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View Structure Prediction Details

Protein: TRZ1
Organism: Saccharomyces cerevisiae
Length: 838 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRZ1.

Description E-value Query
Range
Subject
Range
RNZ_YEAST - Ribonuclease Z OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRZ1 PE=1 SV=1
TRZ1 - tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetical...
0.0 [1..838] [1..838]
gi|22330184, gi|... - gi|22330184|ref|NP_175628.2| TRZ3 (TRNASE Z 3); 3'-tRNA processing endoribonuclease/ catalytic [Arab...
0.0 [4..831] [106..888]
gi|148678451, gi... - gi|148678451|gb|EDL10398.1| elaC homolog 2 (E. coli), isoform CRA_a [Mus musculus], gi|13540342|gb|A...
0.0 [4..826] [51..784]
gi|48146639, gi|... - gi|48146639|emb|CAG33542.1| ELAC2 [Homo sapiens], gi|21359941|ref|NP_060597.3| elaC homolog 2 [Homo ...
0.0 [4..813] [59..775]
RNZ2_GORGO - Zinc phosphodiesterase ELAC protein 2 OS=Gorilla gorilla gorilla GN=ELAC2 PE=2 SV=1
gi|10946489 - gi|10946489|gb|AAG24916.1|AF308694_1 ELAC2 [Gorilla gorilla]
0.0 [4..813] [59..775]
RNZ2_PANTR - Zinc phosphodiesterase ELAC protein 2 OS=Pan troglodytes GN=ELAC2 PE=2 SV=1
0.0 [4..813] [59..775]

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Predicted Domain #1
Region A:
Residues: [1-204]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFTFIPITHP TSDTKHPLLL VQSAHGEKYF FGKIGEGSQR SLTENKIRIS KLKDIFLTGE  60
   61 LNWSDIGGLP GMILTIADQG KSNLVLHYGN DILNYIVSTW RYFVFRFGID LNDHIMKDKE 120
  121 VYKDKIIAVK SFNVLKNGGE DRLGVFDSFQ KGVLRSIVAK MFPKHAPTDR YDPSSDPHLN 180
  181 VELPDLDAKV EVSTNYEISF SPVR

[Run NCBI BLAST on this sequence.]

Detection Method: Pcons
Confidence: 1.66
Match: 1qh5A
Description: Glyoxalase II (hydroxyacylglutathione hydrolase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.25638799652541 bayes_pls_golite062009
3'-tRNA processing endoribonuclease activity 0.998280249151351 bayes_pls_golite062009
nucleic acid binding 0.980281910076056 bayes_pls_golite062009
catalytic activity 0.941400907161877 bayes_pls_golite062009
RNA binding 0.794779546418275 bayes_pls_golite062009
protein binding 0.0732519352239051 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [205-308]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKFKVEEAIK LGVPKGPLFA KLTKGQTITL DNGIVVTPEQ VLENERHFAK VLILDIPDDL  60
   61 YLNAFVEKFK DYDCAELGMV YYFLGDEVTI NDNLFAFIDI FEKN

[Run NCBI BLAST on this sequence.]

Detection Method: Pcons
Confidence: 1.66
Match: 1qh5A
Description: Glyoxalase II (hydroxyacylglutathione hydrolase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.31163219351982 bayes_pls_golite062009
nucleic acid binding 0.995499818152009 bayes_pls_golite062009
catalytic activity 0.888964130802536 bayes_pls_golite062009
RNA binding 0.752641444664237 bayes_pls_golite062009
3'-tRNA processing endoribonuclease activity 0.6076643116915 bayes_pls_golite062009
protein binding 0.104060533429009 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [309-456]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYGKVNHMIS HNKISPNTIS FFGSALTTLK LKALQVNNYN LPKTDRVFSK DFYDRFDTPL  60
   61 SRGTSMCKSQ EEPLNTIIEK DNIHIFSQNK TVTFEPFRMN EEPMKCNING EVADFSWQEI 120
  121 FEEHVKPLEF PLADVDTVIN NQLHVDNF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [457-639]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNSAEKKKHV EIITLGTGSA LPSKYRNVVS TLVKVPFTDA DGNTINRNIM LDAGENTLGT  60
   61 IHRMFSQLAV KSIFQDLKMI YLSHLHADHH LGIISVLNEW YKYNKDDETS YIYVVTPWQY 120
  121 HKFVNEWLVL ENKEILKRIK YISCEHFIND SFVRMQTQSV PLAEFNEILK ENSNQESNRK 180
  181 LEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.30103
Match: 1e5dA_
Description: Rubredoxin oxygen:oxidoreductase (ROO), C-terminal domain; Rubredoxin oxygen:oxidoreductase (ROO), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.25638799652541 bayes_pls_golite062009
3'-tRNA processing endoribonuclease activity 0.998280249151351 bayes_pls_golite062009
nucleic acid binding 0.980281910076056 bayes_pls_golite062009
catalytic activity 0.941400907161877 bayes_pls_golite062009
RNA binding 0.794779546418275 bayes_pls_golite062009
protein binding 0.0732519352239051 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [640-838]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRDSSYRDVD LIRQMYEDLS IEYFQTCRAI HCDWAYSNSI TFRMDENNEH NTFKVSYSGD  60
   61 TRPNIEKFSL EIGYNSDLLI HEATLENQLL EDAVKKKHCT INEAIGVSNK MNARKLILTH 120
  121 FSQRYPKLPQ LDNNIDVMAR EFCFAFDSMI VDYEKIGEQQ RIFPLLNKAF VEEKEEEEDV 180
  181 DDVESVQDLE VKLKKHKKN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle