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Protein Overview: ECM2

General Information:
Name(s) found: ECM2 / YBR065C [SGD]
Description(s) found:
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  • gi|6319539|ref|NP_009621.1| Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p; Ecm2p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S45925 hypothetical protein YBR065c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|586504|sp|P38241.1|SLT11_YEAST RecName: Full=Pre-mRNA-splicing factor SLT11; AltName: Full=Synthetic lethality with U2 protein 11; AltName: Full=Extracellular mutant protein 2 [NCBI NR]
  • gi|536310|emb|CAA85008.1| ECM2 [Saccharomyces cerevisiae] [NCBI NR]
  • Pre-mRNA-splicing factor SLT11 OS=Saccharomyces cerevisiae GN=ECM2 PE=1 SV=1 [Swiss-Prot]
  • (P38241) Splicing factor SLT11 (ECM2 protein) [Swiss-Prot]
  • ECM2 Protein involved in cell wall biogenesis and architecture [mips]
  • Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p [SGD]
  • ECM2, Chr II from 368544-369638, reverse complement [yeast_orfs2]
  • Chr II from 368544-369638, reverse complement [yeastorf3.fasta]
  • Chr II from 369638-368544, reverse complement [yeastorf5.fasta]
  • (P38241) Hypothetical 40.9 kDa protein in ORC2-TIP1 intergenic region [4932.FASTACCERV.txt]
  • ECM2 SGDID:S0000269, Chr II from 369639-368545, reverse complement, Verified ORF [yeastflysequest.fasta]
  • ECM2 SGDID:S0000269, Chr II from 369676-368582, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Ecm2p [Saccharomyces cerevisiae]gi|536310|emb|CAA85008.1| ECM2 [Saccharomyces cerevisiae]gi|626505|pir||S45925 hypothetical protein YBR065c - yeast (Saccharomyces cerevisiae)gi|586504|sp|P38241|SL11_YEAST Splicing factor SLT11 (ECM2 protein) [nrdb_11152004_Chlamydomonas]
  • ECM2 SGDID:S000000269, Chr II from 369676-368582, reverse complement, Verified ORF, "Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Pre-mRNA-splicing factor SLT11 (Synthetic lethality with U2 protein 11) (Extracellular matrix protein 2) [nr-271106-contam.fasta]
  • Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p; Ecm2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ECM2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Pre-mRNA-splicing factor SLT11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ECM2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ECM2 SGDID:S000000269, Chr II from 369678-368584, Genome Release 64-1-1, reverse complement, Verified ORF, "Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p" [yeast-030211-contam.fasta]
  • ECM2 SGDID:S000000269, Chr II from 369678-368584, Genome Release 64-2-1, reverse complement, Verified ORF, "Pre-mRNA splicing factor; facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p" [20141208_orf_trans.fasta]
  • YBR065C SGDID:S000000269, Chr II from 369678-368584, Genome Release 64-1-1, reverse complement, Verified ORF, "Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 364 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: cellular cell wall organization [IMPLink to PubMed article]
    nuclear mRNA splicing, via spliceosome [IGILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDEINEPPP NICEQCLGDE ANIRMTKIPQ GSECKICTLP FTLYHFKTSK RSNNIIKTLI  60
   61 CVRCATQRNI CQCCMLDSRW HIPIQLRDHL ISLVNEENVM TEEAKNDMMK RFLSLKNVKL 120
  121 GGAQITSDPS EADNIVDKLK NILLRATSDG PSTPLIKNTT ALYKNEKGAN EVKNLEKYAS 180
  181 VDISHILKKL PLNESFLKNP STKSFFLYNI DASIPEWKIT DTVSQLLGIK KWKDGNSLSL 240
  241 IVNHKAKCGG LRFQSSELGE RFVSKISETL VTPKGLKRGV LLIDRFRIFI IPWSSGFSAA 300
  301 SFGTNTAENI KLSLSLNKLI QLELGLSFPT KSTDNAKNDK KKTSKKVHKD RSKKSKPRAN 360
  361 KLTI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CWC2 CWC23 ECM2 HSH155 LEA1 PRP19 PRP43 PRP46 PRP9 RSE1 SNT309 SNU114 SYF1
    View Details Hazbun TR, et al. (2003) BRR2 CDC40 CEF1 CLF1 CWC2 CWC22 CWC23 ECM2 ISY1 LEA1 NTR2 PRP19 PRP43 PRP45 PRP46 PRP8 SMB1 SMD1 SMD3 SMX3 SNT309 SNU114 SPP382 SYF1 SYF2 YJU2
    View Details Krogan NJ, et al. (2006) ADE8 CHZ1 ECM2 HCR1 HEM12 KAP122 NIP1 PRT1 RPG1 SUI1 SYH1 TIF34 TIF35 TIF5 YOR052C
    View Details Gavin AC, et al. (2006) CDC40 CEF1 CLF1 CWC2 CWC22 ECM2 PRP19 PRP45 PRP46 SYF1
    View Details Gavin AC, et al. (2002) AAR2 BRR1 BUD31 CBC2 CDC33 CDC40 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DHH1 DIB1 ECM2 GCN2 HRT1 HSH155 HSH49 HTA1 IMG1 ISY1 LEA1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 NAM8 NPL3 PAT1 PRP11 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 STO1 SYF1 TIF4631 TIF4632 TOS4 UTP21 YEF3 YML6
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CEF1 CLF1 CUS1 CWC15 CWC2 CWC22 CWC23 DHR2 ECM2 ISY1 LSM4 LUC7 MAK5 MUD1 MUD2 NAM8 PRP16 PRP18 PRP2 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP45 PRP5 PRP6 PRP8 PRP9 SLU7 SMB1 SMD1 SME1 SNU114 SNU23 SPP2 SPP381 STO1 SYF2 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CWC2 No Comments Hazbun TR, et al. (2003)
    View Run SPP382 No Comments Hazbun TR, et al. (2003)
    View Run SPP382 No Comments Hazbun TR, et al. (2003)
    View Run CWC25 No Comments Hazbun TR, et al. (2003)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen URN1 ECM2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ECM2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91] deduced N/A No confident structure predictions are available.
    2 View Details [92..198] PSI-BLAST 48.154902 Poly(A)-binding protein
    3 View Details [199..287] PSI-BLAST 48.154902 Poly(A)-binding protein
    4 View Details [288..364] PSI-BLAST 52.221849 Nuclear ribonucleoprotein A1 (RNP A1, UP1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.74860109511336 bayes_pls_golite062009
  • catalytic activity
    		•  0.223774911842048 bayes_pls_golite062009
    2
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
    		• 6.62953239642182 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.81920018903278 bayes_pls_golite062009
  • binding
    		•  3.49612884560266 bayes_pls_golite062009
  • snRNA binding
    		•  3.28448936696877 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • U1 snRNA binding
    		•  2.26303528058407 bayes_pls_golite062009
  • protein binding
    		•  1.32954276279597 bayes_pls_golite062009
  • structural molecule activity
    		•  1.29928829870122 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07788694919471 bayes_pls_golite062009
  • DNA binding
    		•  0.978604858165557 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • transcription factor activity
    		•  0.234742017105535 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle