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Protein Overview: MSH6

General Information:
Name(s) found: MSH6 / YDR097C [SGD]
Description(s) found:
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  • gi|633631|emb|CAA87671.1| probable DNA repair protein [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6320302|ref|NP_010382.1| Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p; Msh6p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|3024187|sp|Q03834.1|MSH6_YEAST RecName: Full=DNA mismatch repair protein MSH6; AltName: Full=MutS protein homolog 6; AltName: Full=Postmeiotic segregation protein 3 [NCBI NR]
  • pir||S51246 probable DNA repair protein YDR097c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • DNA mismatch repair protein MSH6 OS=Saccharomyces cerevisiae GN=MSH6 PE=1 SV=1 [Swiss-Prot]
  • MSH6 DNA mismatch repair protein [mips]
  • Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p [SGD]
  • MSH6, Chr IV from 640102-643830, reverse complement [yeast_orfs2]
  • Chr IV from 640102-643830, reverse complement [yeastorf3.fasta]
  • Chr IV from 643830-640102, reverse complement [yeastorf5.fasta]
  • (Q03834) MUTS protein homolog 6 [4932.FASTACCERV.txt]
  • MSH6 SGDID:S0002504, Chr IV from 643831-640103, reverse complement, Verified ORF [yeastflysequest.fasta]
  • MSH6 SGDID:S0002504, Chr IV from 643832-640104, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Msh6p [Saccharomyces cerevisiae]gi|633631|emb|CAA87671.1| probable DNA repair protein [Saccharomyces cerevisiae]gi|3024187|sp|Q03834|MSH6_YEAST MUTS protein homolog 6gi|1078208|pir||S51246 probable DNA repair protein YDR097c - yeast (Saccharomyces cere [nrdb_11152004_Chlamydomonas]
  • MSH6 SGDID:S000002504, Chr IV from 643832-640104, reverse complement, Verified ORF, "Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylat [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • MSH6 SGDID:S000002504, Chr IV from 643834-640106, reverse complement, Verified ORF, "Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylat [yeast-contam.fasta]
  • MSH6 SGDID:S000002504, Chr IV from 643835-640107, reverse complement, Verified ORF, "Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylat [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p; Msh6p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • probable DNA repair protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • MutS protein homolog 6 [nr-271106-contam.fasta]
  • MSH6 SGDID:S000002504, Chr IV from 643835-640107, reverse complement, Verified ORF, "Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p" [yeast-bovrabprots.fasta]
  • MSH6 SGDID:S000002504, Chr IV from 643834-640106, reverse complement, Verified ORF, "Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • DNA mismatch repair protein MSH6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSH6 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MSH6 SGDID:S000002504, Chr IV from 643837-640109, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p" [yeast-030211-contam.fasta]
  • MSH6 SGDID:S000002504, Chr IV from 643837-640109, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein required for mismatch repair in mitosis and meiosis; forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p" [20141208_orf_trans.fasta]
  • YDR097C SGDID:S000002504, Chr IV from 643837-640109, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1242 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: meiotic mismatch repair [IMPLink to PubMed article]
    mismatch repair [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: ATPase activity [IDALink to PubMed article]
    ATP binding [IDALink to PubMed article]
    four-way junction DNA binding [IDALink to PubMed article]
    guanine/thymine mispair binding [IDALink to PubMed article]
    single base insertion or deletion binding [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPATPKTSK TAHFENGSTS SQKKMKQSSL LSFFSKQVPS GTPSKKVQKP TPATLENTAT  60
   61 DKITKNPQGG KTGKLFVDVD EDNDLTIAEE TVSTVRSDIM HSQEPQSDTM LNSNTTEPKS 120
  121 TTTDEDLSSS QSRRNHKRRV NYAESDDDDS DTTFTAKRKK GKVVDSESDE DEYLPDKNDG 180
  181 DEDDDIADDK EDIKGELAED SGDDDDLISL AETTSKKKFS YNTSHSSSPF TRNISRDNSK 240
  241 KKSRPNQAPS RSYNPSHSQP SATSKSSKFN KQNEERYQWL VDERDAQRRP KSDPEYDPRT 300
  301 LYIPSSAWNK FTPFEKQYWE IKSKMWDCIV FFKKGKFFEL YEKDALLANA LFDLKIAGGG 360
  361 RANMQLAGIP EMSFEYWAAQ FIQMGYKVAK VDQRESMLAK EMREGSKGIV KRELQCILTS 420
  421 GTLTDGDMLH SDLATFCLAI REEPGNFYNE TQLDSSTIVQ KLNTKIFGAA FIDTATGELQ 480
  481 MLEFEDDSEC TKLDTLMSQV RPMEVVMERN NLSTLANKIV KFNSAPNAIF NEVKAGEEFY 540
  541 DCDKTYAEII SSEYFSTEED WPEVLKSYYD TGKKVGFSAF GGLLYYLKWL KLDKNLISMK 600
  601 NIKEYDFVKS QHSMVLDGIT LQNLEIFSNS FDGSDKGTLF KLFNRAITPM GKRMMKKWLM 660
  661 HPLLRKNDIE SRLDSVDSLL QDITLREQLE ITFSKLPDLE RMLARIHSRT IKVKDFEKVI 720
  721 TAFETIIELQ DSLKNNDLKG DVSKYISSFP EGLVEAVKSW TNAFERQKAI NENIIVPQRG 780
  781 FDIEFDKSMD RIQELEDELM EILMTYRKQF KCSNIQYKDS GKEIYTIEIP ISATKNVPSN 840
  841 WVQMAANKTY KRYYSDEVRA LARSMAEAKE IHKTLEEDLK NRLCQKFDAH YNTIWMPTIQ 900
  901 AISNIDCLLA ITRTSEYLGA PSCRPTIVDE VDSKTNTQLN GFLKFKSLRH PCFNLGATTA 960
  961 KDFIPNDIEL GKEQPRLGLL TGANAAGKST ILRMACIAVI MAQMGCYVPC ESAVLTPIDR1020
 1021 IMTRLGANDN IMQGKSTFFV ELAETKKILD MATNRSLLVV DELGRGGSSS DGFAIAESVL1080
 1081 HHVATHIQSL GFFATHYGTL ASSFKHHPQV RPLKMSILVD EATRNVTFLY KMLEGQSEGS1140
 1141 FGMHVASMCG ISKEIIDNAQ IAADNLEHTS RLVKERDLAA NNLNGEVVSV PGGLQSDFVR1200
 1201 IAYGDGLKNT KLGSGEGVLN YDWNIKRNVL KSLFSIIDDL QS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MPH1 MSH2 MSH6
    View Details (MIPS) Mewes HW, et al. (2004) MSH2 MSH6
    View Details Krogan NJ, et al. (2006) MSH2 MSH6
    View Details Gavin AC, et al. (2006) MPH1 MSH6 RAD52 RFA1
    View Details Gavin AC, et al. (2002) CMR1 DNA2 ECM29 HDA1 HDA2 HDA3 HSC82 KAP95 LCD1 MEC1 MGM101 MLH1 MPH1 MRPS28 MSH2 MSH3 MSH6 OLA1 PGK1 PMS1 PRO2 RAD16 RAD23 RAD34 RAD4 RAD52 RFA1 RFA2 RFA3 RIM1 RNH1 RPN10 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT6 RSC8 RVB2 SGS1 SHS1 SRO7 SSL1 TFA1 TFB1 TFB4 TIF1, TIF2 TOP3 VAS1 VPS1 YHR122W
    View Details Ho Y, et al. (2002) MSH2 MSH6
    View Details Qiu et al. (2008) MSH2 MSH3 MSH6

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MSH6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..248] ORFEUS 10.28 No description for 1ldvA was found.
    2 View Details [249..303] ORFEUS 8.11 RBP1
    3 View Details [304..417] PSI-BLAST 1615.228787 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    4 View Details [418..611] PSI-BLAST 1615.228787 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    5 View Details [612..637]
    [917..1190]    		 PSI-BLAST 1615.228787 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    6 View Details [638..792]
    [867..916]    		 PSI-BLAST 1615.228787 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    7 View Details [793..866] PSI-BLAST 1615.228787 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    8 View Details [1191..1242] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle