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Complex Overview

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CMR1
  • nucleus
  • cytoplasm
  • biological_process
  • molecular_function
  • DNA2
  • nucleus
  • nuclear chromosome, telomeric region
  • DNA repair
  • lagging strand elongation
  • DNA-dependent DNA replication
  • telomere maintenance
  • replicative cell aging
  • 5'-flap endonuclease activity
  • ATP-dependent DNA helicase activity
  • single-stranded DNA specific endodeoxyribonuclease activity
  • HDA1
  • histone deacetylase complex
  • loss of chromatin silencing involved in replicative cell aging
  • regulation of transcription, DNA-dependent
  • protein amino acid deacetylation
  • chromatin organization
  • histone deacetylase activity
  • HDA2
  • nucleus
  • histone deacetylase complex
  • telomere maintenance
  • regulation of transcription, DNA-dependent
  • histone deacetylation
  • histone deacetylase activity
  • HDA3
  • nucleus
  • histone deacetylase complex
  • regulation of transcription, DNA-dependent
  • histone deacetylation
  • histone deacetylase activity
  • HSC82
  • cytoplasm
  • mitochondrion
  • telomere maintenance
  • protein folding
  • protein refolding
  • proteasome assembly
  • 'de novo' protein folding
  • response to stress
  • unfolded protein binding
  • ATPase activity, coupled
  • KAP95
  • cytoplasm
  • nuclear pore
  • protein import into nucleus
  • nuclear pore complex assembly
  • protein transmembrane transporter activity
  • LCD1
  • nuclear chromosome
  • establishment of protein localization
  • DNA damage checkpoint
  • telomere maintenance via telomerase
  • protein binding
  • damaged DNA binding
  • MEC1
  • nucleus
  • mitochondrion
  • DNA damage checkpoint
  • DNA replication checkpoint
  • reciprocal meiotic recombination
  • DNA recombination
  • telomere maintenance
  • telomere maintenance via recombination
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • protein kinase activity
  • MGM101
  • mitochondrial chromosome
  • mitochondrion
  • mitochondrial nucleoid
  • DNA repair
  • mitochondrial genome maintenance
  • DNA binding
  • MLH1
  • nucleus
  • mitochondrion
  • reciprocal meiotic recombination
  • meiotic mismatch repair
  • ATPase activity
  • DNA binding
  • ATP binding
  • MPH1
  • nucleus
  • DNA repair
  • RNA helicase activity
  • 3'-5' DNA helicase activity
  • MSH2
  • nucleus
  • nuclear chromosome
  • removal of nonhomologous ends
  • DNA recombination
  • meiotic gene conversion
  • meiotic mismatch repair
  • mismatch repair
  • chromatin silencing at silent mating-type cassette
  • mitotic recombination
  • ATPase activity
  • ATP binding
  • double-strand/single-strand DNA junction binding
  • DNA insertion or deletion binding
  • loop DNA binding
  • Y-form DNA binding
  • four-way junction DNA binding
  • guanine/thymine mispair binding
  • single base insertion or deletion binding
  • MSH3
  • nucleus
  • cytoplasm
  • removal of nonhomologous ends
  • DNA recombination
  • meiotic mismatch repair
  • mismatch repair
  • mitotic recombination
  • double-strand/single-strand DNA junction binding
  • DNA insertion or deletion binding
  • loop DNA binding
  • Y-form DNA binding
  • MSH6
  • nucleus
  • meiotic mismatch repair
  • mismatch repair
  • ATPase activity
  • ATP binding
  • four-way junction DNA binding
  • guanine/thymine mispair binding
  • single base insertion or deletion binding
  • OLA1
  • cytoplasm
  • biological_process
  • molecular_function
  • PGK1
  • cytoplasm
  • mitochondrion
  • gluconeogenesis
  • glycolysis
  • phosphoglycerate kinase activity
  • PMS1
  • nuclear chromosome
  • meiotic mismatch repair
  • mismatch repair
  • meiosis
  • ATPase activity
  • DNA binding
  • ATP binding
  • PRO2
  • nucleus
  • cytoplasm
  • proline biosynthetic process
  • glutamate-5-semialdehyde dehydrogenase activity
  • RAD16
  • repairosome
  • nucleotide-excision repair factor 4 complex
  • nucleotide-excision repair, DNA damage recognition
  • DNA-dependent ATPase activity
  • damaged DNA binding
  • RAD52
  • nucleus
  • nuclear chromosome
  • meiotic DNA recombinase assembly
  • double-strand break repair via break-induced replication
  • double-strand break repair via single-strand annealing
  • telomere maintenance via recombination
  • double-strand break repair via synthesis-dependent strand annealing
  • DNA recombinase assembly
  • postreplication repair
  • DNA strand annealing activity
  • recombinase activity
  • RFA1
  • chromosome, telomeric region
  • nucleus
  • cytoplasm
  • DNA replication factor A complex
  • DNA strand elongation involved in DNA replication
  • double-strand break repair via homologous recombination
  • DNA recombination
  • nucleotide-excision repair
  • telomere maintenance via recombination
  • DNA unwinding involved in replication
  • postreplication repair
  • DNA replication, synthesis of RNA primer
  • damaged DNA binding
  • single-stranded DNA binding
  • RFA2
  • chromosome, telomeric region
  • DNA replication factor A complex
  • DNA strand elongation involved in DNA replication
  • double-strand break repair via homologous recombination
  • DNA recombination
  • nucleotide-excision repair
  • DNA unwinding involved in replication
  • postreplication repair
  • DNA replication, synthesis of RNA primer
  • DNA binding
  • RFA3
  • chromosome, telomeric region
  • DNA replication factor A complex
  • DNA strand elongation involved in DNA replication
  • double-strand break repair via homologous recombination
  • DNA recombination
  • nucleotide-excision repair
  • DNA unwinding involved in replication
  • postreplication repair
  • DNA replication, synthesis of RNA primer
  • DNA binding
  • RIM1
  • mitochondrion
  • mitochondrial nucleoid
  • mitochondrial genome maintenance
  • single-stranded DNA binding
  • RNH1
  • nucleus
  • intracellular
  • cellular cell wall organization
  • DNA replication, removal of RNA primer
  • ribonuclease H activity
  • RSC8
  • nucleus
  • RSC complex
  • ATP-dependent chromatin remodeling
  • double-strand break repair via nonhomologous end joining
  • DNA-dependent ATPase activity
  • RVB2
  • nucleus
  • Swr1 complex
  • Ino80 complex
  • nuclear outer membrane
  • chromatin remodeling complex
  • chromatin remodeling
  • snoRNA metabolic process
  • regulation of transcription from RNA polymerase II promoter
  • ATPase activity
  • ATP-dependent 5'-3' DNA helicase activity
  • SGS1
  • nucleolus
  • RecQ helicase-Topo III complex
  • meiotic chromosome segregation
  • mitotic sister chromatid segregation
  • telomere maintenance via recombination
  • response to DNA damage stimulus
  • replicative cell aging
  • DNA unwinding involved in replication
  • ATP-dependent DNA helicase activity
  • SHS1
  • septin ring
  • cell morphogenesis
  • cytokinesis
  • structural constituent of cytoskeleton
  • TIF1, TIF2
  • plasma membrane enriched fraction
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • regulation of translation
  • translational initiation
  • regulation of translational initiation
  • translation
  • nucleotide binding
  • nucleic acid binding
  • translation initiation factor activity
  • ATP binding
  • RNA binding
  • ATP-dependent helicase activity
  • helicase activity
  • ATP-dependent RNA helicase activity
  • hydrolase activity
  • TOP3
  • nucleus
  • RecQ helicase-Topo III complex
  • reciprocal meiotic recombination
  • telomere maintenance via telomerase
  • regulation of DNA recombination
  • DNA topoisomerase type I activity
  • VAS1
  • cytoplasm
  • mitochondrion
  • valyl-tRNA aminoacylation
  • valine-tRNA ligase activity
  • VPS1
  • membrane fraction
  • peroxisome
  • cytoplasm
  • mitochondrial outer membrane
  • protein retention in Golgi apparatus
  • peroxisome organization
  • vacuolar transport
  • protein targeting to vacuole
  • actin cytoskeleton organization
  • GTPase activity
  • YHR122W
  • nucleus
  • cytoplasm
  • transcription
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    chromosome 1.2461E-8 35 274 12 6292
    DNA replication factor A complex 1.5773E-7 35 3 3 6292
    nucleus 4.4095E-7 35 2041 26 6292
    nuclear chromosome 2.8524E-6 35 228 9 6292
    intracellular organelle 4.5973E-6 35 4070 34 6292
    organelle 4.6341E-6 35 4071 34 6292
    chromosome, telomeric region 1.2861E-5 35 27 4 6292
    membrane-bounded organelle 3.5696E-5 35 3771 32 6292
    intracellular membrane-bounded organelle 3.5696E-5 35 3771 32 6292
    non-membrane-bounded organelle 8.0204E-5 35 959 15 6292
    intracellular non-membrane-bounded organelle 8.0204E-5 35 959 15 6292
    RecQ helicase-Topo III complex 8.9875E-5 35 3 2 6292
    nuclear part 1.0243E-4 35 1103 16 6292
    replisome 1.2154E-4 35 18 3 6292
    nuclear replisome 1.2154E-4 35 18 3 6292
    nuclear replication fork 1.685E-4 35 20 3 6292
    chromatin remodeling complex 1.9452E-4 35 99 5 6292
    intracellular part 2.0201E-4 35 4938 35 6292
    histone deacetylase complex 2.5879E-4 35 23 3 6292
    intracellular 2.6256E-4 35 4975 35 6292
    chromosomal part 2.6822E-4 35 237 7 6292
    replication fork 1.5604E-3 35 42 3 6292
    intracellular organelle part 3.5391E-3 35 2282 21 6292
    organelle part 3.5391E-3 35 2282 21 6292
    nuclear chromosome part 3.7013E-3 35 190 5 6292
    protein-DNA complex 3.7569E-3 35 57 3 6292
    cell part 4.5803E-3 35 5397 35 6292
    cell 4.6403E-3 35 5399 35 6292
    plasma membrane enriched fraction 5.5626E-3 35 1 1 6292
    protein complex 5.8826E-3 35 1137 13 6292
    nucleoid 8.9854E-3 35 26 2 6292
    mitochondrial nucleoid 8.9854E-3 35 26 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    response to DNA damage stimulus 8.0889E-16 35 236 17 6292
    cellular response to stress 2.5817E-14 35 290 17 6292
    DNA metabolic process 1.0289E-13 35 585 21 6292
    DNA repair 5.0055E-13 35 192 14 6292
    cellular response to stimulus 2.1266E-12 35 379 17 6292
    response to stress 1.3626E-11 35 497 18 6292
    nucleic acid metabolic process 9.6517E-11 35 1415 26 6292
    DNA recombination 3.2137E-10 35 114 10 6292
    meiotic mismatch repair 4.9065E-10 35 9 5 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.0535E-9 35 1566 26 6292
    cellular nitrogen compound metabolic process 2.2579E-9 35 1770 27 6292
    nitrogen compound metabolic process 3.0041E-9 35 1791 27 6292
    meiosis I 7.7081E-9 35 79 8 6292
    DNA replication 1.4302E-8 35 123 9 6292
    response to stimulus 1.7169E-8 35 766 18 6292
    mitotic recombination 1.8788E-8 35 33 6 6292
    meiosis 1.4229E-7 35 160 9 6292
    M phase of meiotic cell cycle 1.4229E-7 35 160 9 6292
    meiotic cell cycle 1.7602E-7 35 164 9 6292
    DNA-dependent DNA replication 2.4684E-7 35 82 7 6292
    mismatch repair 2.926E-7 35 27 5 6292
    chromosome organization 5.9493E-7 35 555 14 6292
    DNA strand elongation 6.0609E-7 35 31 5 6292
    DNA strand elongation involved in DNA replication 6.0609E-7 35 31 5 6292
    DNA unwinding involved in replication 7.7223E-7 35 14 4 6292
    cellular macromolecule metabolic process 9.3716E-7 35 2285 27 6292
    telomere maintenance via recombination 1.393E-6 35 16 4 6292
    DNA replication, synthesis of RNA primer 1.5652E-6 35 5 3 6292
    macromolecule metabolic process 1.7583E-6 35 2349 27 6292
    postreplication repair 2.3236E-6 35 18 4 6292
    DNA geometric change 3.6502E-6 35 20 4 6292
    DNA duplex unwinding 3.6502E-6 35 20 4 6292
    double-strand break repair via homologous recombination 5.4677E-6 35 22 4 6292
    organelle organization 6.5615E-6 35 1127 18 6292
    primary metabolic process 7.6938E-6 35 2896 29 6292
    recombinational repair 1.0999E-5 35 26 4 6292
    double-strand break repair 1.3465E-5 35 57 5 6292
    anatomical structure homeostasis 1.815E-5 35 286 9 6292
    telomere organization 1.815E-5 35 286 9 6292
    telomere maintenance 1.815E-5 35 286 9 6292
    M phase 2.264E-5 35 294 9 6292
    cellular metabolic process 2.3505E-5 35 3033 29 6292
    nucleotide-excision repair 5.1796E-5 35 38 4 6292
    cellular component organization 5.3231E-5 35 1582 20 6292
    metabolic process 6.0866E-5 35 3157 29 6292
    cellular macromolecule biosynthetic process 6.2617E-5 35 1187 17 6292
    macromolecule biosynthetic process 6.4031E-5 35 1189 17 6292
    cell cycle phase 1.5518E-4 35 376 9 6292
    cellular biosynthetic process 1.8088E-4 35 1567 19 6292
    biosynthetic process 2.4732E-4 35 1602 19 6292
    DNA conformation change 2.7512E-4 35 58 4 6292
    homeostatic process 2.8806E-4 35 408 9 6292
    removal of nonhomologous ends 2.9749E-4 35 5 2 6292
    cell cycle 4.0596E-4 35 525 10 6292
    DNA catabolic process, endonucleolytic 4.4468E-4 35 6 2 6292
    protein amino acid deacetylation 5.2188E-4 35 29 3 6292
    cellular process 5.3209E-4 35 4426 33 6292
    regulation of biological quality 5.9811E-4 35 551 10 6292
    cell cycle process 1.1038E-3 35 490 9 6292
    biological regulation 1.148E-3 35 1213 15 6292
    replicative cell aging 1.1643E-3 35 38 3 6292
    reciprocal meiotic recombination 1.4545E-3 35 41 3 6292
    gene conversion at mating-type locus 1.6022E-3 35 11 2 6292
    chromatin modification 2.1688E-3 35 168 5 6292
    telomere maintenance via telomerase 2.2564E-3 35 13 2 6292
    RNA-dependent DNA replication 2.2564E-3 35 13 2 6292
    telomere maintenance via telomere lengthening 2.2564E-3 35 13 2 6292
    cell aging 2.4386E-3 35 49 3 6292
    DNA damage checkpoint 2.6233E-3 35 14 2 6292
    DNA damage response, signal transduction 2.6233E-3 35 14 2 6292
    aging 2.7355E-3 35 51 3 6292
    DNA catabolic process 3.0164E-3 35 15 2 6292
    mating type switching 3.4353E-3 35 16 2 6292
    lagging strand elongation 4.3495E-3 35 18 2 6292
    regulation of macromolecule metabolic process 4.4754E-3 35 488 8 6292
    chromatin organization 4.9093E-3 35 203 5 6292
    DNA integrity checkpoint 5.3639E-3 35 20 2 6292
    mating type determination 5.3639E-3 35 20 2 6292
    sex determination 5.3639E-3 35 20 2 6292
    DNA replication, removal of RNA primer 5.5626E-3 35 1 1 6292
    pore complex assembly 5.5626E-3 35 1 1 6292
    nuclear pore complex assembly 5.5626E-3 35 1 1 6292
    DNA replication, Okazaki fragment processing 5.5626E-3 35 1 1 6292
    valyl-tRNA aminoacylation 5.5626E-3 35 1 1 6292
    meiotic gene conversion 5.5626E-3 35 1 1 6292
    RNA biosynthetic process 5.7114E-3 35 508 8 6292
    regulation of primary metabolic process 6.1294E-3 35 514 8 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 6.9141E-3 35 415 7 6292
    regulation of nitrogen compound metabolic process 7.0043E-3 35 416 7 6292
    cell fate commitment 7.0682E-3 35 23 2 6292
    regulation of cellular metabolic process 7.8678E-3 35 536 8 6292
    regulation of metabolic process 8.8673E-3 35 547 8 6292
    developmental process 9.0036E-3 35 331 6 6292
    histone deacetylation 9.6706E-3 35 27 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DNA binding 2.5872E-11 35 256 14 6292
    nucleoside-triphosphatase activity 8.9716E-9 35 329 13 6292
    ATPase activity 9.5711E-9 35 211 11 6292
    pyrophosphatase activity 2.0994E-8 35 353 13 6292
    hydrolase activity, acting on acid anhydrides 2.0994E-8 35 353 13 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.0994E-8 35 353 13 6292
    structure-specific DNA binding 1.1463E-7 35 44 6 6292
    ATP binding 1.5591E-7 35 24 5 6292
    adenyl ribonucleotide binding 1.9411E-7 35 25 5 6292
    adenyl nucleotide binding 5.1037E-7 35 30 5 6292
    purine nucleoside binding 6.0609E-7 35 31 5 6292
    nucleoside binding 7.1547E-7 35 32 5 6292
    nucleic acid binding 8.5986E-7 35 666 15 6292
    DNA insertion or deletion binding 1.5652E-6 35 5 3 6292
    mismatched DNA binding 1.5652E-6 35 5 3 6292
    hydrolase activity 1.6128E-6 35 911 17 6292
    ribonucleotide binding 2.5687E-6 35 41 5 6292
    purine ribonucleotide binding 2.5687E-6 35 41 5 6292
    double-stranded DNA binding 6.5926E-6 35 23 4 6292
    purine nucleotide binding 8.5261E-6 35 52 5 6292
    DNA-dependent ATPase activity 1.1277E-5 35 55 5 6292
    DNA secondary structure binding 1.2949E-5 35 9 3 6292
    ATPase activity, coupled 1.3983E-5 35 149 7 6292
    nucleotide binding 1.5972E-5 35 59 5 6292
    damaged DNA binding 2.5241E-5 35 11 3 6292
    single base insertion or deletion binding 3.0063E-5 35 2 2 6292
    DNA helicase activity 3.306E-5 35 34 4 6292
    single-stranded DNA binding 8.4047E-5 35 16 3 6292
    helicase activity 8.4171E-5 35 83 5 6292
    guanine/thymine mispair binding 8.9875E-5 35 3 2 6292
    double-strand/single-strand DNA junction binding 8.9875E-5 35 3 2 6292
    loop DNA binding 8.9875E-5 35 3 2 6292
    Y-form DNA binding 8.9875E-5 35 3 2 6292
    ATP-dependent DNA helicase activity 1.2154E-4 35 18 3 6292
    purine NTP-dependent helicase activity 1.3125E-4 35 48 4 6292
    ATP-dependent helicase activity 1.3125E-4 35 48 4 6292
    catalytic activity 1.3275E-4 35 2150 23 6292
    four-way junction DNA binding 1.7912E-4 35 4 2 6292
    binding 1.9329E-4 35 1294 17 6292
    histone deacetylase activity 7.0035E-4 35 32 3 6292
    protein deacetylase activity 7.0035E-4 35 32 3 6292
    deacetylase activity 9.1366E-4 35 35 3 6292
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2.298E-3 35 48 3 6292
    glutamate-5-semialdehyde dehydrogenase activity 5.5626E-3 35 1 1 6292
    valine-tRNA ligase activity 5.5626E-3 35 1 1 6292
    endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 7.0682E-3 35 23 2 6292
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 9.6687E-3 35 80 3 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle