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Protein Overview: TRZ1

General Information:
Name(s) found: TRZ1 / YKR079C [SGD]
Description(s) found:
Found 28 descriptions.
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  • tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 838 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: tRNA 3'-trailer cleavage [IDALink to PubMed article]
    Molecular Function: purine nucleotide binding [ISSLink to PubMed article]
    3'-tRNA processing endoribonuclease activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFTFIPITHP TSDTKHPLLL VQSAHGEKYF FGKIGEGSQR SLTENKIRIS KLKDIFLTGE  60
   61 LNWSDIGGLP GMILTIADQG KSNLVLHYGN DILNYIVSTW RYFVFRFGID LNDHIMKDKE 120
  121 VYKDKIIAVK SFNVLKNGGE DRLGVFDSFQ KGVLRSIVAK MFPKHAPTDR YDPSSDPHLN 180
  181 VELPDLDAKV EVSTNYEISF SPVRGKFKVE EAIKLGVPKG PLFAKLTKGQ TITLDNGIVV 240
  241 TPEQVLENER HFAKVLILDI PDDLYLNAFV EKFKDYDCAE LGMVYYFLGD EVTINDNLFA 300
  301 FIDIFEKNNY GKVNHMISHN KISPNTISFF GSALTTLKLK ALQVNNYNLP KTDRVFSKDF 360
  361 YDRFDTPLSR GTSMCKSQEE PLNTIIEKDN IHIFSQNKTV TFEPFRMNEE PMKCNINGEV 420
  421 ADFSWQEIFE EHVKPLEFPL ADVDTVINNQ LHVDNFNNSA EKKKHVEIIT LGTGSALPSK 480
  481 YRNVVSTLVK VPFTDADGNT INRNIMLDAG ENTLGTIHRM FSQLAVKSIF QDLKMIYLSH 540
  541 LHADHHLGII SVLNEWYKYN KDDETSYIYV VTPWQYHKFV NEWLVLENKE ILKRIKYISC 600
  601 EHFINDSFVR MQTQSVPLAE FNEILKENSN QESNRKLELD RDSSYRDVDL IRQMYEDLSI 660
  661 EYFQTCRAIH CDWAYSNSIT FRMDENNEHN TFKVSYSGDT RPNIEKFSLE IGYNSDLLIH 720
  721 EATLENQLLE DAVKKKHCTI NEAIGVSNKM NARKLILTHF SQRYPKLPQL DNNIDVMARE 780
  781 FCFAFDSMIV DYEKIGEQQR IFPLLNKAFV EEKEEEEDVD DVESVQDLEV KLKKHKKN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) NUC1 TRZ1
    View Details Hazbun TR, et al. (2003) NUC1 TRZ1 YMR099C
    View Details Gavin AC, et al. (2006) NUC1 TRZ1 YMR099C
    View Details Gavin AC, et al. (2002) NUC1 TRZ1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TRZ1 No Comments Hazbun TR, et al. (2003)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run TRZ1 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TRZ1 and YMR099C Hazbun TR, et al. (2003)
    View Data TRZ1 and NUC1 Hazbun TR, et al. (2003)
    View Data TRZ1 and TRX3 Hazbun TR, et al. (2003)
    View Data TRZ1 and SPC42 Hazbun TR, et al. (2003)
    View Data NUC1 and TRZ1 Unpublished Data
    View Data TRZ1 and SPC42 Unpublished Data
    View Data TRZ1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..204] Pcons 1.66 Glyoxalase II (hydroxyacylglutathione hydrolase)
    2 View Details [205..308] Pcons 1.66 Glyoxalase II (hydroxyacylglutathione hydrolase)
    3 View Details [309..456] deduced N/A No confident structure predictions are available.
    4 View Details [457..639] PSI-BLAST 4.30103 Rubredoxin oxygen:oxidoreductase (ROO), C-terminal domain; Rubredoxin oxygen:oxidoreductase (ROO), N-terminal domain
    5 View Details [640..838] MSA 3.267975 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.25638799652541 bayes_pls_golite062009
  • 3'-tRNA processing endoribonuclease activity
    		•  0.998280249151351 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.980281910076056 bayes_pls_golite062009
  • catalytic activity
    		•  0.941400907161877 bayes_pls_golite062009
  • RNA binding
    		•  0.794779546418275 bayes_pls_golite062009
  • protein binding
    		•  0.0732519352239051 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  1.31163219351982 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.995499818152009 bayes_pls_golite062009
  • catalytic activity
    		•  0.888964130802536 bayes_pls_golite062009
  • RNA binding
    		•  0.752641444664237 bayes_pls_golite062009
  • 3'-tRNA processing endoribonuclease activity
    		•  0.6076643116915 bayes_pls_golite062009
  • protein binding
    		•  0.104060533429009 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  1.25638799652541 bayes_pls_golite062009
  • 3'-tRNA processing endoribonuclease activity
    		•  0.998280249151351 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.980281910076056 bayes_pls_golite062009
  • catalytic activity
    		•  0.941400907161877 bayes_pls_golite062009
  • RNA binding
    		•  0.794779546418275 bayes_pls_golite062009
  • protein binding
    		•  0.0732519352239051 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle