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Protein Overview: CSE1

General Information:
Name(s) found: CSE1 / YGL238W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 960 amino acids

    Gene Ontology:
    Cellular Component: nuclear envelope [IDALink to PubMed article]
    Biological Process: protein export from nucleus [IGILink to PubMed article][IPILink to PubMed article]
    Molecular Function: importin-alpha export receptor activity [IGILink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDLETVAKF LAESVIASTA KTSERNLRQL ETQDGFGLTL LHVIASTNLP LSTRLAGALF  60
   61 FKNFIKRKWV DENGNHLLPA NNVELIKKEI VPLMISLPNN LQVQIGEAIS SIADSDFPDR 120
  121 WPTLLSDLAS RLSNDDMVTN KGVLTVAHSI FKRWRPLFRS DELFLEIKLV LDVFTAPFLN 180
  181 LLKTVDEQIT ANENNKASLN ILFDVLLVLI KLYYDFNCQD IPEFFEDNIQ VGMGIFHKYL 240
  241 SYSNPLLEDP DETEHASVLI KVKSSIQELV QLYTTRYEDV FGPMINEFIQ ITWNLLTSIS 300
  301 NQPKYDILVS KSLSFLTAVT RIPKYFEIFN NESAMNNITE QIILPNVTLR EEDVELFEDD 360
  361 PIEYIRRDLE GSDTDTRRRA CTDFLKELKE KNEVLVTNIF LAHMKGFVDQ YMSDPSKNWK 420
  421 FKDLYIYLFT ALAINGNITN AGVSSTNNLL NVVDFFTKEI APDLTSNNIP HIILRVDAIK 480
  481 YIYTFRNQLT KAQLIELMPI LATFLQTDEY VVYTYAAITI EKILTIRESN TSPAFIFHKE 540
  541 DISNSTEILL KNLIALILKH GSSPEKLAEN EFLMRSIFRV LQTSEDSIQP LFPQLLAQFI 600
  601 EIVTIMAKNP SNPRFTHYTF ESIGAILNYT QRQNLPLLVD SMMPTFLTVF SEDIQEFIPY 660
  661 VFQIIAFVVE QSATIPESIK PLAQPLLAPN VWELKGNIPA VTRLLKSFIK TDSSIFPDLV 720
  721 PVLGIFQRLI ASKAYEVHGF DLLEHIMLLI DMNRLRPYIK QIAVLLLQRL QNSKTERYVK 780
  781 KLTVFFGLIS NKLGSDFLIH FIDEVQDGLF QQIWGNFIIT TLPTIGNLLD RKIALIGVLN 840
  841 MVINGQFFQS KYPTLISSTM NSIIETASSQ SIANLKNDYV DLDNLEEIST FGSHFSKLVS 900
  901 ISEKPFDPLP EIDVNNGVRL YVAEALNKYN AISGNTFLNT ILPQLTQENQ VKLNQLLVGN 960
  961

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CSE1 MIR1
    View Details Krogan NJ, et al. (2006) AAR2 BRR1 BRR2 CSE1 LUC7 MUD1 NAM8 PRP2 PRP3 PRP31 PRP39 PRP40 PRP42 PRP6 PRP8 RRG7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNU114 SNU56 SNU66 SNU71 TAD2 YDL085C-A YHC1 YJU2 YNL092W
    View Details Gavin AC, et al. (2006) ADE3 CSE1 SEC7 TDH1 TOM1 YDR341C
    View Details Gavin AC, et al. (2002) ADH1 CCT4 CSE1 DHH1 DUG1 ECM29 FKS1 GCN1 GCN20 GFA1 IDH2 KAP123 KTR3 MIR1 RGR1 SAM1 SEC7 SLC1 SRV2 YHR020W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MLC1 CSE1 1 Unpublished Fields Lab Data
    View Screen GPA1 CSE1 1 Unpublished Fields Lab Data
    View Screen UBC7 CSE1 1 Unpublished Fields Lab Data
    View Screen PRM3 CSE1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CSE1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..220] MSA 6.154993 View MSA. No confident structure predictions are available.
    2 View Details [221..811] MSA 18.235994 View MSA. No confident structure predictions are available.
    3 View Details [812..960] MSA 1.094981 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein transporter activity
    		•  4.58709163830613 bayes_pls_golite062009
  • nuclear export signal receptor activity
    		•  3.48172991171337 bayes_pls_golite062009
  • binding
    		•  3.0667965351474 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  2.74547353635661 bayes_pls_golite062009
  • transporter activity
    		•  2.48700774379895 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.34284977509828 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.26725422172281 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  1.91487015967262 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.76231475025891 bayes_pls_golite062009
  • protein binding
    		•  1.73688475473996 bayes_pls_golite062009
  • DNA binding
    		•  1.62032607987786 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.51103985174196 bayes_pls_golite062009
  • signal transducer activity
    		•  1.51103985174196 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.28481004323799 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.09652988954158 bayes_pls_golite062009
  • transcription factor activity
    		•  0.923253759652909 bayes_pls_golite062009
  • structural molecule activity
    		•  0.908029258648777 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.83079633551839 bayes_pls_golite062009
  • translation regulator activity
    		•  0.82193201542158 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.803700928110921 bayes_pls_golite062009
  • clathrin binding
    		•  0.70539170437469 bayes_pls_golite062009
  • signal sequence binding
    		•  0.57106697498903 bayes_pls_golite062009
  • mRNA binding
    		•  0.46864854653143 bayes_pls_golite062009
  • RNA binding
    		•  0.40024158562931 bayes_pls_golite062009
  • importin-alpha export receptor activity
    		•  0.259676026705859 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252495966234234 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.248585912061178 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.226380819487924 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.217517113570989 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.178770060806735 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.175241020572885 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.174922130116569 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.100181463251306 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0635404099346928 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0548082069333885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.052195223119721 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0405268469927988 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0232727461674547 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle