Protein Overview: HAT2

General Information:
Name(s) found:	HAT2 / YEL056W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731418\|sp\|P39984.1\|HAT2_YEAST RecName: Full=Histone acetyltransferase type B subunit 2 [NCBI NR] gi\|6320779\|ref\|NP_010858.1\| Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silen [NCBI NR] gi\|603262\|gb\|AAB65031.1\| Hat2p: subunit of a cytoplasmic histone acetyltransferase [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S50533 hypothetical protein YEL056w - yeast (Saccharomyces cerevisiae) [NCBI NR] Histone acetyltransferase type B subunit 2 OS=Saccharomyces cerevisiae GN=HAT2 PE=1 SV=1 [Swiss-Prot] HAT2 Subunit of the major yeast histone acetyltransferase [mips] Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing [SGD] HAT2, Chr V from 47168-48373 [yeast_orfs2] Chr V from 47168-48373 [yeastorf3.fasta] (P39984) Histone acetyltransferase type B subunit 2 [4932.FASTACCERV.txt] HAT2 SGDID:S0000782, Chr V from 47168-48373, Verified ORF [yeastflysequest.fasta] Hat2p [Saccharomyces cerevisiae]gi\|731418\|sp\|P39984\|HAT2_YEAST Histone acetyltransferase type B subunit 2gi\|603262\|gb\|AAB65031.1\| Hat2p: subunit of a cytoplasmic histone acetyltransferase [Saccharomyces cerevisiae]gi\|1077611\|pir\|\|S50533 hypothetical pr [nrdb_11152004_Chlamydomonas] (P39984) Histone acetyltransferase type B subunit 2 (EC 2.3.1.48) [cerv4932.FASTAC] HAT2 SGDID:S000000782, Chr V from 47168-48373, Verified ORF, "Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Hat2p: subunit of a cytoplasmic histone acetyltransferase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing; Hat2p [Saccharomyces c [nr-271106-contam.fasta] Histone acetyltransferase type B subunit 2 [nr-271106-contam.fasta] HAT2 SGDID:S000000782, Chr V from 47168-48373, Verified ORF, "Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Histone acetyltransferase type B subunit 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HAT2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] HAT2 SGDID:S000000782, Chr V from 47168-48373, Genome Release 64-1-1, Verified ORF, "Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing" [yeast-030211-contam.fasta] HAT2 SGDID:S000000782, Chr V from 47168-48373, Genome Release 64-2-1, Verified ORF, "Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing" [20141208_orf_trans.fasta] TR8595\|c0_g1_i1\|g.5968 ORF TR8595\|c0_g1_i1\|g.5968 TR8595\|c0_g1_i1\|m.5968 type:complete len:402 (+) TR8595\|c0_g1_i1:71-1276(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR466\|c0_g1_i1\|g.363 ORF TR466\|c0_g1_i1\|g.363 TR466\|c0_g1_i1\|m.363 type:complete len:402 (+) TR466\|c0_g1_i1:80-1285(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YEL056W SGDID:S000000782, Chr V from 47168-48373, Genome Release 64-1-1, Verified ORF, "Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_6890\|g.5135 ORF asmbl_6890\|g.5135 asmbl_6890\|m.5135 type:complete len:402 (+) asmbl_6890:79-1284(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_7440\|g.4626 ORF ID=asmbl_7440\|g.4626 ID=asmbl_7440\|m.4626 type:complete len:402 (+) ID=asmbl_7440:70-1275(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_7134\|g.4258 ORF ID=asmbl_7134\|g.4258 ID=asmbl_7134\|m.4258 type:complete len:402 (+) ID=asmbl_7134:79-1284(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	401 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA ] cytoplasm [IDA ] histone acetyltransferase complex [IDA ][IPI ]
Biological Process:	chromatin assembly or disassembly [IDA] histone acetylation [IDA][IMP ] chromatin silencing at telomere [IGI]
Molecular Function:	histone binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENQEKPLSV DEEYDLWKSN VPLMYDFVSE TRLTWPSLTV QWLPTPVQEL DGGFIKQELI  60
   61 IGTHTSGEEE NYLKFAEINL PKEILSNEDP QEEAGEEYQS SLPAPRSNIR ITAKYEHEEE 120
  121 ITRARYMPQD PNIVATINGQ GTVFLYSRSE GLQSTLKFHK DNGYALSFST LVKGRLLSGS 180
  181 DDHTVALWEV GSGGDPTKPV RTWNDLHSDI INDNKWHNFN KDLFGTVSED SLLKINDVRA 240
  241 NNTTIDTVKC PQPFNTLAFS HHSSNLLAAA GMDSYVYLYD LRNMKEPLHH MSGHEDAVNN 300
  301 LEFSTHVDGV VVSSGSDNRL MMWDLKQIGA EQTPDDAEDG VPELIMVHAG HRSSVNDFDL 360
  361 NPQIPWLVAS AEEENILQVW KCSHSLPIVG GPPKVNKDII S

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ASF1 HAT1 HAT2 HHF1, HHF2 HHT1, HHT2 HIF1 MAM33 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POB3 PSH1 PTC4 RTT106 SPT16 YJR154W YKU70
View Details	(MIPS) Mewes HW, et al. (2004)		HAT1 HAT2
View Details	Krogan NJ, et al. (2006)		HAT1 HAT2 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 SWE1 YJR154W
View Details	Gavin AC, et al. (2006)		HAT1 HAT2 HHF1, HHF2 HIF1
View Details	Gavin AC, et al. (2002)		BDF2 CDC55 CKB1 DYN1 ECM5 GLY1 HAT1 HAT2 HHF1, HHF2 HIF1 HSM3 ICL1 IML1 KAP123 KRE33 LIP2 MAC1 MDN1 MIS1 MSB1 NIP1 NMD5 PFK1 PRO1 PRT1 PSD2 PSE1 PSH1 RPA135 RPC40 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT5 RPT6 RSC3 SAM1 TEL1 TSC11 USO1 UTP20 VTH2 YFR006W YPR077C
View Details	Ho Y, et al. (2002)		GND1 HAT1 HAT2 HIF1 RTN1
View Details	Qiu et al. (2008)		AHC1 HAT2 SAS3 YNG1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..401]	PSI-BLAST	71.39794	beta1-subunit of the signal-transducing G protein heterotrimer

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: HAT2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: