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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Yku80. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 32 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ATP3
  • mitochondrial proton-transporting ATP synthase, central stalk
  • mitochondrion
  • ATP synthesis coupled proton transport
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
  • AVO1
  • TORC2 complex
  • cytoplasm
  • fungal-type cell wall organization
  • negative regulation of Ras protein signal transduction
  • regulation of cell growth
  • establishment or maintenance of actin cytoskeleton polarity
  • Ras GTPase binding
  • CCT5
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • CLU1
  • cytoplasm
  • eukaryotic translation initiation factor 3 complex
  • translational initiation
  • mitochondrion organization
  • molecular_function
  • DHH1
  • cytoplasm
  • cytoplasmic mRNA processing body
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • protein binding
  • RNA helicase activity
  • DPB2
  • replication fork
  • nucleus
  • cytoplasm
  • epsilon DNA polymerase complex
  • lagging strand elongation
  • leading strand elongation
  • nucleotide-excision repair
  • mismatch repair
  • DNA binding
  • nucleotidyltransferase activity
  • DNA-directed DNA polymerase activity
  • double-stranded DNA binding
  • transferase activity
  • FUN12
  • mitochondrion
  • translational initiation
  • translation initiation factor activity
  • GTPase activity
  • GAL7
  • cytoplasm
  • galactose catabolic process
  • UTP:galactose-1-phosphate uridylyltransferase activity
  • GPH1
  • cytoplasm
  • glycogen catabolic process
  • glycogen phosphorylase activity
  • IDH1
  • mitochondrial matrix
  • mitochondrion
  • mitochondrial nucleoid
  • glutamate biosynthetic process
  • isocitrate metabolic process
  • tricarboxylic acid cycle
  • isocitrate dehydrogenase (NAD+) activity
  • ILV2
  • mitochondrion
  • acetolactate synthase complex
  • branched chain family amino acid biosynthetic process
  • acetolactate synthase activity
  • FAD binding
  • MET16
  • cytoplasm
  • intracellular
  • response to drug
  • sulfate assimilation
  • methionine metabolic process
  • phosphoadenylyl-sulfate reductase (thioredoxin) activity
  • MKK2
  • intracellular
  • signal transduction
  • protein amino acid phosphorylation
  • MAP kinase kinase activity
  • NOG2
  • nucleus
  • nucleolus
  • nucleoplasm
  • ribosomal large subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • GTPase activity
  • NPA3
  • cytoplasm
  • biological_process
  • ATPase activity
  • PDX1
  • mitochondrial pyruvate dehydrogenase complex
  • mitochondrion
  • acetyl-CoA biosynthetic process from pyruvate
  • protein binding
  • PHO85
  • nucleus
  • glycogen metabolic process
  • response to drug
  • telomere maintenance
  • protein amino acid phosphorylation
  • phosphate metabolic process
  • cell cycle
  • cyclin-dependent protein kinase activity
  • PUF3
  • cytoplasm
  • external side of mitochondrial outer membrane
  • mRNA catabolic process
  • aerobic respiration
  • mitochondrion localization
  • mitochondrion organization
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPN12
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • SIS1
  • nucleus
  • cytoplasm
  • cytosolic small ribosomal subunit
  • translational initiation
  • protein folding
  • unfolded protein binding
  • chaperone regulator activity
  • SLX1
  • nucleus
  • DNA-dependent DNA replication
  • response to DNA damage stimulus
  • 5'-flap endonuclease activity
  • SRP54
  • signal recognition particle, endoplasmic reticulum targeting
  • SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
  • protein targeting to ER
  • signal sequence binding
  • STI1
  • cytoplasm
  • protein folding
  • chaperone inhibitor activity
  • chaperone activator activity
  • Hsp90 protein binding
  • Hsp70 protein binding
  • TEM1
  • spindle pole body
  • regulation of exit from mitosis
  • protein binding
  • GTPase activity
  • TFC7
  • transcription factor TFIIIC complex
  • transcription initiation from RNA polymerase III promoter
  • RNA polymerase III transcription factor activity
  • VMA8
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
  • vacuolar acidification
  • proton-transporting ATPase activity, rotational mechanism
  • YER077C
  • mitochondrion
  • biological_process
  • molecular_function
  • YGR266W
  • mitochondrion
  • mitochondrial outer membrane
  • plasma membrane
  • biological_process
  • molecular_function
  • YKR051W
  • cellular_component
  • biological_process
  • molecular_function
  • YKU80
  • nuclear chromatin
  • nuclear telomeric heterochromatin
  • double-strand break repair via homologous recombination
  • telomere maintenance
  • chromatin assembly or disassembly
  • chromatin silencing
  • double-strand break repair via nonhomologous end joining
  • donor selection
  • DNA binding
  • RNA binding
  • damaged DNA binding
  • YLR271W
  • nucleus
  • cytoplasm
  • biological_process
  • molecular_function
  • YPR003C
  • endoplasmic reticulum
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proton-transporting two-sector ATPase complex, catalytic domain 1.8876E-3 32 13 2 6292
    intracellular 5.0801E-3 32 4975 31 6292
    external side of mitochondrial outer membrane 5.0858E-3 32 1 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translational initiation 1.1991E-3 32 42 3 6292
    generation of precursor metabolites and energy 2.7664E-3 32 195 5 6292
    acetyl-CoA metabolic process 4.497E-3 32 20 2 6292
    energy derivation by oxidation of organic compounds 6.4846E-3 32 149 4 6292
    protein folding 7.0201E-3 32 78 3 6292
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 8.1255E-3 32 27 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    GTPase activity 3.521E-3 32 61 3 6292
    glycogen phosphorylase activity 5.0858E-3 32 1 1 6292
    UTP:galactose-1-phosphate uridylyltransferase activity 5.0858E-3 32 1 1 6292
    phosphorylase activity 5.0858E-3 32 1 1 6292
    chaperone inhibitor activity 5.0858E-3 32 1 1 6292
    phosphoadenylyl-sulfate reductase (thioredoxin) activity 5.0858E-3 32 1 1 6292
    nucleoside-triphosphatase activity 5.5719E-3 32 329 6 6292
    binding 7.5795E-3 32 1294 13 6292
    pyrophosphatase activity 7.8194E-3 32 353 6 6292
    hydrolase activity, acting on acid anhydrides 7.8194E-3 32 353 6 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 7.8194E-3 32 353 6 6292

    YRC Informatics Platform - Version 3.0
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