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Protein Overview: VAC14

General Information:
Name(s) found: VAC14 / YLR386W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 880 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole membrane [IDALink to PubMed article]
    vacuole [IDALink to PubMed article]
    Biological Process: vacuole inheritance [IMPLink to PubMed article]
    phospholipid metabolic process [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: enzyme activator activity [IMPLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKSIAKGLS DKLYEKRKAA ALELEKLVKQ CVLEGDYDRI DKIIDELCRD YAYALHQPMA  60
   61 RNAGLMGLAA TAIALGINDV GRYLRNILPP VLACFGDQND QVRFYACESL YNIAKIAKGE 120
  121 ILVYFNEIFD VLCKISADTE NSVRGAAELL DRLIKDIVAE RASNYISIVN NGSHGLLPAI 180
  181 KTDPISGDVY QEEYEQDNQL AFSLPKFIPL LTERIYAINP DTRVFLVDWL KVLLNTPGLE 240
  241 LISYLPSFLG GLFTFLGDSH KDVRTVTHTL MDSLLHEVDR ISKLQTEIKM KRLERLKMLE 300
  301 DKYNNSSTPT KKADGALIAE KKKTLMTALG GLSKPLSMET DDTKLSNTNE TDDERHLTSQ 360
  361 EQLLDSEATS QEPLRDGEEY IPGQDINLNF PEVITVLVNN LASSEAEIQL IALHWIQVIL 420
  421 SISPNVFIPF LSKILSVLLK LLSDSDPHIT EIAQLVNGQL LSLCSSYVGK ETDGKIAYGP 480
  481 IVNSLTLQFF DSRIDAKIAC LDWLILIYHK APNQILKHND SMFLTLLKSL SNRDSVLIEK 540
  541 ALSLLQSLCS DSNDNYLRQF LQDLLTLFKR DTKLVKTRAN FIMRQISSRL SPERVYKVIS 600
  601 SILDNYNDTT FVKMMIQILS TNLITSPEMS SLRNKLRTCE DGMFFNSLFK SWCPNPVSVI 660
  661 SLCFVAENYE LAYTVLQTYA NYELKLNDLV QLDILIQLFE SPVFTRMRLQ LLEQQKHPFL 720
  721 HKCLFGILMI IPQSKAFETL NRRLNSLNIW TSQSYVMNNY IRQRENSNFC DSNSDISQRS 780
  781 VSQSKLHFQE LINHFKAVSE EDEYSSDMIR LDHGANNKSL LLGSFLDGID EDKQEIVTPI 840
  841 SPMNEAINEE MESPNDNSSV ILKDSGSLPF NRNVSDKLKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FIG4 VAC14
    View Details Krogan NJ, et al. (2006) FIG4 KRE5 OAF1 VAC14
    View Details Gavin AC, et al. (2006) MEC1 SEN54 VAC14
    View Details Gavin AC, et al. (2002) ACC1 CCT5 CLU1 CRN1 ECM29 KAP123 MEC1 MIP6 MIS1 MRPL23 NAB3 NAB6 NRD1 ROM2 RPA135 SEN54 SIT4 SUI3 SUP35 SUP45 TAO3 USO1 UTP20 VAC14 VPS5 YJL017W
    View Details Ho Y, et al. (2002) BFR2 BIR1 BNA5 CDC7 COR1 DOG1 ECM10 ENP1 FET4 FPR3 HAS1 JIP3 MAM33 NUT1 PDC5 PDC6 PIM1 PRP8 PST2 QCR2 RPC19 SAP185 SAP190 SAR1 SEC27 SIT4 SNP1 SRP1 STI1 THI3 TPS1 UBI4 VAC14

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD51 VAC14 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VAC14 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..199] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [200..653] ORFEUS 11.67 Clathrin heavy chain proximal leg segment
    3 View Details [654..880] MSA 1.009959 View MSA. No confident structure predictions are available.
    4 View Details [787..880] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.53151481871847 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.70854853801477 bayes_pls_golite062009
  • protein binding
    		•  1.61131270705552 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.1879835276438 bayes_pls_golite062009
  • DNA binding
    		•  1.03880684185645 bayes_pls_golite062009
  • signal transducer activity
    		•  0.862740830365635 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.862740830365635 bayes_pls_golite062009
  • structural molecule activity
    		•  0.851103372489505 bayes_pls_golite062009
  • translation regulator activity
    		•  0.642878560112121 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.620348955429476 bayes_pls_golite062009
  • transcription factor activity
    		•  0.389120912139882 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.286790642914928 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.69

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle