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Protein Overview: PSK1

General Information:
Name(s) found: PSK1 / YAL017W [SGD]
Description(s) found:
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  • gi|6319302|ref|NP_009385.1| One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; Psk1p [NCBI NR]
  • gi|400097|sp|P31374.1|KAB7_YEAST RecName: Full=Probable serine/threonine-protein kinase YAL017W [NCBI NR]
  • gi|171858|gb|AAC04940.1| Fun31p: Putative serine/threonine kinase [Saccharomyces cerevisiae] [NCBI NR]
  • Probable serine/threonine-protein kinase YAL017W OS=Saccharomyces cerevisiae GN=YAL017W PE=1 SV=1 [Swiss-Prot]
  • PSK1 PAS kinase involved in the control of sugar metabolism and translation [mips]
  • One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status [SGD]
  • FUN31, Chr I from 120224-124294 [yeast_orfs2]
  • Chr I from 120224-124294 [yeastorf3.fasta]
  • Chr I from 120227-124297 [yeastorf4.fasta]
  • (P31374) Probable serine/threonine-protein kinase YAL017W (EC 2.7.1.-) [4932.FASTACCERV.txt]
  • PSK1 SGDID:S0000015, Chr I from 120228-124298, Verified ORF [yeastflysequest.fasta]
  • PSK1 SGDID:S0000015, Chr I from 120226-124296, Verified ORF [10112005cervSGD.fasta]
  • Fun31p: Putative serine/threonine kinase [Saccharomyces cerevisiae]gi|6319302|ref|NP_009385.1| One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in respo [nrdb_11152004_Chlamydomonas]
  • (P31374) Probable serine/threonine-protein kinase YAL017W (EC 2.7.1.37) [cerv4932.FASTAC]
  • PSK1 SGDID:S000000015, Chr I from 120226-124296, Verified ORF, "One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Probable serine/threonine-protein kinase YAL017W [nr-271106-contam.fasta]
  • One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; Psk1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Fun31p: Putative serine/threonine kinase [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PSK1 SGDID:S000000015, Chr I from 120226-124296, Verified ORF, "One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1356 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: hexose metabolic process [IGILink to PubMed article][IMPLink to PubMed article]
    protein amino acid phosphorylation [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: protein serine/threonine kinase activity [IMPLink to PubMed article][ISSLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPYIGASNLS EHSFVNLKEK HAITHKGTSS SVASLQTPPS PDQENHIDNE LENYDTSLSD  60
   61 VSTPNKKEGD EFQQSLRDTF ASFRKTKPPP PLDFEQPRLP STASSSVDST VSSPLTDEDI 120
  121 KELEFLPNES THSYSYNPLS PNSLAVRLRI LKRSLEIIIQ NPSMLLEPTP DDLPPLKEFA 180
  181 GRRSSLPRTS ASANHLMNRN KSQIWNTTSA TLNAFVNNTS SSSAASSALS NKKPGTPVFP 240
  241 NLDPTHSQTF HRANSLAYLP SILPEQDPLL KHNNSLFRGD YGNNISPERP SFRQPFKDQT 300
  301 SNLRNSSLLN ERAYQEDETF LPHHGPSMDL LNEQRANLKS LLNLLNETLE KNTSERASDL 360
  361 HMISLFNLNK LMLGDPKKNN SERDKRTEKL KKILLDSLAE PFFEHYNFIG DNPIADTDEL 420
  421 KEEIDEFTGS GDTTAITDIR PQQDYGRILR TFTSTKNSAP QAIFTCSQED PWQFRAANDL 480
  481 ACLVFGISQN AIRALTLMDL IHTDSRNFVL HKLLSTEGQE MVFTGEIIGI VQPETLSSSK 540
  541 VVWASFWAKR KNGLLVCVFE KVPCDYVDVL LNLDDFGAEN IVDKCELLSD GPTLSSSSTL 600
  601 SLPKMASSPT GSKLEYSLER KILEKSYTKP TSTENRNGDE NQLDGDSHSE PSLSSSPVRS 660
  661 KKSVKFANDI KDVKSISQSL AKLMDDVRNG VVFDPDDDLL PMPIKVCNHI NETRYFTLNH 720
  721 LSYNIPCAVS STVLEDELKL KIHSLPYQAG LFIVDSHTLD IVSSNKSILK NMFGYHFAEL 780
  781 VGKSITEIIP SFPKFLQFIN DKYPALDITL HKNKGLVLTE HFFRKIQAEI MGDRKSFYTS 840
  841 VGIDGLHRDG CEIKIDFQLR VMNSKVILLW VTHSRDVVFE EYNTNPSQLK MLKESELSLM 900
  901 SSASSSASSS KKSSSRISTG TLKDMSNLST YEDLAHRTNK LKYEIGDDSR AHSQSTLSEQ 960
  961 EQVPLENDKD SGEMMLADPE MKHKLELARI YSRDKSQFVK EGNFKVDENL IISKISLSPS1020
 1021 TESLADSKSS GKGLSPLEEE KLIDENATEN GLAGSPKDED GIIMTNKRGN QPVSTFLRTP1080
 1081 EKNIGAQKHV KKFSDFVSLQ KMGEGAYGKV NLCIHKKNRY IVVIKMIFKE RILVDTWVRD1140
 1141 RKLGTIPSEI QIMATLNKKP HENILRLLDF FEDDDYYYIE TPVHGETGCI DLFDLIEFKT1200
 1201 NMTEFEAKLI FKQVVAGIKH LHDQGIVHRD IKDENVIVDS KGFVKIIDFG SAAYVKSGPF1260
 1261 DVFVGTIDYA APEVLGGNPY EGQPQDIWAI GILLYTVVFK ENPFYNIDEI LEGDLKFNNA1320
 1321 EEVSEDCIEL IKSILNRCVP KRPTIDDINN DKWLVI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PSK1 PSK2
    View Details Krogan NJ, et al. (2006) GET1 GET2 GET3 PSK1 TAT1 YHP1
    View Details Gavin AC, et al. (2006) HEM13 PSK1 TAF7 VAS1
    View Details Gavin AC, et al. (2002) ADA2 ADH1 BMH1 BMH2 CLU1 FUN19 GCN5 HEM13 HFI1 KAP114 KAP123 MED4 MES1 MNN4 MOT1 MYO1 MYO4 NGG1 NOP1 NTH1 NTH2 PFK2 PIK1 PSK1 PTC1 PUF6 RPB2 RPN9 RPO21 RPT5 RTG2 RVB2 SGF29 SGF73 SIN3 SIN4 SPT15 SPT20 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TEF4 UBP8 VAS1 VPS1
    View Details Ho Y, et al. (2002) FUN30 GPH1 PSK1 PSK2 RVB1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PSK1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..590] ORFEUS 7.46 Haloperoxidase (bromoperoxidase)
    2 View Details [591..912] deduced N/A No confident structure predictions are available.
    3 View Details [913..1054] PSI-BLAST 12.045757 C2 domain from protein kinase c (alpha)
    4 View Details [1055..1151]
    [1167..1186]    		 PSI-BLAST 319.9897 cAMP-dependent PK, catalytic subunit
    5 View Details [1152..1166]
    [1187..1356]    		 PSI-BLAST 319.9897 cAMP-dependent PK, catalytic subunit
    6 View Details [906..1091] PSI-BLAST 12.69897 C2 domain from protein kinase c (alpha)
    7 View Details [1092..1356] PSI-BLAST 111.0 No description for 2fh9A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • transcription regulator activity
    		•  4.27604928641749 bayes_pls_golite062009
  • DNA binding
    		•  3.83861939247274 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.43738039086015 bayes_pls_golite062009
  • transcription factor activity
    		•  3.18442852449976 bayes_pls_golite062009
  • binding
    		•  3.0194696248926 bayes_pls_golite062009
  • transcription factor binding
    		•  2.22314179303094 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.13819142609078 bayes_pls_golite062009
  • transcription activator activity
    		•  1.8593473738006 bayes_pls_golite062009
  • protein kinase activity
    		•  1.64278494326255 bayes_pls_golite062009
  • protein binding
    		•  1.60673447924806 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.54935001412565 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.34369087457971 bayes_pls_golite062009
  • kinase activity
    		•  1.27787411134399 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.26593567694405 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.06445298547053 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.934727986222767 bayes_pls_golite062009
  • enzyme binding
    		•  0.902069383016175 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.865848090169615 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.614755150740891 bayes_pls_golite062009
  • histone acetyltransferase binding
    		•  0.609670492126344 bayes_pls_golite062009
  • transferase activity
    		•  0.534003294436004 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.3832620238984 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.184733508317397 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.119454387636252 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.104316215089923 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.0413435093582974 bayes_pls_golite062009
    6
    Term Confidence Notes
  • binding
    		•  2.77482286467294 bayes_pls_golite062009
  • lipid binding
    		•  1.47484095830847 bayes_pls_golite062009
  • protein binding
    		•  1.33917246836907 bayes_pls_golite062009
  • phospholipid binding
    		•  0.98776359922762 bayes_pls_golite062009
  • calcium-dependent phospholipid binding
    		•  0.368277796845269 bayes_pls_golite062009
  • profilin binding
    		•  0.32399339703241 bayes_pls_golite062009
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle