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Protein Overview: Vha44-PA, Vha44-PB

General Information:
Name(s) found: Vha44-PB / FBpp0086320 [FlyBase]
Vha44-PA / FBpp0086317 [FlyBase]
Description(s) found:
Found 36 descriptions.
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  • The gene Vacuolar H<sup>+</sup> ATPase 44kD C subunit is referred to in FlyBase by the symbol Dmel\Vha44 (CG8048, FBgn0020611). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12212318..12224142. It has the cytological map location 53B5-53C1. Based on sequence similarity, it is predicted to have molecular function</span>: hydrogen-exporting ATPase activity, phosphorylative mechanism. Based on sequence similarity, it is predicted to be involved in the biological process</span>: proton transport. 10 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
  • The gene Vacuolar H<sup>+</sup> ATPase 44kD C subunit is referred to in FlyBase by the symbol Dmel\Vha44 (CG8048, FBgn0020611). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12212318..12224142. It has the cytological map location 53B5-53C1. Based on sequence similarity, it is predicted to have molecular function</span>: hydrogen-exporting ATPase activity, phosphorylative mechanism. Based on sequence similarity, it is predicted to be involved in the biological process</span>: proton transport. 10 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 388 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSEYWIISA PGDKTCQQTY DTMNNLTSKQ HNLCNNYKFH IPDLKVGTLD QLVGLSDDLG  60
   61 KLDTYVEQIT RKVANYLGEV LEDQRDKLHE NLMANNTELP QYLTRFQWDM AKYPIKQSLR 120
  121 NIADIISKQI GQIDGDLKTK SQAYNNLKGN LQNLEKKKTG SLLTRNLADL VKKEHFILDS 180
  181 EYLTTLLVIV PKVMANDWLT NYEKITDMIV PRSSQLIQED ADYCLFNVTL FKKVAEEFKL 240
  241 HARERKFIVR DFVYNEEELA AGKNEMTKLM TDKKKQFGPL VRWLKVNFSE AFCALIHVKA 300
  301 LRVFVESVLR YGLPVNFQAI LIEPNKKSVK RLRDVLNQLY GHLDGASAGG AVSSADNVDI 360
  361 PGLGFGQSEY FPYVFYKVNI DMVEQAKV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..388] PSI-BLAST 127.0 Crystal Structure of subunit C (vma5p) of the yeast V-ATPase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrogen ion transmembrane transporter activity
    		•  12.3352255617459 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  10.5863459521035 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  9.47957751673845 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  8.04670314838796 bayes_pls_golite062009
  • hydrogen-exporting ATPase activity, phosphorylative mechanism
    		•  7.25165353297621 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  5.95289483482599 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  5.74889738890923 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.64669396672268 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  5.22844923180027 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  4.07961473146848 bayes_pls_golite062009
  • transporter activity
    		•  3.46526113720851 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.37048202892137 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.36986693191031 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
    		•  3.01531981010483 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.60440013485447 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.60069637398921 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.58215499145116 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57906484106374 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57862595121731 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50524643368579 bayes_pls_golite062009
  • hydrolase activity
    		•  2.11429056985835 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.96367406225153 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.76379885224229 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.69566510056354 bayes_pls_golite062009
  • ATPase activity
    		•  1.69439936736892 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.67811565012269 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.67577649087358 bayes_pls_golite062009
  • binding
    		•  1.5759873319504 bayes_pls_golite062009
  • catalytic activity
    		•  0.902495165806215 bayes_pls_golite062009
  • protein binding
    		•  0.458389541110755 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle