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Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions. Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide bonds. Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor. Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: glutathione-disulfide reductase activity
Acc: GO:0004362
Aspect: Molecular Function
Desc: Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.
Synonyms:
  • glutathione reductase activity
  • NADPH-glutathione reductase activity
  • NADPH-GSSG reductase activity
  • glutathione S-reductase activity
  • NADPH:oxidized-glutathione oxidoreductase activity
  • glutathione reductase (NADPH) activity
  • glutathione-disulphide reductase activity
  • GSSG reductase activity
  • oxidized glutathione reduction
  • GSH reductase activity
  • glutathione:NADP+ oxidoreductase activity
Proteins in PDR annotated with:
   This term: 21 [Search]
   Term or descendants: 21 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004362 - glutathione-disulfide reductase activity (interactive image map)
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