIDGYSG 180
  181 PELGELMEKY DIGNPVTGET LESPRAFNLM FETAIGPSGQ LKGYLRPETA QGQFLNFNKL 240
  241 LEFNNSKTPF ASASIGKSFR NEISPRAGLL RVREFLMAEI EHFVDPLDKS HPKFNEIKDI 300
  301 KLSFLPRDVQ EAGSTEPIVK TVGEAVASRM VDNETLGYFI ARIYQFLMKI GVDESKLRFR 360
  361 QHMANEMAHY AADCWDGELK TSYGWIECVG CADRSAYDLT VHSKKTKEKL VVRQKLDNPI 420
  421 EVTKWEIDLT KKLFGPKFRK DAPKVESHLL NMSQDDLASK AELLKANGKF TIKVDGVDGE 480
  481 VELDDKLVKI EQRTKVEHVR EYVPSVIEPS FGIGRIIYSV FEHSFWNRPE DNARSVLSFP 540
  541 PLVAPTKVLL VPLSNHKDLV PVHHEVAKIL RKSQIPFKID DSGVSIGKRY ARNDELGTPF 600
  601 GVTIDFESAK DHSVTLRERD STKQVRGSVE NVIKAIRDIT YNGASWEEGT KDLTPFIAQA 660
  661 EAEAETD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Hazbun TR, et al. (2003) GRS1 KAR2 TUB3 YNL313C
    View Details Ho Y, et al. (2002) AAT2 ACS2 ADE3 ADE6 ADH4 ADO1 AIM46 ALA1 APE2 ARA1 ARE1 ARG4 BAT1 CAR2 CDC10 CDC33 CDC60 CLU1 CPR1 CYS3 DED81 DPS1 ENP1 ERG10 ERG20 FET4 FUN12 GCY1 GPH1 GRS1 HAS1 HOM2 HYP2 ILS1 IMD2 IMD3 IMD4 KRE33 KRI1 KRS1 LSP1 MAG2 MDH3 MGM101 MPC54 MSC3 NAS6 NOC2 NOP12 NOP4 NPL3 OLA1 OYE2 PAB1 PDC5 PDC6 PFK2 PGM2 PMI40 PRP6 RPF2 RRP12 SAC6 SCP160 SOD1 SSZ1 SUI1 THR4 TIF4631 TIF4632 TPS1 TRR1 UBA1 UTP22 YDL124W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run YNL313C No Comments Hazbun TR, et al. (2003)
    View Run YNL313C No Comments Hazbun TR, et al. (2003)
    View Run GWT1 No Comments Hazbun TR, et al. (2003)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GRS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..460] PSI-BLAST 437.457575 Glycyl-tRNA synthetase (GlyRS), C-terminal domain; Glycyl-tRNA synthetase (GlyRS)
    2 View Details [461..591] PSI-BLAST 437.457575 Glycyl-tRNA synthetase (GlyRS), C-terminal domain; Glycyl-tRNA synthetase (GlyRS)
    3 View Details [592..667] PSI-BLAST 51.045757 Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle