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Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: DNA topoisomerase type I activity
Acc: GO:0003917
Aspect: Molecular Function
Desc: Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
Synonyms:
  • DNA topoisomerase I activity
  • nicking-closing enzyme activity
  • swivelase activity
  • omega-protein activity
  • topoisomerase
  • untwisting enzyme activity
  • deoxyribonucleate topoisomerase
  • type I DNA topoisomerase activity
  • type I topoisomerase activity
  • relaxing enzyme activity
Proteins in PDR annotated with:
   This term: 46 [Search]
   Term or descendants: 46 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0003917 - DNA topoisomerase type I activity (interactive image map)

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