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Protein Overview: HMO1

General Information:
Name(s) found: HMO1 / YDR174W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 246 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nuclear chromatin [ISSLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    plasmid maintenance [IMPLink to PubMed article]
    Molecular Function: RNA polymerase I transcription factor activity [IDALink to PubMed article]
    single-stranded DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTDPSVKLK SAKDSLVSSL FELSKAANQT ASSIVDFYNA IGDDEEEKIE AFTTLTESLQ  60
   61 TLTSGVNHLH GISSELVNPI DDDKDAIIAA PVKAVRRKIE RDPNAPKKPL TVFFAYSAYV 120
  121 RQELREDRQK AGLPPLSSTE ITQEISKKWK ELSDNEKEKW KQAYNVELEN YQREKSKYLE 180
  181 AKKNGTLPPA SLENGPTHAP VPIPFSLQHA AEPPVEKRPH DDDGSSEKKK KKKKKDKKKD 240
  241 KSNSSI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) APP1 CST6 HMO1 MCM10 MIG1 SSA3 YRM1
    View Details Gavin AC, et al. (2002) ADH1 GIN4 HMO1 KCC4 PBP2 PDC1 PGI1 RAD1 RAD10 YEF3 YRA1
    View Details Ho Y, et al. (2002) ADH2 AIM21 BUD20 CBF5 CBP2 CCM1 CDC33 CIC1 COF1 CPR1 DBP7 EHD3 ENP2 FHL1 GBP2 GCN3 GPI15 HAS1 HHF1, HHF2 HMO1 HTA1 HTB1 HTB2 HYP2 IMD1 IMD3 ISA1 KRE33 KRI1 LSM2 MAM33 MDH1 MGM101 MRPS16 MSS116 NOC2 NOP12 NOP6 NPL3 OYE2 PET127 POL5 PRP43 PUF6 PWP1 RLI1 RLP24 RRP12 RRP5 TEF4 TIF4631 TRA1 TSR1 URB1 URB2 UTP10 UTP20 YFL006W YPP1 YRA1 YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YJL147C HMO1 2 Unpublished Fields Lab Data
    View Screen LOS1 HMO1 2 Unpublished Fields Lab Data
    View Screen TEM1 HMO1 2 Uetz P, et al. (2000)
    View Screen IMP4 HMO1 2 Unpublished Fields Lab Data
    View Screen YPR097W HMO1 2 Unpublished Fields Lab Data
    View Screen MSN5 HMO1 2 Uetz P, et al. (2000)
    View Screen YGR160W HMO1 2 Unpublished Fields Lab Data
    View Screen TRZ1 HMO1 1 Hazbun TR, et al. (2003)
    View Screen ZIM17 HMO1 1 Unpublished Fields Lab Data
    View Screen SPO21 HMO1 1 Unpublished Fields Lab Data
    View Screen PRP11 HMO1 1 Unpublished Fields Lab Data
    View Screen ACM1 HMO1 1 Unpublished Fields Lab Data
    View Screen PRP42 HMO1 1 Unpublished Fields Lab Data
    View Screen RRP17 HMO1 1 Unpublished Fields Lab Data
    View Screen RPN11 HMO1 1 Unpublished Fields Lab Data
    View Screen SGF73 HMO1 1 Unpublished Fields Lab Data
    View Screen PXR1 HMO1 1 Unpublished Fields Lab Data
    View Screen YPT35 HMO1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HMO1 Huh WK, et al. (2003)
    View Data HMO1 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..92] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [93..246] PSI-BLAST 44.325697 Upstream binding factor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA binding
    		•  5.15324651287773 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.01228762819617 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.9607192917135 bayes_pls_golite062009
  • transcription factor activity
    		•  3.82658263870186 bayes_pls_golite062009
  • binding
    		•  3.6211482127468 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.96229555092695 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.75319687398598 bayes_pls_golite062009
  • chromatin binding
    		•  1.64428658020027 bayes_pls_golite062009
  • transcription activator activity
    		•  1.62744929149746 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.53825678633232 bayes_pls_golite062009
  • protein binding
    		•  1.131658134984 bayes_pls_golite062009
  • transcription factor binding
    		•  1.10315330167937 bayes_pls_golite062009
  • DNA bending activity
    		•  0.87985209274756 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.261169200304829 bayes_pls_golite062009
  • RNA polymerase I transcription factor activity
    		•  0.0772111539778018 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle