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Protein Overview: VMA5

General Information:
Name(s) found: VMA5 / YKL080W [SGD]
Description(s) found:
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  • gi|6322770|ref|NP_012843.1| Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membr [NCBI NR]
  • gi|56966213|pdb|1U7L|A Chain A, Crystal Structure Of Subunit C (Vma5p) Of The Yeast V-Atpase [NCBI NR]
  • gi|549206|sp|P31412.4|VATC_YEAST RecName: Full=V-type proton ATPase subunit C; Short=V-ATPase subunit C; AltName: Full=Vacuolar proton pump subunit C; AltName: Full=V-ATPase 42 kDa subunit [NCBI NR]
  • pir||S37905 H+-exporting ATPase (EC 3.6.3.6) chain C, vacuolar - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|486116|emb|CAA81917.1| VMA5 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|414714|emb|CAA53237.1| vacuolar ATPase subunit C [Saccharomyces cerevisiae] [NCBI NR]
  • V-type proton ATPase subunit C OS=Saccharomyces cerevisiae GN=VMA5 PE=1 SV=4 [Swiss-Prot]
  • VMA5 H+-ATPase V1 domain 42 KD subunit, vacuolar [mips]
  • Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane [SGD]
  • VMA5, Chr XI from 284672-285850 [yeast_orfs2]
  • Chr XI from 284672-285850 [yeastorf3.fasta]
  • Chr XI from 284671-285849 [yeastorf4.fasta]
  • (P31412) Vacuolar ATP synthase subunit C (EC 3.6.3.14) (V-ATPase C subunit) (Vacuolar proton pump C subunit) (V-ATPase 42 kDa subunit) [4932.FASTACCERV.txt]
  • VMA5 SGDID:S0001563, Chr XI from 284675-285853, Verified ORF [yeastflysequest.fasta]
  • Vacuolar H+ ATPase subunit C of the catalytic (V1) sector [Saccharomyces cerevisiae]gi|414714|emb|CAA53237.1| vacuolar ATPase subunit C [Saccharomyces cerevisiae]gi|486116|emb|CAA81917.1| VMA5 [Saccharomyces cerevisiae]gi|549206|sp|P31412|VATC_YEAST Va [nrdb_11152004_Chlamydomonas]
  • VMA5 SGDID:S000001563, Chr XI from 284674-285852, Verified ORF, "Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domai [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • VMA5 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Vacuolar ATP synthase subunit C (V-ATPase C subunit) (Vacuolar proton pump C subunit) (V-ATPase 42 kDa subunit) [nr-271106-contam.fasta]
  • vacuolar ATPase subunit C [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; Vma5p [Saccharomyces ce [nr-271106-contam.fasta]
  • Chain A, Crystal Structure Of Subunit C (Vma5p) Of The Yeast V-Atpase [nr-271106-contam.fasta]
  • VMA5 SGDID:S000001563, Chr XI from 284674-285852, Verified ORF, "Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • V-type proton ATPase subunit C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VMA5 PE=1 SV=4 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • VMA5 SGDID:S000001563, Chr XI from 285030-286208, Genome Release 64-1-1, Verified ORF, "Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane" [yeast-030211-contam.fasta]
  • VMA5 SGDID:S000001563, Chr XI from 285030-286208, Genome Release 64-2-1, Verified ORF, "Subunit C of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits" [20141208_orf_trans.fasta]
  • TR8346|c0_g1_i1|g.5781 ORF TR8346|c0_g1_i1|g.5781 TR8346|c0_g1_i1|m.5781 type:complete len:393 (+) TR8346|c0_g1_i1:176-1354(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • TR21|c0_g1_i1|g.25 ORF TR21|c0_g1_i1|g.25 TR21|c0_g1_i1|m.25 type:complete len:393 (+) TR21|c0_g1_i1:926-2104(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta]
  • YKL080W SGDID:S000001563, Chr XI from 285030-286208, Genome Release 64-1-1, Verified ORF, "Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_6565|g.4940 ORF asmbl_6565|g.4940 asmbl_6565|m.4940 type:complete len:393 (+) asmbl_6565:2125-3303(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • ID=asmbl_6799|g.4133 ORF ID=asmbl_6799|g.4133 ID=asmbl_6799|m.4133 type:complete len:393 (+) ID=asmbl_6799:2125-3303(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
  • ID=asmbl_6754|g.4098 ORF ID=asmbl_6754|g.4098 ID=asmbl_6754|m.4098 type:complete len:393 (+) ID=asmbl_6754:176-1354(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 392 amino acids

    Gene Ontology:
    Cellular Component: vacuolar proton-transporting V-type ATPase, V1 domain [TASLink to PubMed articleLink to PubMed article]
    fungal-type vacuole membrane [TASLink to PubMed article]
    Biological Process: vacuolar acidification [TASLink to PubMed articleLink to PubMed article]
    Molecular Function: proton-transporting ATPase activity, rotational mechanism [TASLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATALYTAND FILISLPQNA QPVTAPGSKT DSWFNETLIG GRAFVSDFKI PEFKIGSLDT  60
   61 LIVESEELSK VDNQIGASIG KIIEILQGLN ETSTNAYRTL PINNMPVPEY LENFQWQTRK 120
  121 FKLDKSIKDL ITLISNESSQ LDADVRATYA NYNSAKTNLA AAERKKTGDL SVRSLHDIVK 180
  181 PEDFVLNSEH LTTVLVAVPK SLKSDFEKSY ETLSKNVVPA SASVIAEDAE YVLFNVHLFK 240
  241 KNVQEFTTAA REKKFIPREF NYSEELIDQL KKEHDSAASL EQSLRVQLVR LAKTAYVDVF 300
  301 INWFHIKALR VYVESVLRYG LPPHFNIKII AVPPKNLSKC KSELIDAFGF LGGNAFMKDK 360
  361 KGKINKQDTS LHQYASLVDT EYEPFVMYII NL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) VMA4 VMA5
    View Details (MIPS) Mewes HW, et al. (2004) CUP5 PPA1 STV1 TFP1 TFP3 VMA10 VMA13 VMA2 VMA4 VMA5 VMA6 VMA7 VMA8 VPH1
    View Details Krogan NJ, et al. (2006) CYB5 ETR1 NOT3 RPL40B, RPL40A VMA5 VPS1 YPT1
    View Details Gavin AC, et al. (2006) VMA13 VMA4 VMA5 VMA7 VMA8
    View Details Gavin AC, et al. (2002) RAV1 TFP1 VMA10 VMA13 VMA2 VMA4 VMA5 VMA6 VMA7 VMA8 VPH1
    View Details Ho Y, et al. (2002) AAT2 ACH1 ACO1 ADK1 AFR1 AHP1 ARC1 ARF1 ATP3 CAR2 CDC33 CLU1 COF1 COR1 CPR1 CYR1 CYS4 DUG2 EFB1 EGD1 ERG13 ERG6 FPR1 FRS2 GND1 GND2 GRX1 GUS1 HEF3 HHF1, HHF2 LRO1 LSP1 MET6 NTF2 OLA1 OYE2 PFK1 PIL1 PRM2 RNR2 RSN1 SAH1 SCP160 SEC53 SEN15 SES1 SNU13 SOD1 TEF4 TEM1 THS1 TIF1, TIF2 TMA19 TSA2 UBA1 VMA4 VMA5 WTM1 YHB1 YNK1
    View Details Qiu et al. (2008) CUP5 PPA1 STV1 TFP1 TFP3 VMA10 VMA13 VMA2 VMA4 VMA5 VMA6 VMA7 VMA8 VMA9 VPH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VMA5 Huh WK, et al. (2003)
    View Data VMA5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..392] Pfam 87.408935 V-ATPase subunit C No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrogen ion transmembrane transporter activity
    		•  12.3352255617459 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  10.5863459521035 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  9.47957751673845 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  8.04670314838796 bayes_pls_golite062009
  • hydrogen-exporting ATPase activity, phosphorylative mechanism
    		•  7.25165353297621 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  5.95289483482599 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  5.74889738890923 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.64669396672268 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  5.22844923180027 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  4.07961473146848 bayes_pls_golite062009
  • transporter activity
    		•  3.46526113720851 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.37048202892137 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.36986693191031 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
    		•  3.01531981010483 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.60440013485447 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.60069637398921 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.58215499145116 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57906484106374 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57862595121731 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50524643368579 bayes_pls_golite062009
  • hydrolase activity
    		•  2.11429056985835 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.96367406225153 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.76379885224229 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.69566510056354 bayes_pls_golite062009
  • ATPase activity
    		•  1.69439936736892 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.67811565012269 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.67577649087358 bayes_pls_golite062009
  • binding
    		•  1.5759873319504 bayes_pls_golite062009
  • catalytic activity
    		•  0.902495165806215 bayes_pls_golite062009
  • protein binding
    		•  0.458389541110755 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle