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Protein Overview: HOT1

General Information:
Name(s) found: HOT1 / YMR172W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 719 amino acids

    Gene Ontology:
    Cellular Component: nuclear chromosome [IDALink to PubMed article]
    Biological Process: hyperosmotic response [IGILink to PubMed article][IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [TASLink to PubMed article]
    Molecular Function: specific RNA polymerase II transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGMGIAILC IVRTKIYRIT ISFDYSTLMS PFFLFLMMPT TLKDGYRMNS QVNEDAIGIN  60
   61 LDLSLPTHIS PTTGSESASG SNASTLRNDG NALDGGLLRT SAAISAPTGT SQPTETIGEK 120
  121 LSNEERVNSN VSASNSTTAG TGRMLSQSLT NDSPSNEIST DQLKIFQRMD EMSARMIEME 180
  181 ESFNKLSNKI AEQNTMVLNL KQDNYKVMNK LNILLKLVAQ PSARPSTNNA QNKLAIELLN 240
  241 SISAVSSAYL QKMQNNGSGR QHTADLCTGD SNTHSGINQH RTTNGTIDVN TNTAQLNNQF 300
  301 SNALNTILPD QQHNRNNVSQ NINQSLPNRQ LGPVINTQAN QNQSQVLIHN TNTHQQVNRS 360
  361 PISFPNASTD KPFKLNPNGI KRRRRNTQSN NNASTNDHAS AAQKPISALS PLTNSHNSTT 420
  421 SMNYTNSSIH SGVTSASNSF HDLNSLNNFG TTTALSLPSL ALDNASFPPN QNVIPPIINN 480
  481 TQQPLSFSQL INQDSTTSEL LPSGKSGVNT NIVNRNRAST LPSYPKPMTV KSNVDDDGYQ 540
  541 EDDDDDGDDE GDGRDNEEDS TAEEDEVDDE IETDMKNASI NKRRRSLHHK KSNSLNGRRK 600
  601 LHGESATKPN INSDLHYRIL KAPTDVKTIW EEYDTGIRGK PSIKHLEAKY GNKWRLNKNK 660
  661 KTFSRRKRLY KFILNGMERG KTAQEMIETL ENKRLYKDDE DGEVKKRTIG WLQESLAGI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CKA1 CKA2 CKB1 CKB2 HOT1
    View Details Krogan NJ, et al. (2006) CAB3 CHD1 CKA1 CKA2 CKB1 CKB2 ELF1 HOT1 MSC3 NRG1 PGA2 REH1 RIM13 VHS3 YLR407W
    View Details Gavin AC, et al. (2002) CAB3 CHD1 CKA1 CKA2 CKB1 CKB2 HHF1, HHF2 HOT1 ISW1 ISW2 NIP1 PRT1 RET1 RPG1 RVB2 SPT16 SSA4 TIF35 UTP22 VPS1 YTA7
    View Details Ho Y, et al. (2002) CIC1 CKA1 CKA2 CKB1 CKB2 DBP10 DBP2 EGD1 ENP2 ERB1 FPR3 GDE1 HAS1 HHF1, HHF2 HHT1, HHT2 HOT1 HTA1 HTB2 KRE33 KRI1 MGM101 MRPL1 NOC3 NOG1 NOP12 NOP2 NOP4 NOP56 NOP7 NUG1 PDI1 POB3 POL2 PUF6 PWP1 RRP14 RRP5 SFP1 SPT16 SSF1 TIF4631 TIF6 TRL1 UTP22 VMR1 VPS73 WTM2 YER084W YRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HOT1 and NOP56 Huh WK, et al. (2003)
    View Data HOT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..154] deduced N/A No confident structure predictions are available.
    2 View Details [155..588] ab initio 9.25 No description for 1i3qA was found.
    3 View Details [589..719] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle