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Protein Overview: NAB6

General Information:
Name(s) found: NAB6 / YML117W [SGD]
Description(s) found:
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  • gi|798883|emb|CAA89101.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6323518|ref|NP_013589.1| Putative RNA-binding protein, based on computational analysis of large-scale protein-protein interaction data; Nab6p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|2497065|sp|Q03735.1|NAB6_YEAST RecName: Full=RNA-binding protein NAB6; AltName: Full=Nucleic acid-binding protein 6 [NCBI NR]
  • pir||S53955 hypothetical protein YML117w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Uncharacterized RNA-binding protein YML117W OS=Saccharomyces cerevisiae GN=YML117W PE=1 SV=1 [Swiss-Prot]
  • RNA-binding protein NAB6 OS=Saccharomyces cerevisiae GN=NAB6 PE=1 SV=1 [Swiss-Prot]
  • NAB6 Protein of unknown function [mips]
  • Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP [SGD]
  • YML117W, Chr XIII from 34243-37647 [yeast_orfs2]
  • Chr XIII from 34243-37647 [yeastorf3.fasta]
  • (Q03735) Hypothetical 126.1 kDa protein in NDI1-ATR1 intergenic region [4932.FASTACCERV.txt]
  • NAB6 SGDID:S0004585, Chr XIII from 34243-37647, Uncharacterized ORF [yeastflysequest.fasta]
  • Nab6p [Saccharomyces cerevisiae]gi|798883|emb|CAA89101.1| unknown [Saccharomyces cerevisiae]gi|2497065|sp|Q03735|YML7_YEAST Hypothetical 126.1 kDa protein in NDI1-ATR1 intergenic regiongi|1077939|pir||S53955 hypothetical protein YML117w - yeast (Saccha [nrdb_11152004_Chlamydomonas]
  • NAB6 SGDID:S000004585, Chr XIII from 34243-37647, Uncharacterized ORF, "Putative RNA-binding protein, based on computational analysis of large-scale protein-protein interaction data" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • NAB6 SGDID:S000004585, Chr XIII from 34243-37647, Verified ORF, "Putative RNA-binding protein, based on computational analysis of large-scale protein-protein interaction data" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • NAB6 SGDID:S000004585, Chr XIII from 34243-37647, Verified ORF, "Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting ag [SGD_S-cerevisiae_na_05-08-2009_con_reversed.fasta]
  • Putative RNA-binding protein, based on computational analysis of large-scale protein-protein interaction data; Nab6p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Probable RNA-binding protein YML117W [nr-271106-contam.fasta]
  • unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • NAB6 SGDID:S000004585, Chr XIII from 34243-37647, Verified ORF, "Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP" [scerevisihumanrev.fasta]
  • [chemostatdb.fasta]
  • RNA-binding protein NAB6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NAB6 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • NAB6 SGDID:S000004585, Chr XIII from 34243-37647, Genome Release 64-1-1, Verified ORF, "Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP" [yeast-030211-contam.fasta]
  • NAB6 SGDID:S000004585, Chr XIII from 34243-37647, Genome Release 64-2-1, Verified ORF, "Putative RNA-binding protein; associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP" [20141208_orf_trans.fasta]
  • YML117W SGDID:S000004585, Chr XIII from 34243-37647, Genome Release 64-1-1, Verified ORF, "Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1134 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: RNA metabolic process [RCALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNSNSKKPV ANYAYRQQQD YNGMNAMVGN PMMYHPVDFV NGAGQYGPSQ HPAYYTNSPL  60
   61 PNIPPTPFDT AYGASLFPSH LLMGSPFVSS PNMQSGYNSA RSSNLKRKAY SRPVSNHNGY 120
  121 NGNSNSNQNN TNNGMVTPSN YYRMGRNSFS RNNNSTRNVT HNNNKGCDTR NNSGRRTFAR 180
  181 NNIFDDILPE MLLQRPFCIN YKVLPTGDDA YRTRSLLIEN VDHSIDLHSI VKNFVKSNTL 240
  241 ESAYLIEGGK SDDSKDVETK NLSILISFLT KGDCLNFYNN ILQRLSEFKT FLKSEALNLK 300
  301 FVCLNYDPKC LPTFIESEAL TENAEEADIT NGSTMISASL HHNIANKDAT RSIIIEFKSP 360
  361 VEKSDLFKKK LQFLDRSKNK RYILESIDLV NTDVPSNQFP ENYAVLTFLN ISMAIEVLDY 420
  421 LKKYSKNLGI SKCFYVSLAP LVVSSARSSV ANIYEGKTST HRLSVPSVTA GNNNDSNNNG 480
  481 NNNKSNMSGI TTLNNNSSIG VSVYGHSNMS LTSLSSSVSL NEEIDMLATK LQGVELDGTY 540
  541 LEINYRDYQT PTIEEHSTHL SNVKISKTTE NSRQFSQDIP SPLPLNEHMF MNDSNQSNGA 600
  601 IIPQQLIATP SPVSPNLQMN QRVLPNPITQ SLEQNFNVSA KVASSMGSDI GNRTIYIGNI 660
  661 NPRSKAEDIC NVVRGGILQS IKYIPEKKIC FVTFIEAPSA VQFYANSFID PIVLHGNMLR 720
  721 VGWGHYSGPL PKLISLAVTI GASRNVYVSL PEFAFKEKFI HDPQYKKLHE TLSLPDAEQL 780
  781 REDFSTYGDI EQINYLSDSH CCWINFMNIS SAISLVEEMN KESTVQNESG EVTLKRATEE 840
  841 KFGGRYKGLL INYGKDRCGN INKNLIAGKN SRFYKKVKRP SYNIRLSKLE EKRRQNEIDE 900
  901 KEKAFDKPLN LESLGISLDA HKDNGGGETG TANNTGHENE SELEAENENG NETGSFGGLG 960
  961 LAVASSDVKR ATSDETDYED IFNKSSGSSD SSSDVEVIMH SPSDPEYALK SQTLRSSSQT1020
 1021 VINSKRPVKI EDEEEAVGMS QLNYRSSLRQ APPRAPSTLS YNHSKNNETP MQDIFTNGET1080
 1081 ANNRKKKRGS FARHRTIPGS DVMAQYLAQV QHSTFMYAAN ILGASAEDNT HPDE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) NAB3 NAB6 NRD1 TIF4632
    View Details Gavin AC, et al. (2006) NAB6 NRP1 PAB1
    View Details Gavin AC, et al. (2002) AIR2 ASC1 BRR1 BUR2 CBC2 CBF5 CDC33 CLU1 CRN1 DBP2 ECM29 HCA4 HEK2 HHF1, HHF2 HTA1 IML1 KAP123 KAP95 LHP1 LUC7 MEC1 MIP6 MIS1 MRP7 MRPL23 MSH4 MUD1 NAB3 NAB6 NAM7 NAM8 NPL3 NRD1 NRP1 NUP60 POL2 PRP39 PRP40 PRP42 PUB1 PUS7 RBG1 ROM2 RPA135 RSE1 SBP1 SCP160 SEN1 SEN54 SGN1 SGV1 SMD1 SMD2 SMD3 SNF2 SNP1 SNU56 SNU71 SRO9 SRP1 STM1 STO1 SUI3 SUP35 SUP45 SWI1 TAO3 THO2 TIF1, TIF2 TIF4631 TIF4632 USO1 UTP20 VAC14 VPS5 YJL017W YMR310C YRA2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CAB4 No Comments Hazbun TR, et al. (2003)
    View Run ASF1 3908: TAP-tagged, includes hir2(delta) in background Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NAB6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..118]
    [136..161]
    [442..501]    		 ORFEUS 7.82 Adenovirus hexon
    2 View Details [119..135]
    [162..287]
    [325..350]    		 ORFEUS 7.82 Adenovirus hexon
    3 View Details [288..324]
    [351..441]
    [502..552]    		 ORFEUS 7.82 Adenovirus hexon
    4 View Details [553..636] ORFEUS 7.97 Baseplate structural protein gp27
    5 View Details [637..726] PSI-BLAST 36.0 Hu antigen D (Hud)
    6 View Details [727..846] PSI-BLAST 36.0 Hu antigen D (Hud)
    7 View Details [847..909] deduced N/A No confident structure predictions are available.
    8 View Details [910..1077] MSA 1.121988 View MSA. No confident structure predictions are available.
    9 View Details [1078..1134] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.46194714498106 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.889591023319018 bayes_pls_golite062009
  • RNA binding
    		•  0.535898980134848 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle