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A protein complex found in the cytoplasm that binds the 5' cap structure of an mRNA, and typically consists of the cap-binding protein eIF4E, the adaptor protein eIF4G, and a multi-factor complex comprising eIF1, eIF2, eIF3 and eIF5. This complex mediates recruitment of the 40S subunit to mRNA. Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA. A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together. Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA. A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: RNA cap binding complex
Acc: GO:0034518
Aspect: Cellular Component
Desc: Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA.
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 34 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0034518 - RNA cap binding complex (interactive image map)

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