YRC Public Data Repository - Protein Structure Prediction

Protein:	VMA5
Organism:	Saccharomyces cerevisiae
Length:	392 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VMA5.

Description	E-value	Query Range	Subject Range
VATC_MANSE - V-type proton ATPase subunit C OS=Manduca sexta PE=2 SV=1	0.0	[9..392]	[2..378]
gi\|220953390, gi... - gi\|220953390\|gb\|ACL89238.1\| Vha44-PA [synthetic construct], gi\|220943182\|gb\|ACL84134.1\| Vha44-PA [sy... gi\|195334907, gi... - gi\|195334907\|ref\|XP_002034118.1\| GM20063 [Drosophila sechellia], gi\|194126088\|gb\|EDW48131.1\| GM20063... gi\|195583914, gi... - gi\|195583914\|ref\|XP_002081761.1\| GD25545 [Drosophila simulans], gi\|194193770\|gb\|EDX07346.1\| GD25545 ... Vha44-PA, Vha44-PB - The gene Vacuolar H<sup>+</sup> ATPase 44kD C subunit is referred to in FlyBase by the symbol Dmel\V...	0.0	[9..392]	[3..380]
gi\|109087159 - gi\|109087159\|ref\|XP_001084086.1\| PREDICTED: ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 ... gi\|190691657, gi... - gi\|190691657\|gb\|ACE87603.1\| ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 protein [synthet... VATC1_PONAB - V-type proton ATPase subunit C 1 OS=Pongo abelii GN=ATP6V1C1 PE=2 SV=1 gi\|55726675 - gi\|55726675\|emb\|CAH90100.1\| hypothetical protein [Pongo abelii] CCDS6296.1_1 - null VATC1_MACFA - V-type proton ATPase subunit C 1 OS=Macaca fascicularis GN=ATP6V1C1 PE=2 SV=1 gi\|114621191, gi... - gi\|114621193\|ref\|XP_001155379.1\| PREDICTED: ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 ... ATP6V1C1 - ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1	0.0	[9..391]	[2..375]
gi\|1213460 - gi\|1213460\|gb\|AAB51350.1\| C subunit of V-ATPase	0.0	[9..392]	[1..373]
VATC1_MOUSE - V-type proton ATPase subunit C 1 OS=Mus musculus GN=Atp6v1c1 PE=1 SV=4	0.0	[9..391]	[2..375]
VATC1_BOVIN - V-type proton ATPase subunit C 1 OS=Bos taurus GN=ATP6V1C1 PE=1 SV=3	0.0	[9..391]	[2..375]

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Predicted Domain #1

Region A:
Residues: [1-392]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATALYTAND FILISLPQNA QPVTAPGSKT DSWFNETLIG GRAFVSDFKI PEFKIGSLDT  60
   61 LIVESEELSK VDNQIGASIG KIIEILQGLN ETSTNAYRTL PINNMPVPEY LENFQWQTRK 120
  121 FKLDKSIKDL ITLISNESSQ LDADVRATYA NYNSAKTNLA AAERKKTGDL SVRSLHDIVK 180
  181 PEDFVLNSEH LTTVLVAVPK SLKSDFEKSY ETLSKNVVPA SASVIAEDAE YVLFNVHLFK 240
  241 KNVQEFTTAA REKKFIPREF NYSEELIDQL KKEHDSAASL EQSLRVQLVR LAKTAYVDVF 300
  301 INWFHIKALR VYVESVLRYG LPPHFNIKII AVPPKNLSKC KSELIDAFGF LGGNAFMKDK 360
  361 KGKINKQDTS LHQYASLVDT EYEPFVMYII NL

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	87.408935
Match:	PF03223
Description:	V-ATPase subunit C

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
hydrogen ion transmembrane transporter activity	12.3352255617459	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	10.5863459521035	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	9.47957751673845	bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism	8.04670314838796	bayes_pls_golite062009
hydrogen-exporting ATPase activity, phosphorylative mechanism	7.25165353297621	bayes_pls_golite062009
cation-transporting ATPase activity	5.95289483482599	bayes_pls_golite062009
cation transmembrane transporter activity	5.74889738890923	bayes_pls_golite062009
ion transmembrane transporter activity	5.64669396672268	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	5.22844923180027	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	4.07961473146848	bayes_pls_golite062009
transporter activity	3.46526113720851	bayes_pls_golite062009
transmembrane transporter activity	3.37048202892137	bayes_pls_golite062009
substrate-specific transporter activity	3.36986693191031	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	3.01531981010483	bayes_pls_golite062009
primary active transmembrane transporter activity	2.60440013485447	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.60069637398921	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.58215499145116	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.57906484106374	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.57862595121731	bayes_pls_golite062009
active transmembrane transporter activity	2.50524643368579	bayes_pls_golite062009
hydrolase activity	2.11429056985835	bayes_pls_golite062009
ATPase activity, coupled	1.96367406225153	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.76379885224229	bayes_pls_golite062009
pyrophosphatase activity	1.69566510056354	bayes_pls_golite062009
ATPase activity	1.69439936736892	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.67811565012269	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.67577649087358	bayes_pls_golite062009
binding	1.5759873319504	bayes_pls_golite062009
catalytic activity	0.902495165806215	bayes_pls_golite062009
protein binding	0.458389541110755	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: