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View Protein Complex Details

Complex Overview

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRR1
  • small nuclear ribonucleoprotein complex
  • spliceosome assembly
  • RNA binding
  • CBC2
  • commitment complex
  • nuclear cap binding complex
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
  • RNA cap binding
  • CDC33
  • nucleus
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • translational initiation
  • translation initiation factor activity
  • CLF1
  • chromatin
  • DNA replication
  • cell cycle
  • cis assembly of pre-catalytic spliceosome
  • nuclear mRNA splicing, via spliceosome
  • protein binding
  • CSN12
  • signalosome
  • adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
  • molecular_function
  • CUS1
  • U2 snRNP
  • spliceosome assembly
  • RNA binding
  • protein binding
  • CWC2
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • DIB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • ECM2
  • nucleus
  • cellular cell wall organization
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • HSH155
  • U2 snRNP
  • spliceosome assembly
  • mRNA binding
  • LEA1
  • cytoplasm
  • U2 snRNP
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • LSM4
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LUC7
  • U1 snRNP
  • mRNA splice site selection
  • mRNA binding
  • MSL1
  • U2 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • MUD1
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • NAM8
  • commitment complex
  • U1 snRNP
  • mRNA splice site selection
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • mRNA binding
  • NPL3
  • nucleus
  • cytoplasm
  • mRNA export from nucleus
  • pseudohyphal growth
  • poly(A) RNA binding
  • mRNA binding
  • PRP11
  • U2 snRNP
  • spliceosome assembly
  • RNA binding
  • PRP19
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • first spliceosomal transesterification activity
  • RNA binding
  • PRP21
  • U2 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PRP3
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP31
  • mitochondrion
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • PRP39
  • commitment complex
  • U1 snRNP
  • nuclear mRNA 5'-splice site recognition
  • pre-mRNA 5'-splice site binding
  • PRP4
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP40
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PRP42
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PRP43
  • mitochondrion
  • spliceosomal complex
  • nuclear outer membrane
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • processing of 27S pre-rRNA
  • ATP-dependent RNA helicase activity
  • PRP46
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP6
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • binding
  • molecular_function
  • PRP9
  • U2 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • RSE1
  • U2 snRNP
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
  • U2 snRNA binding
  • SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD1
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SMD2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD3
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SME1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMX2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMX3
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SNP1
  • commitment complex
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • U1 snRNA binding
  • mRNA binding
  • SNT309
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • protein binding
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • SNU56
  • commitment complex
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SNU66
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SNU71
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • SPP382
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • SRB2
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • STO1
  • commitment complex
  • nuclear cap binding complex
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • TIF4631
  • eukaryotic translation initiation factor 4F complex
  • mitochondrion
  • ribosome
  • ribosome biogenesis
  • translational initiation
  • translation initiation factor activity
  • TIF4632
  • eukaryotic translation initiation factor 4F complex
  • ribosome
  • translational initiation
  • translation initiation factor activity
  • YEF3
  • ribosome
  • ribosome biogenesis
  • translational elongation
  • translation elongation factor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    small nuclear ribonucleoprotein complex 3.2278E-58 50 63 33 6292
    ribonucleoprotein complex 2.6003E-44 50 514 45 6292
    U1 snRNP 2.9431E-34 50 17 16 6292
    nuclear part 4.3003E-26 50 1103 43 6292
    macromolecular complex 1.5717E-24 50 1635 47 6292
    U4/U6 x U5 tri-snRNP complex 1.6149E-24 50 32 15 6292
    spliceosomal complex 7.6874E-20 50 45 14 6292
    nucleus 1.1733E-18 50 2041 46 6292
    U5 snRNP 1.15E-16 50 14 9 6292
    U2-type spliceosomal complex 4.2783E-15 50 12 8 6292
    commitment complex 4.2783E-15 50 12 8 6292
    U2 snRNP 1.1058E-14 50 13 8 6292
    intracellular organelle part 3.8154E-14 50 2282 44 6292
    organelle part 3.8154E-14 50 2282 44 6292
    intracellular organelle 3.1175E-10 50 4070 50 6292
    organelle 3.1563E-10 50 4071 50 6292
    membrane-bounded organelle 4.4761E-8 50 3771 47 6292
    intracellular membrane-bounded organelle 4.4761E-8 50 3771 47 6292
    eukaryotic translation initiation factor 4F complex 1.8787E-6 50 4 3 6292
    intracellular part 5.1855E-6 50 4938 50 6292
    intracellular 7.5457E-6 50 4975 50 6292
    nuclear cap binding complex 1.8474E-4 50 3 2 6292
    cell part 4.509E-4 50 5397 50 6292
    cell 4.5937E-4 50 5399 50 6292
    RNA cap binding complex 9.0969E-4 50 6 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 3.7279E-72 50 99 42 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 6.4193E-72 50 100 42 6292
    RNA splicing, via transesterification reactions 2.3832E-70 50 107 42 6292
    RNA splicing 1.1686E-65 50 132 42 6292
    mRNA processing 4.4235E-62 50 156 42 6292
    mRNA metabolic process 5.9552E-58 50 213 43 6292
    RNA processing 2.5544E-46 50 380 43 6292
    RNA metabolic process 5.4627E-32 50 954 45 6292
    gene expression 2.7894E-31 50 1283 48 6292
    nucleic acid metabolic process 2.5213E-24 50 1415 45 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.2221E-22 50 1566 45 6292
    cellular nitrogen compound metabolic process 4.7772E-20 50 1770 45 6292
    nitrogen compound metabolic process 7.9942E-20 50 1791 45 6292
    cellular macromolecule metabolic process 2.881E-19 50 2285 48 6292
    macromolecule metabolic process 1.0661E-18 50 2349 48 6292
    spliceosome assembly 2.7278E-15 50 18 9 6292
    primary metabolic process 2.0248E-14 50 2896 48 6292
    cellular metabolic process 1.7509E-13 50 3033 48 6292
    metabolic process 1.1288E-12 50 3157 48 6292
    ribonucleoprotein complex assembly 1.7261E-9 50 92 10 6292
    cellular process 2.1147E-8 50 4426 50 6292
    cellular macromolecular complex assembly 1.2054E-6 50 182 10 6292
    ribonucleoprotein complex biogenesis 4.4467E-6 50 374 13 6292
    mRNA splice site selection 9.2887E-6 50 6 3 6292
    cellular macromolecular complex subunit organization 2.8079E-5 50 259 10 6292
    macromolecular complex assembly 5.6456E-5 50 281 10 6292
    nuclear mRNA cis splicing, via spliceosome 1.8474E-4 50 3 2 6292
    macromolecular complex subunit organization 4.0691E-4 50 357 10 6292
    cellular component assembly 7.3898E-4 50 385 10 6292
    cellular component biogenesis 2.3512E-3 50 694 13 6292
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 3.2518E-3 50 11 2 6292
    translational initiation 4.3597E-3 50 42 3 6292
    nuclear mRNA 5'-splice site recognition 7.9466E-3 50 1 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA binding 5.209E-31 50 367 34 6292
    nucleic acid binding 1.1661E-27 50 666 38 6292
    binding 1.4631E-20 50 1294 41 6292
    mRNA binding 6.1287E-14 50 35 10 6292
    snRNA binding 4.6705E-6 50 5 3 6292
    translation factor activity, nucleic acid binding 3.7912E-4 50 44 4 6292
    translation initiation factor activity 1.2077E-3 50 27 3 6292
    pre-mRNA 5'-splice site binding 7.9466E-3 50 1 1 6292
    U2 snRNA binding 7.9466E-3 50 1 1 6292
    U1 snRNA binding 7.9466E-3 50 1 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle