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Protein Overview: LPD1

General Information:
Name(s) found: LPD1 / YFL018C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 499 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial pyruvate dehydrogenase complex [TAS]
    mitochondrial oxoglutarate dehydrogenase complex [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    glycine cleavage complex [TASLink to PubMed article]
    mitochondrial nucleoid [IDALink to PubMed articleLink to PubMed article]
    Biological Process: acetyl-CoA biosynthetic process from pyruvate [TAS]
    leucine catabolic process [IMPLink to PubMed article]
    valine catabolic process [IMPLink to PubMed article]
    L-serine biosynthetic process [IMPLink to PubMed article]
    isoleucine catabolic process [IMPLink to PubMed article]
    glycine catabolic process [IMPLink to PubMed article]
    Molecular Function: oxoglutarate dehydrogenase (succinyl-transferring) activity [ICLink to PubMed article]
    pyruvate dehydrogenase (acetyl-transferring) activity [IC]
    glycine dehydrogenase (decarboxylating) activity [TASLink to PubMed article]
    dihydrolipoyl dehydrogenase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRIRSLLNN KRAFSSTVRT LTINKSHDVV IIGGGPAGYV AAIKAAQLGF NTACVEKRGK  60
   61 LGGTCLNVGC IPSKALLNNS HLFHQMHTEA QKRGIDVNGD IKINVANFQK AKDDAVKQLT 120
  121 GGIELLFKKN KVTYYKGNGS FEDETKIRVT PVDGLEGTVK EDHILDVKNI IVATGSEVTP 180
  181 FPGIEIDEEK IVSSTGALSL KEIPKRLTII GGGIIGLEMG SVYSRLGSKV TVVEFQPQIG 240
  241 ASMDGEVAKA TQKFLKKQGL DFKLSTKVIS AKRNDDKNVV EIVVEDTKTN KQENLEAEVL 300
  301 LVAVGRRPYI AGLGAEKIGL EVDKRGRLVI DDQFNSKFPH IKVVGDVTFG PMLAHKAEEE 360
  361 GIAAVEMLKT GHGHVNYNNI PSVMYSHPEV AWVGKTEEQL KEAGIDYKIG KFPFAANSRA 420
  421 KTNQDTEGFV KILIDSKTER ILGAHIIGPN AGEMIAEAGL ALEYGASAED VARVCHAHPT 480
  481 LSEAFKEANM AAYDKAIHC

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) KGD1 KGD2 LAT1 LPD1 PDB1 YMR31
    View Details (MIPS) Mewes HW, et al. (2004) GCV1 GCV2 GCV3 KGD1 KGD2 LAT1 LPD1 PDA1 PDB1 PDX1
    View Details Krogan NJ, et al. (2006) LPD1 YMR31
    View Details Gavin AC, et al. (2002) APM1 CLU1 CYM1 DOA4 DUR1,2 HSP42 KAP123 KGD1 KGD2 LAT1 LEA1 LPD1 PDA1 PDB1 PDX1 PRP46 RPN11 SAM1 TCM62 YMR31
    View Details Ho Y, et al. (2002) AFG3 ARC1 ARG1 CDC10 CDC11 CDC12 CDC3 CDC33 COR1 ENP1 KGD2 KRS1 LPD1 PMI40 RVB2 RVS161 RVS167 SES1 TRP5
    View Details Qiu et al. (2008) ALD4 ATP1 GCV1 GCV2 GCV3 ILV5 KGD1 LAT1 LPD1 MDH1 PDA1 PDB1 PDX1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run BOI2 Boi 2 gst control McCusker D, et al (2007)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LPD1 Huh WK, et al. (2003)
    View Data LPD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..68]
    [117..177]
    [307..377]    		 PSI-BLAST 10160.0 Dihydrolipoamide dehydrogenase
    2 View Details [69..116]
    [178..306]
    [378..383]    		 PSI-BLAST 10160.0 Dihydrolipoamide dehydrogenase
    3 View Details [384..499] PSI-BLAST 10160.0 Dihydrolipoamide dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • pyruvate dehydrogenase activity
    		•  8.42473605174108 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  8.07008457237017 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  7.86778387378753 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  7.84550673347799 bayes_pls_golite062009
  • lipoamide binding
    		•  7.21320397413054 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  6.68894387221662 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  6.56425883527182 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  6.2758493127081 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  6.2758493127081 bayes_pls_golite062009
  • oxoglutarate dehydrogenase (succinyl-transferring) activity
    		•  5.32373368820399 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  4.48151296542899 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  4.19923051777224 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  4.05603184984386 bayes_pls_golite062009
  • antioxidant activity
    		•  3.99666840824738 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.78622758776028 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  3.68406278988218 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.50748163367583 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  3.23754178295825 bayes_pls_golite062009
  • oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
    		•  3.15456908604913 bayes_pls_golite062009
  • thioredoxin-disulfide reductase activity
    		•  3.04300775355641 bayes_pls_golite062009
  • glutathione binding
    		•  2.84679371365652 bayes_pls_golite062009
  • glutathione-disulfide reductase activity
    		•  2.72350669229836 bayes_pls_golite062009
  • oxidoreductase activity, oxidizing metal ions
    		•  2.49798084628282 bayes_pls_golite062009
  • tubulin binding
    		•  2.40546880499445 bayes_pls_golite062009
  • catalytic activity
    		•  2.35839632763616 bayes_pls_golite062009
  • microtubule binding
    		•  2.30064869971937 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.23446140524739 bayes_pls_golite062009
  • peptide disulfide oxidoreductase activity
    		•  2.13269617402519 bayes_pls_golite062009
  • glutathione disulfide oxidoreductase activity
    		•  2.13269617402519 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.87417564758524 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors
    		•  1.71836807554864 bayes_pls_golite062009
  • binding
    		•  1.50672625307126 bayes_pls_golite062009
  • oxygen-dependent protoporphyrinogen oxidase activity
    		•  1.42994468012845 bayes_pls_golite062009
  • protein binding
    		•  1.21627488765992 bayes_pls_golite062009
  • transporter activity
    		•  1.16027171869703 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.04563737396213 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.992020263296138 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.886337714694097 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.795364404071999 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.718226588475577 bayes_pls_golite062009
  • NADPH-adrenodoxin reductase activity
    		•  0.684108511779641 bayes_pls_golite062009
  • transferase activity
    		•  0.649374189439191 bayes_pls_golite062009
  • electron carrier activity
    		•  0.511623955786613 bayes_pls_golite062009
  • succinate dehydrogenase activity
    		•  0.110826254138262 bayes_pls_golite062009
  • coenzyme binding
    		•  0.10945648874523 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.80

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle