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Protein Overview: ETR1

General Information:
Name(s) found: ETR1 / YBR026C [SGD]
Description(s) found:
Found 32 descriptions.
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  • 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 380 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: fatty acid biosynthetic process [IMPLink to PubMed article]
    aerobic respiration [IMPLink to PubMed article]
    Molecular Function: enoyl-[acyl-carrier-protein] reductase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPTFKRYMS SSAHQIPKHF KSLIYSTHEV EDCTKVLSVK NYTPKQDLSQ SIVLKTLAFP  60
   61 INPSDINQLQ GVYPSRPEKT YDYSTDEPAA IAGNEGVFEV VSLPSGSSKG DLKLGDRVIP 120
  121 LQANQGTWSN YRVFSSSSDL IKVNDLDLFS AATVSVNGCT GFQLVSDYID WNSNGNEWII 180
  181 QNAGTSSVSK IVTQVAKAKG IKTLSVIRDR DNFDEVAKVL EDKYGATKVI SESQNNDKTF 240
  241 AKEVLSKILG ENARVRLALN SVGGKSSASI ARKLENNALM LTYGGMSKQP VTLPTSLHIF 300
  301 KGLTSKGYWV TEKNKKNPQS KIDTISDFIK MYNYGHIISP RDEIETLTWN TNTTTDEQLL 360
  361 ELVKKGITGK GKKKMVVLEW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CYB5 ETR1 NOT3 RPL40B, RPL40A VMA5 VPS1 YPT1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CAB4 No Comments Hazbun TR, et al. (2003)
    View Run NOP9 No Comments Hazbun TR, et al. (2003)
    View Run RBA50 No Comments Hazbun TR, et al. (2003)
    View Run TIM50 No Comments Hazbun TR, et al. (2003)
    View Run CWC25 No Comments Hazbun TR, et al. (2003)
    View Run RIX7 No Comments Hazbun TR, et al. (2003)
    View Run CLB2 No Comments McCusker D, et al (2007)
    View Run ASF1 3906: TAP-tagged Green EM, et al (2005)
    View Run ASF1 3908: TAP-tagged, includes hir2(delta) in background Green EM, et al (2005)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ETR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155]
    [340..380]    		 PSI-BLAST 112.154902 Quinone oxidoreductase
    2 View Details [156..339] PSI-BLAST 112.154902 Quinone oxidoreductase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  1.23679054027553 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  0.62461633437589 bayes_pls_golite062009
  • 3-oxoacyl-[acyl-carrier-protein] reductase activity
    		•  0.604742541607263 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.527946013169731 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  0.33551402794014 bayes_pls_golite062009
  • malate dehydrogenase activity
    		•  0.29197621064275 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  0.233238483713519 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.19685680097448 bayes_pls_golite062009
  • chaperone binding
    		•  0.165316141886854 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.100470710829263 bayes_pls_golite062009
  • DNA binding
    		•  0.0870043837215047 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  0.00644214957417527 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle