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Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome. The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation. The cellular process by which a complex containing RNA and proteins is synthesized, aggregates, and bonds together. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: generation of catalytic spliceosome for first transesterification step
Acc: GO:0000349
Aspect: Biological Process
Desc: Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome.
Synonyms:
  • catalytic spliceosome assembly for first transesterification step
  • spliceosomal C1 complex biosynthesis
  • spliceosomal A2-2 complex biosynthesis
  • U12-type catalytic spliceosome formation for first transesterification step
  • formation of catalytic spliceosome for first transesterification step
  • spliceosomal C1 complex formation
  • U2-type catalytic spliceosome formation for first transesterification step
  • GO:0000357
  • GO:0000356
  • spliceosomal A2-2 complex formation
Proteins in PDR annotated with:
   This term: 10 [Search]
   Term or descendants: 10 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000349 - generation of catalytic spliceosome for first transesterification step (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle