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View Structure Prediction Details

Protein: GRS1
Organism: Saccharomyces cerevisiae
Length: 667 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GRS1.

Description E-value Query
Range
Subject
Range
GRS1 - Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bea...
0.0 [1..667] [1..667]
gi|30725863, gi|... - gi|30725863|ref|NP_851009.1| glycyl-tRNA synthetase [Mus musculus], gi|18256043|gb|AAH21747.1| Glycy...
0.0 [1..666] [95..726]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..666] [105..736]
gi|6996010, gi|5... - gi|6996010|ref|NP_002038.1| glycyl-tRNA synthetase [Homo sapiens], gi|600727|gb|AAA57001.1| glycyl-t...
0.0 [1..666] [51..682]
Aats-gly-PA - The gene Glycyl-tRNA synthetase is referred to in FlyBase by the symbol Dmel\Aats-gly (CG6778, FBgn0...
gi|220945008, gi... - gi|220954840|gb|ACL89963.1| Aats-gly-PA [synthetic construct], gi|220945008|gb|ACL85047.1| Aats-gly-...
0.0 [1..663] [51..679]
SYG_BOMMO - Glycine--tRNA ligase OS=Bombyx mori PE=1 SV=2
0.0 [1..663] [51..676]
SYG_SCHPO - Putative glycine--tRNA ligase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=grs1 PE=3 SV...
SPAC3F10.03 - glycine tRNA-ligase
0.0 [11..661] [6..652]

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Predicted Domain #1
Region A:
Residues: [1-460]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVEDIKKAR AAVPFNREQL ESVLRGRFFY APAFDLYGGV SGLYDYGPPG CAFQNNIIDA  60
   61 WRKHFILEED MLEVDCTMLT PYEVLKTSGH VDKFSDWMCR DLKTGEIFRA DHLVEEVLEA 120
  121 RLKGDQEARG LVEDANAAAK DDAEKKKRKK KVKQIKAVKL DDDVVKEYEE ILAKIDGYSG 180
  181 PELGELMEKY DIGNPVTGET LESPRAFNLM FETAIGPSGQ LKGYLRPETA QGQFLNFNKL 240
  241 LEFNNSKTPF ASASIGKSFR NEISPRAGLL RVREFLMAEI EHFVDPLDKS HPKFNEIKDI 300
  301 KLSFLPRDVQ EAGSTEPIVK TVGEAVASRM VDNETLGYFI ARIYQFLMKI GVDESKLRFR 360
  361 QHMANEMAHY AADCWDGELK TSYGWIECVG CADRSAYDLT VHSKKTKEKL VVRQKLDNPI 420
  421 EVTKWEIDLT KKLFGPKFRK DAPKVESHLL NMSQDDLASK 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 437.457575
Match: 1atiA_
Description: Glycyl-tRNA synthetase (GlyRS), C-terminal domain; Glycyl-tRNA synthetase (GlyRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [461-591]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AELLKANGKF TIKVDGVDGE VELDDKLVKI EQRTKVEHVR EYVPSVIEPS FGIGRIIYSV  60
   61 FEHSFWNRPE DNARSVLSFP PLVAPTKVLL VPLSNHKDLV PVHHEVAKIL RKSQIPFKID 120
  121 DSGVSIGKRY A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 437.457575
Match: 1atiA_
Description: Glycyl-tRNA synthetase (GlyRS), C-terminal domain; Glycyl-tRNA synthetase (GlyRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [592-667]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNDELGTPFG VTIDFESAKD HSVTLRERDS TKQVRGSVEN VIKAIRDITY NGASWEEGTK  60
   61 DLTPFIAQAE AEAETD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.045757
Match: 1qf6A_
Description: Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle