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Protein Overview: ABF2

General Information:
Name(s) found: ABF2 / YMR072W [SGD]
Description(s) found:
Found 32 descriptions.
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  • Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 183 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial chromosome [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    mitochondrial nucleoid [IDALink to PubMed article]
    Biological Process: mitochondrion inheritance [IMPLink to PubMed article]
    mitochondrial genome maintenance [IMPLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    DNA bending activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSYSLLTRS FHESSKPLFN LASTLLKASK RTQLRNELIK QGPKRPTSAY FLYLQDHRSQ  60
   61 FVKENPTLRP AEISKIAGEK WQNLEADIKE KYISERKKLY SEYQKAKKEF DEKLPPKKPA 120
  121 GPFIKYANEV RSQVFAQHPD KSQLDLMKII GDKWQSLDQS IKDKYIQEYK KAIQEYNARY 180
  181 PLN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ABF2 ASE1 HTA2 HTZ1 NHP6A NOP53 RPL11B RPL17A RPL17B RPL20A RPL2A, RPL2B RPL36A RPL4A RPS14A RPS17B RPS30B, RPS30A RPS5 RSC8
    View Details Krogan NJ, et al. (2006) ABF2 ARG82 CKI1 CMR1 HHF1, HHF2 HTA1 HTA2 HTB1 HTB2 NUP188 PPH3 PSY2 PSY4 RRD1 SLX5 SLX8 SPT5 STP1 TOP2
    View Details Gavin AC, et al. (2006) ABF2 VPS1
    View Details Gavin AC, et al. (2002) ABF2 CKA1 CKA2 CKB1 CKB2 CTI6 DEP1 DOT6 EAF3 ECM16 HTA2 IOC3 ISW1 MED4 NHP10 NRD1 PHO23 RCO1 RPD3 RSC8 RXT2 RXT3 SAP30 SDS3 SIN3 STO1 TOP1 TUP1 UME1 UME6 VPS1
    View Details Qiu et al. (2008) ABF2 MGM101 RIM1 YHM2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC7 ABF2 1 Unpublished Fields Lab Data
    View Screen CDC48 ABF2 1 Unpublished Fields Lab Data
    View Screen CDC4 ABF2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ABF2 Huh WK, et al. (2003)
    View Data ABF2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..113] PSI-BLAST 68.36704 HMG1, domains A and B
    2 View Details [114..183] ORFEUS 14.9 SRY

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.04393542109417 bayes_pls_golite062009
  • DNA binding
    		•  1.88326659692279 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.85157640081091 bayes_pls_golite062009
  • chromatin binding
    		•  1.82810083714605 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.34639198670075 bayes_pls_golite062009
  • protein binding
    		•  1.33904668423876 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.08208740778246 bayes_pls_golite062009
  • transcription factor activity
    		•  0.585772620695985 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.45921402500371 bayes_pls_golite062009
  • transcription factor binding
    		•  0.19768703289845 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.16971196361447 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle