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View Structure Prediction Details

Protein: CSE1
Organism: Saccharomyces cerevisiae
Length: 960 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CSE1.

Description E-value Query
Range
Subject
Range
XPO2_MOUSE - Exportin-2 OS=Mus musculus GN=Cse1l PE=1 SV=1
0.0 [2..957] [6..971]
gi|3560557 - gi|3560557|gb|AAC35008.1| cellular apoptosis susceptibility protein [Homo sapiens]
0.0 [2..957] [6..971]
CSE1 - Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of meta...
gi|207345565 - gi|207345565|gb|EDZ72341.1| YGL238Wp-like protein [Saccharomyces cerevisiae AWRI1631]
CSE1_YEAST - Importin alpha re-exporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CSE1 PE=1 SV=...
gi|151943580 - gi|151943580|gb|EDN61890.1| chromosome segregation-related protein [Saccharomyces cerevisiae YJM789]
gi|190407172 - gi|190407172|gb|EDV10439.1| importin alpha re-exporter [Saccharomyces cerevisiae RM11-1a]
0.0 [1..960] [1..960]
XPO2_PAGMA - Exportin-2 OS=Pagrus major GN=cse1l PE=2 SV=1
0.0 [2..957] [6..971]
gi|4837636 - gi|4837636|emb|CAB42967.1| CAS protein [Drosophila melanogaster]
0.0 [2..951] [6..962]
XPO2_ARATH - Exportin-2 OS=Arabidopsis thaliana GN=CAS PE=2 SV=1
0.0 [7..956] [11..963]
CSE1_SCHPO - Importin-alpha re-exporter OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=kap109 PE=3 SV=...
kap109 - karyopherin Kap109
0.0 [4..953] [1..960]
gi|34904406, gi|... - gi|7339699|dbj|BAA92904.1| putative importin-alpha re-exporter [Oryza sativa Japonica Group], gi|349...
0.0 [4..956] [8..974]

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Predicted Domain #1
Region A:
Residues: [1-220]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDLETVAKF LAESVIASTA KTSERNLRQL ETQDGFGLTL LHVIASTNLP LSTRLAGALF  60
   61 FKNFIKRKWV DENGNHLLPA NNVELIKKEI VPLMISLPNN LQVQIGEAIS SIADSDFPDR 120
  121 WPTLLSDLAS RLSNDDMVTN KGVLTVAHSI FKRWRPLFRS DELFLEIKLV LDVFTAPFLN 180
  181 LLKTVDEQIT ANENNKASLN ILFDVLLVLI KLYYDFNCQD 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
protein transporter activity 4.58709163830613 bayes_pls_golite062009
nuclear export signal receptor activity 3.48172991171337 bayes_pls_golite062009
binding 3.0667965351474 bayes_pls_golite062009
protein transmembrane transporter activity 2.74547353635661 bayes_pls_golite062009
transporter activity 2.48700774379895 bayes_pls_golite062009
nucleic acid binding 2.34284977509828 bayes_pls_golite062009
substrate-specific transporter activity 2.26725422172281 bayes_pls_golite062009
nuclear localization sequence binding 1.91487015967262 bayes_pls_golite062009
transcription regulator activity 1.76231475025891 bayes_pls_golite062009
protein binding 1.73688475473996 bayes_pls_golite062009
DNA binding 1.62032607987786 bayes_pls_golite062009
molecular transducer activity 1.51103985174196 bayes_pls_golite062009
signal transducer activity 1.51103985174196 bayes_pls_golite062009
transmembrane transporter activity 1.28481004323799 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.09652988954158 bayes_pls_golite062009
transcription factor activity 0.923253759652909 bayes_pls_golite062009
structural molecule activity 0.908029258648777 bayes_pls_golite062009
translation initiation factor activity 0.83079633551839 bayes_pls_golite062009
translation regulator activity 0.82193201542158 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.803700928110921 bayes_pls_golite062009
clathrin binding 0.70539170437469 bayes_pls_golite062009
signal sequence binding 0.57106697498903 bayes_pls_golite062009
mRNA binding 0.46864854653143 bayes_pls_golite062009
RNA binding 0.40024158562931 bayes_pls_golite062009
importin-alpha export receptor activity 0.259676026705859 bayes_pls_golite062009
active transmembrane transporter activity 0.252495966234234 bayes_pls_golite062009
ion transmembrane transporter activity 0.248585912061178 bayes_pls_golite062009
primary active transmembrane transporter activity 0.226380819487924 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.217517113570989 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.178770060806735 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.175241020572885 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.174922130116569 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.100181463251306 bayes_pls_golite062009
pyrophosphatase activity 0.0635404099346928 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0548082069333885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.052195223119721 bayes_pls_golite062009
cation transmembrane transporter activity 0.0405268469927988 bayes_pls_golite062009
transcription activator activity 0.0232727461674547 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [221-811]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPEFFEDNIQ VGMGIFHKYL SYSNPLLEDP DETEHASVLI KVKSSIQELV QLYTTRYEDV  60
   61 FGPMINEFIQ ITWNLLTSIS NQPKYDILVS KSLSFLTAVT RIPKYFEIFN NESAMNNITE 120
  121 QIILPNVTLR EEDVELFEDD PIEYIRRDLE GSDTDTRRRA CTDFLKELKE KNEVLVTNIF 180
  181 LAHMKGFVDQ YMSDPSKNWK FKDLYIYLFT ALAINGNITN AGVSSTNNLL NVVDFFTKEI 240
  241 APDLTSNNIP HIILRVDAIK YIYTFRNQLT KAQLIELMPI LATFLQTDEY VVYTYAAITI 300
  301 EKILTIRESN TSPAFIFHKE DISNSTEILL KNLIALILKH GSSPEKLAEN EFLMRSIFRV 360
  361 LQTSEDSIQP LFPQLLAQFI EIVTIMAKNP SNPRFTHYTF ESIGAILNYT QRQNLPLLVD 420
  421 SMMPTFLTVF SEDIQEFIPY VFQIIAFVVE QSATIPESIK PLAQPLLAPN VWELKGNIPA 480
  481 VTRLLKSFIK TDSSIFPDLV PVLGIFQRLI ASKAYEVHGF DLLEHIMLLI DMNRLRPYIK 540
  541 QIAVLLLQRL QNSKTERYVK KLTVFFGLIS NKLGSDFLIH FIDEVQDGLF Q

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [812-960]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QIWGNFIITT LPTIGNLLDR KIALIGVLNM VINGQFFQSK YPTLISSTMN SIIETASSQS  60
   61 IANLKNDYVD LDNLEEISTF GSHFSKLVSI SEKPFDPLPE IDVNNGVRLY VAEALNKYNA 120
  121 ISGNTFLNTI LPQLTQENQV KLNQLLVGN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle