YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes:	This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Fkh1. The topolgies of protein complexes in this experiment are unknown.
Complex Size:	27 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
CDC28	nucleus cytoplasm ribosome	G2/M transition of mitotic cell cycle transcription S phase of mitotic cell cycle G1/S transition of mitotic cell cycle regulation of meiosis protein amino acid phosphorylation	cyclin-dependent protein kinase activity
CEG1	nucleus	mRNA capping positive regulation of transcription from RNA polymerase II promoter	mRNA guanylyltransferase activity
CKA1	protein kinase CK2 complex	G2/M transition of mitotic cell cycle G1/S transition of mitotic cell cycle flocculation via cell wall protein-carbohydrate interaction protein amino acid phosphorylation response to DNA damage stimulus regulation of transcription from RNA polymerase III promoter regulation of transcription from RNA polymerase I promoter cellular ion homeostasis	protein kinase CK2 activity
CKA2	protein kinase CK2 complex	G2/M transition of mitotic cell cycle G1/S transition of mitotic cell cycle flocculation via cell wall protein-carbohydrate interaction protein amino acid phosphorylation response to DNA damage stimulus regulation of transcription from RNA polymerase III promoter regulation of transcription from RNA polymerase I promoter cellular ion homeostasis	protein kinase CK2 activity
CKB1	protein kinase CK2 complex	G2/M transition of mitotic cell cycle G1/S transition of mitotic cell cycle flocculation via cell wall protein-carbohydrate interaction protein amino acid phosphorylation response to DNA damage stimulus regulation of transcription from RNA polymerase III promoter regulation of transcription from RNA polymerase I promoter cellular ion homeostasis	protein kinase CK2 regulator activity
CKB2	protein kinase CK2 complex	G2/M transition of mitotic cell cycle G1/S transition of mitotic cell cycle flocculation via cell wall protein-carbohydrate interaction protein amino acid phosphorylation response to DNA damage stimulus regulation of transcription from RNA polymerase III promoter regulation of transcription from RNA polymerase I promoter cellular ion homeostasis	protein kinase CK2 regulator activity
FKH1	nucleus	pseudohyphal growth negative regulation of cell cycle positive regulation of cell cycle regulation of transcription involved in G2/M-phase of mitotic cell cycle termination of RNA polymerase II transcription donor selection chromatin silencing at silent mating-type cassette RNA elongation from RNA polymerase II promoter	DNA binding specific RNA polymerase II transcription factor activity centromeric DNA binding
FYV8	cytoplasm	biological_process	molecular_function
GCD2	guanyl-nucleotide exchange factor complex eukaryotic translation initiation factor 2B complex	regulation of translational initiation	translation initiation factor activity guanyl-nucleotide exchange factor activity enzyme regulator activity
GCD7	mitochondrion guanyl-nucleotide exchange factor complex eukaryotic translation initiation factor 2B complex	regulation of translational initiation	translation initiation factor activity guanyl-nucleotide exchange factor activity enzyme regulator activity
GCN3	guanyl-nucleotide exchange factor complex eukaryotic translation initiation factor 2B complex	regulation of translational initiation	translation initiation factor activity guanyl-nucleotide exchange factor activity enzyme regulator activity
HHF1, HHF2	nucleus nucleoplasm part nuclear nucleosome chromosome replication fork protection complex chromatin remodeling complex nucleosome histone acetyltransferase complex nucleoplasm	histone H3-K79 methylation DNA repair negative regulation of transcription chromatin assembly or disassembly positive regulation of transcription nucleosome assembly	DNA binding
HTB1	nuclear nucleosome	chromatin assembly or disassembly postreplication repair	DNA binding
MBP1	nucleus	DNA replication	DNA binding transcription factor activity transcription repressor activity
MGM101	mitochondrial chromosome mitochondrion mitochondrial nucleoid	DNA repair mitochondrial genome maintenance	DNA binding
MPH1	nucleus	DNA repair	RNA helicase activity 3'-5' DNA helicase activity
NET1	RENT complex nucleolus	chromatin silencing at rDNA nucleolus organization regulation of exit from mitosis	rDNA binding
NOP1	nuclear outer membrane nucleolus ribosome small nucleolar ribonucleoprotein complex	rRNA modification RNA methylation maturation of SSU-rRNA ribosome biogenesis ribosomal large subunit assembly snoRNA 3'-end processing	methyltransferase activity
RRP1	nucleus nucleolus	ribosome biogenesis rRNA processing	molecular_function
SEC2	cytosol cytoplasmic membrane-bounded vesicle	exocytosis	guanyl-nucleotide exchange factor activity
SIN3	Sin3 complex histone deacetylase complex	negative regulation of transcription from RNA polymerase II promoter chromatin silencing at rDNA telomere maintenance double-strand break repair via nonhomologous end joining histone deacetylation chromatin silencing at silent mating-type cassette positive regulation of transcription from RNA polymerase II promoter chromatin silencing at telomere	transcription coactivator activity histone deacetylase activity transcription corepressor activity
SUI2	multi-eIF complex cytoplasm ribosome eukaryotic translation initiation factor 2 complex	translational initiation	translation initiation factor activity
SUI3	multi-eIF complex ribosome eukaryotic translation initiation factor 2 complex	translational initiation	translation initiation factor activity
UBP12	nucleus cytoplasm	biological_process	ubiquitin-specific protease activity
URE2	soluble fraction cytosol	response to aluminum ion telomere maintenance regulation of nitrogen utilization protein urmylation cytoplasmic sequestering of transcription factor	transcription corepressor activity phosphoprotein binding
YGR017W	nucleus cytoplasm	biological_process	molecular_function
YMR144W	nucleus	biological_process	molecular_function

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
protein kinase CK2 complex	2.69E-10	27	4	4	6292
eukaryotic translation initiation factor 2B complex	7.0086E-7	27	5	3	6292
guanyl-nucleotide exchange factor complex	2.439E-6	27	7	3	6292
eukaryotic translation initiation factor 2 complex	5.3064E-5	27	3	2	6292
multi-eIF complex	4.8874E-4	27	8	2	6292
macromolecular complex	1.019E-3	27	1635	15	6292
nuclear nucleosome	1.1399E-3	27	12	2	6292
nucleosome	1.1399E-3	27	12	2	6292
protein complex	1.3681E-3	27	1137	12	6292
intracellular part	1.4188E-3	27	4938	27	6292
intracellular	1.7365E-3	27	4975	27	6292
nuclear chromatin	3.5888E-3	27	73	3	6292
chromatin	4.173E-3	27	77	3	6292
non-membrane-bounded organelle	4.5823E-3	27	959	10	6292
intracellular non-membrane-bounded organelle	4.5823E-3	27	959	10	6292
chromatin remodeling complex	8.4043E-3	27	99	3	6292
mitochondrial chromosome	8.5646E-3	27	2	1	6292
cytoplasmic chromosome	8.5646E-3	27	2	1	6292
replication fork protection complex	8.5646E-3	27	2	1	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
regulation of transcription from RNA polymerase I promoter	2.69E-10	27	4	4	6292
G2/M transition of mitotic cell cycle	1.531E-9	27	29	6	6292
regulation of transcription from RNA polymerase III promoter	9.3325E-9	27	7	4	6292
flocculation via cell wall protein-carbohydrate interaction	5.5505E-8	27	10	4	6292
flocculation	8.6967E-8	27	11	4	6292
regulation of gene expression	8.852E-8	27	445	12	6292
regulation of macromolecule biosynthetic process	1.1606E-7	27	456	12	6292
regulation of cellular biosynthetic process	1.6992E-7	27	472	12	6292
regulation of biosynthetic process	1.7394E-7	27	473	12	6292
regulation of macromolecule metabolic process	2.4528E-7	27	488	12	6292
response to DNA damage stimulus	3.2769E-7	27	236	9	6292
regulation of primary metabolic process	4.3305E-7	27	514	12	6292
regulation of cellular metabolic process	6.8337E-7	27	536	12	6292
translational initiation	7.512E-7	27	42	5	6292
regulation of metabolic process	8.5168E-7	27	547	12	6292
regulation of cellular process	9.834E-7	27	796	14	6292
regulation of biological process	1.5073E-6	27	824	14	6292
gene expression	1.7162E-6	27	1283	17	6292
G1/S transition of mitotic cell cycle	1.8277E-6	27	50	5	6292
cellular response to stress	1.8666E-6	27	290	9	6292
cellular macromolecule metabolic process	1.9212E-6	27	2285	22	6292
interphase of mitotic cell cycle	2.6185E-6	27	97	6	6292
interphase	2.6185E-6	27	97	6	6292
macromolecule metabolic process	3.2831E-6	27	2349	22	6292
cellular macromolecule biosynthetic process	3.7216E-6	27	1187	16	6292
macromolecule biosynthetic process	3.8087E-6	27	1189	16	6292
transcription from RNA polymerase I promoter	6.831E-6	27	30	4	6292
nucleic acid metabolic process	7.1603E-6	27	1415	17	6292
regulation of translational initiation	1.1367E-5	27	11	3	6292
cellular response to stimulus	1.6843E-5	27	379	9	6292
transcription from RNA polymerase III promoter	1.7973E-5	27	38	4	6292
regulation of transcription	1.8722E-5	27	384	9	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	3.0345E-5	27	1566	17	6292
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	3.4873E-5	27	415	9	6292
regulation of nitrogen compound metabolic process	3.5548E-5	27	416	9	6292
transcription	5.3109E-5	27	552	10	6292
protein amino acid phosphorylation	6.4652E-5	27	103	5	6292
mitotic cell cycle	7.3148E-5	27	255	7	6292
post-translational protein modification	8.4989E-5	27	357	8	6292
regulation of transcription, DNA-dependent	8.6689E-5	27	358	8	6292
regulation of RNA metabolic process	9.5623E-5	27	363	8	6292
response to stress	1.4344E-4	27	497	9	6292
biological regulation	1.4628E-4	27	1213	14	6292
cellular biosynthetic process	1.49E-4	27	1567	16	6292
cellular nitrogen compound metabolic process	1.6421E-4	27	1770	17	6292
primary metabolic process	1.6837E-4	27	2896	22	6292
cellular protein metabolic process	1.8352E-4	27	1074	13	6292
nitrogen compound metabolic process	1.9252E-4	27	1791	17	6292
biosynthetic process	1.9729E-4	27	1602	16	6292
protein metabolic process	3.2877E-4	27	1136	13	6292
cellular metabolic process	3.8731E-4	27	3033	22	6292
macromolecule modification	4.0148E-4	27	569	9	6292
metabolic process	7.8688E-4	27	3157	22	6292
cell cycle phase	8.0472E-4	27	376	7	6292
response to stimulus	8.1226E-4	27	766	10	6292
protein modification process	8.4937E-4	27	499	8	6292
phosphorylation	8.5501E-4	27	179	5	6292
transcription, DNA-dependent	8.9559E-4	27	503	8	6292
RNA biosynthetic process	9.5622E-4	27	508	8	6292
DNA repair	1.1729E-3	27	192	5	6292
cellular ion homeostasis	1.5248E-3	27	119	4	6292
cellular chemical homeostasis	1.5248E-3	27	119	4	6292
cellular homeostasis	1.5727E-3	27	120	4	6292
chemical homeostasis	1.7229E-3	27	123	4	6292
ion homeostasis	1.7229E-3	27	123	4	6292
regulation of translation	1.7672E-3	27	57	3	6292
posttranscriptional regulation of gene expression	2.149E-3	27	61	3	6292
DNA metabolic process	2.3925E-3	27	585	8	6292
positive regulation of cellular process	2.4907E-3	27	136	4	6292
positive regulation of biological process	2.5581E-3	27	137	4	6292
phosphorus metabolic process	2.5603E-3	27	229	5	6292
phosphate metabolic process	2.5603E-3	27	229	5	6292
chromatin silencing at rDNA	2.6008E-3	27	18	2	6292
regulation of cellular protein metabolic process	2.9333E-3	27	68	3	6292
multi-organism process	2.9892E-3	27	143	4	6292
regulation of protein metabolic process	3.7298E-3	27	74	3	6292
cell cycle process	3.7405E-3	27	490	7	6292
negative regulation of biological process	3.9426E-3	27	253	5	6292
histone H3-K79 methylation	4.2912E-3	27	1	1	6292
negative regulation of intracellular protein transport	4.2912E-3	27	1	1	6292
negative regulation of nucleocytoplasmic transport	4.2912E-3	27	1	1	6292
negative regulation of protein import into nucleus	4.2912E-3	27	1	1	6292
negative regulation of intracellular transport	4.2912E-3	27	1	1	6292
response to aluminum ion	4.2912E-3	27	1	1	6292
regulation of transcription factor import into nucleus	4.2912E-3	27	1	1	6292
transcription factor import into nucleus	4.2912E-3	27	1	1	6292
negative regulation of transcription factor import into nucleus	4.2912E-3	27	1	1	6292
cytoplasmic sequestering of transcription factor	4.2912E-3	27	1	1	6292
RNA metabolic process	4.4086E-3	27	954	10	6292
negative regulation of transcription	4.889E-3	27	164	4	6292
negative regulation of gene expression	4.889E-3	27	164	4	6292
cell cycle	5.4905E-3	27	525	7	6292
negative regulation of macromolecule biosynthetic process	6.152E-3	27	175	4	6292
homeostatic process	6.5996E-3	27	408	6	6292
negative regulation of nitrogen compound metabolic process	6.7922E-3	27	180	4	6292
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	6.7922E-3	27	180	4	6292
regulation of biological quality	7.1513E-3	27	551	7	6292
negative regulation of biosynthetic process	8.0541E-3	27	189	4	6292
negative regulation of cellular biosynthetic process	8.0541E-3	27	189	4	6292
negative regulation of macromolecule metabolic process	8.507E-3	27	192	4	6292
histone lysine methylation	8.5646E-3	27	2	1	6292
nucleolus organization	8.5646E-3	27	2	1	6292
regulation of nucleocytoplasmic transport	8.5646E-3	27	2	1	6292
regulation of protein import into nucleus	8.5646E-3	27	2	1	6292
regulation of intracellular transport	8.5646E-3	27	2	1	6292
negative regulation of protein transport	8.5646E-3	27	2	1	6292
cytoplasmic sequestering of protein	8.5646E-3	27	2	1	6292
regulation of intracellular protein transport	8.5646E-3	27	2	1	6292
chromatin silencing at silent mating-type cassette	8.627E-3	27	33	2	6292
negative regulation of gene expression, epigenetic	8.6396E-3	27	100	3	6292
gene silencing	8.6396E-3	27	100	3	6292
regulation of gene expression, epigenetic	8.6396E-3	27	100	3	6292
chromatin silencing	8.6396E-3	27	100	3	6292
chromatin assembly or disassembly	9.6706E-3	27	35	2	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
translation initiation factor activity	7.4487E-8	27	27	5	6292
translation factor activity, nucleic acid binding	9.5342E-7	27	44	5	6292
protein kinase CK2 activity	1.7735E-5	27	2	2	6292
protein kinase CK2 regulator activity	1.7735E-5	27	2	2	6292
guanyl-nucleotide exchange factor activity	1.7973E-5	27	38	4	6292
nucleic acid binding	4.5696E-5	27	666	11	6292
obsolete_molecular_function	1.9221E-4	27	69	4	6292
GTPase regulator activity	4.1053E-4	27	84	4	6292
DNA binding	6.1536E-4	27	256	6	6292
nucleoside-triphosphatase regulator activity	6.5586E-4	27	95	4	6292
transcription repressor activity	8.3017E-4	27	44	3	6292
binding	1.2199E-3	27	1294	13	6292
transcription corepressor activity	2.0507E-3	27	16	2	6292
phosphoprotein binding	4.2912E-3	27	1	1	6292
mRNA guanylyltransferase activity	4.2912E-3	27	1	1	6292
RNA guanylyltransferase activity	8.5646E-3	27	2	1	6292
3'-5' DNA helicase activity	8.5646E-3	27	2	1	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis