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View Structure Prediction Details

Protein: LPD1
Organism: Saccharomyces cerevisiae
Length: 499 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LPD1.

Description E-value Query
Range		 Subject
Range
LPD1 - Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydroge...
DLDH_YEAST - Dihydrolipoyl dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...
 0.0 [1..499] [1..499]
gi|8778521, gi|2... - gi|8778521|gb|AAF79529.1|AC023673_17 F21D18.28 [Arabidopsis thaliana], pir||F96520 dihydrolipoamide ...
 0.0 [3..498] [23..504]
DLDH_PEA - Dihydrolipoyl dehydrogenase, mitochondrial OS=Pisum sativum GN=LPD PE=1 SV=2
 0.0 [2..498] [20..500]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [2..496] [20..498]
gi|10444388 - gi|10444388|gb|AAG17888.1| dihydrolipoamide dehydrogenase precursor [Solanum tuberosum]
 0.0 [7..498] [21..503]
DLDH_SCHPO - Dihydrolipoyl dehydrogenase, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN...
dld1 - dihydrolipoamide dehydrogenase Dld1
 0.0 [20..498] [39..510]

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Predicted Domain #1
Region A:
Residues: [1-68] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRIRSLLNN KRAFSSTVRT LTINKSHDVV IIGGGPAGYV AAIKAAQLGF NTACVEKRGK  60
   61 LGGTCLNV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [117-177] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQLTGGIELL FKKNKVTYYK GNGSFEDETK IRVTPVDGLE GTVKEDHILD VKNIIVATGS  60
   61 E

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [307-377] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPYIAGLGAE KIGLEVDKRG RLVIDDQFNS KFPHIKVVGD VTFGPMLAHK AEEEGIAAVE  60
   61 MLKTGHGHVN Y

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10160.0
Match: 1jehA_
Description: Dihydrolipoamide dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
pyruvate dehydrogenase activity 8.42473605174108 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 8.07008457237017 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 7.86778387378753 bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity 7.84550673347799 bayes_pls_golite062009
lipoamide binding 7.21320397413054 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor 6.68894387221662 bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity 6.56425883527182 bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity 6.2758493127081 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor 6.2758493127081 bayes_pls_golite062009
oxoglutarate dehydrogenase (succinyl-transferring) activity 5.32373368820399 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 4.48151296542899 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 4.19923051777224 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 4.05603184984386 bayes_pls_golite062009
antioxidant activity 3.99666840824738 bayes_pls_golite062009
oxidoreductase activity 3.78622758776028 bayes_pls_golite062009
NADH dehydrogenase activity 3.68406278988218 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 3.50748163367583 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 3.23754178295825 bayes_pls_golite062009
oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor 3.15456908604913 bayes_pls_golite062009
thioredoxin-disulfide reductase activity 3.04300775355641 bayes_pls_golite062009
glutathione binding 2.84679371365652 bayes_pls_golite062009
glutathione-disulfide reductase activity 2.72350669229836 bayes_pls_golite062009
oxidoreductase activity, oxidizing metal ions 2.49798084628282 bayes_pls_golite062009
tubulin binding 2.40546880499445 bayes_pls_golite062009
catalytic activity 2.35839632763616 bayes_pls_golite062009
microtubule binding 2.30064869971937 bayes_pls_golite062009
cytoskeletal protein binding 2.23446140524739 bayes_pls_golite062009
peptide disulfide oxidoreductase activity 2.13269617402519 bayes_pls_golite062009
glutathione disulfide oxidoreductase activity 2.13269617402519 bayes_pls_golite062009
disulfide oxidoreductase activity 1.87417564758524 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors 1.71836807554864 bayes_pls_golite062009
binding 1.50672625307126 bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity 1.42994468012845 bayes_pls_golite062009
protein binding 1.21627488765992 bayes_pls_golite062009
transporter activity 1.16027171869703 bayes_pls_golite062009
transmembrane transporter activity 1.04563737396213 bayes_pls_golite062009
substrate-specific transporter activity 0.992020263296138 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.886337714694097 bayes_pls_golite062009
ion transmembrane transporter activity 0.795364404071999 bayes_pls_golite062009
cation transmembrane transporter activity 0.718226588475577 bayes_pls_golite062009
NADPH-adrenodoxin reductase activity 0.684108511779641 bayes_pls_golite062009
transferase activity 0.649374189439191 bayes_pls_golite062009
electron carrier activity 0.511623955786613 bayes_pls_golite062009
succinate dehydrogenase activity 0.110826254138262 bayes_pls_golite062009
coenzyme binding 0.10945648874523 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [69-116] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GCIPSKALLN NSHLFHQMHT EAQKRGIDVN GDIKINVANF QKAKDDAV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [178-306] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTPFPGIEID EEKIVSSTGA LSLKEIPKRL TIIGGGIIGL EMGSVYSRLG SKVTVVEFQP  60
   61 QIGASMDGEV AKATQKFLKK QGLDFKLSTK VISAKRNDDK NVVEIVVEDT KTNKQENLEA 120
  121 EVLLVAVGR

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [378-383] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNIPSV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10160.0
Match: 1jehA_
Description: Dihydrolipoamide dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [384-499] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYSHPEVAWV GKTEEQLKEA GIDYKIGKFP FAANSRAKTN QDTEGFVKIL IDSKTERILG  60
   61 AHIIGPNAGE MIAEAGLALE YGASAEDVAR VCHAHPTLSE AFKEANMAAY DKAIHC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10160.0
Match: 1jehA_
Description: Dihydrolipoamide dehydrogenase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle