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Any process by which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane. The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells by means of some external agent such as a transporter or pore. Any process by which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. Any process by which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away. Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells by means of some external agent such as a transporter or pore.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: cytoplasmic sequestering of protein
Acc: GO:0051220
Aspect: Biological Process
Desc: The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell.
Synonyms:
  • cytoplasmic retention of protein
  • retention of protein in cytoplasm
  • cytoplasmic sequestration of protein
  • cytoplasmic storage of protein
  • storage of protein in cytoplasm
  • sequestering of protein in cytoplasm
  • sequestration of protein in cytoplasm
  • maintenance of protein location in cytoplasm
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 19 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0051220 - cytoplasmic sequestering of protein (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle