YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: SLA1

General Information:
Name(s) found: SLA1 / YBL007C [SGD]
Description(s) found:
Found 30 descriptions.
SHOW ALL
  • Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1244 amino acids

    Gene Ontology:
    Cellular Component: actin cortical patch [IDALink to PubMed article]
    Biological Process: bipolar cellular bud site selection [IMPLink to PubMed article]
    cellular cell wall organization [IMPLink to PubMed article]
    actin filament organization [IMPLink to PubMed article][IPILink to PubMed article]
    endocytosis [IMPLink to PubMed article][IPILink to PubMed article]
    actin cortical patch assembly [TASLink to PubMed article]
    Molecular Function: ubiquitin binding [IDALink to PubMed article]
    cytoskeletal protein binding [IMPLink to PubMed article][IPILink to PubMed article]
    protein binding, bridging [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVFLGIYRA VYAYEPQTPE ELAIQEDDLL YLLQKSDIDD WWTVKKRVIG SDSEEPVGLV  60
   61 PSTYIEEAPV LKKVRAIYDY EQVQNADEEL TFHENDVFDV FDDKDADWLL VKSTVSNEFG 120
  121 FIPGNYVEPE NGSTSKQEQA PAAAEAPAAT PAAAPASAAV LPTNFLPPPQ HNDRARMMQS 180
  181 KEDQAPDEDE EGPPPAMPAR PTATTETTDA TAAAVRSRTR LSYSDNDNDD EEDDYYYNSN 240
  241 SNNVGNHEYN TEYHSWNVTE IEGRKKKKAK LSIGNNKINF IPQKGTPHEW SIDKLVSYDN 300
  301 EKKHMFLEFV DPYRSLELHT GNTTTCEEIM NIIGEYKGAS RDPGLREVEM ASKSKKRGIV 360
  361 QYDFMAESQD ELTIKSGDKV YILDDKKSKD WWMCQLVDSG KSGLVPAQFI EPVRDKKHTE 420
  421 STASGIIKSI KKNFTKSPSR SRSRSRSKSN ANASWKDDEL QNDVVGSAAG KRSRKSSLSS 480
  481 HKKNSSATKD FPNPKKSRLW VDRSGTFKVD AEFIGCAKGK IHLHKANGVK IAVAADKLSN 540
  541 EDLAYVEKIT GFSLEKFKAN DGSSSRGTDS RDSERERRRR LKEQEEKERD RRLKERELYE 600
  601 LKKARELLDE ERSRLQEKEL PPIKPPRPTS TTSVPNTTSV PPAESSNNNN SSNKYDWFEF 660
  661 FLNCGVDVSN CQRYTINFDR EQLTEDMMPD INNSMLRTLG LREGDIVRVM KHLDKKFGRE 720
  721 NIASIPTNAT GNMFSQPDGS LNVATSPETS LPQQLLPQTT SPAQTAPSTS AETDDAWTVK 780
  781 PASKSESNLL SKKSEFTGSM QDLLDLQPLE PKKAAASTPE PNLKDLEPVK TGGTTVPAAP 840
  841 VSSAPVSSAP APLDPFKTGG NNILPLSTGF VMMPMITGGD MLPMQRTGGF VVPQTTFGMQ 900
  901 SQVTGGILPV QKTGNGLIPI SNTGGAMMPQ TTFGAAATVL PLQKTGGGLI PIATTGGAQF 960
  961 PQTSFNVQGQ QQLPTGSILP VQKTANGLIS ANTGVSMPTV QRTGGTMIPQ TSFGVSQQLT1020
 1021 GGAMMTQPQN TGSAMMPQTS FNAVPQITGG AMMPQTSFNA LPQVTGGAMM PLQRTGGALN1080
 1081 TFNTGGAMIP QTSFSSQAQN TGGFRPQSQF GLTLQKTGGI APLNQNQFTG GAMNTLSTGG1140
 1141 VLQQQQPQTM NTFNTGGVMQ ELQMMTTFNT GGAMQQPQMM NTFNTDGIMQ QPQMMNTFNT1200
 1201 GGAMQQPQQQ ALQNQPTGFG FGNGPQQSRQ ANIFNATASN PFGF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BZZ1 LAS17 SLA1 VRP1
    View Details (MIPS) Mewes HW, et al. (2004) ABP1 AIP1 ARC40 ARP2 BEM1 BUD6 CAP1 CAP2 COF1 CRN1 DLD2 GLK1 LAS17 OYE2 PAN1 PFY1 RVS167 SAC6 SLA1 SLA2 SRV2 TPM1 TPM2 TWF1 VRP1
    View Details Krogan NJ, et al. (2006) BZZ1 LAS17 MEC1 SLA1 VRP1
    View Details Gavin AC, et al. (2006) LAS17 LSB3 SLA1
    View Details Gavin AC, et al. (2002) BSP1 BZZ1 CHC1 ECM25 END3 INP52 LAS17 LSB3 RAD51 SLA1 SLA2 STM1 SYP1 TFP1 VRP1 YPT7 YSC84
    View Details Ho Y, et al. (2002) AAC3 BZZ1 GAL2 HXT6 HXT7 LAS17 MYO4 PEP1 PHO84 RPN1 RPN12 RVS167 SLA1 SQT1 VMA6 VRP1 YHM2 YNR065C
    View Details Qiu et al. (2008) ABP1 ABP140 AIP1 ARC40 ARK1 ARP2 BBC1 BEM1 BNI1 BNI4 BSP1 BUD6 BZZ1 CAP1 CAP2 COF1 CRN1 EDE1 END3 ENT1 ENT2 ENT3 ENT4 HOF1 INP53 IQG1 LAS17 MYO3 MYO5 PAN1 PFY1 PRK1 RVS161 RVS167 SAC6 SCD5 SCP1 SLA1 SLA2 SPA2 SRV2 TPM1 TPM2 TWF1 VRP1 YSC84

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TID3 No Comments Cheeseman IM, et al. (2002)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SLA1 SNA3 2 Unpublished Fields Lab Data
    View Screen SLA1 ECM25 2 Unpublished Fields Lab Data
    View Screen SLA1 BSP1 2 Drees BL, et al. (2001)
    View Screen GTS1 SLA1 2 Unpublished Fields Lab Data
    View Screen SLA1 MMS4 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SLA1 and SAC6 Huh WK, et al. (2003)
    View Data SLA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..73] ORFEUS 11.86 Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains
    2 View Details [74..167] PSI-BLAST 50.69897 Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains
    3 View Details [168..339] deduced N/A No confident structure predictions are available.
    4 View Details [340..415] PSI-BLAST 112.9897 Fyn proto-oncogene tyrosine kinase, SH3 domain; Tyrosine kinase Fyn
    5 View Details [416..502] PSI-BLAST 112.9897 Fyn proto-oncogene tyrosine kinase, SH3 domain; Tyrosine kinase Fyn
    6 View Details [503..791] deduced N/A No confident structure predictions are available.
    7 View Details [792..1063] ORFEUS 9.96 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
    8 View Details [1064..1121] ORFEUS 9.96 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
    9 View Details [1122..1244] ORFEUS 14.72 No description for 1ldvA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  4.67602289179099 bayes_pls_golite062009
  • actin binding
    		•  4.45930345274274 bayes_pls_golite062009
  • actin filament binding
    		•  3.61541643295162 bayes_pls_golite062009
  • binding
    		•  2.92117841029443 bayes_pls_golite062009
  • protein binding
    		•  2.10925438883926 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  4.67602289179099 bayes_pls_golite062009
  • actin binding
    		•  4.45930345274274 bayes_pls_golite062009
  • actin filament binding
    		•  3.61541643295162 bayes_pls_golite062009
  • binding
    		•  2.97936662084105 bayes_pls_golite062009
  • protein binding
    		•  2.16879701585602 bayes_pls_golite062009
  • signal transducer activity
    		•  0.485790902947642 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.485790902947642 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.230308623372106 bayes_pls_golite062009
  • molecular adaptor activity
    		•  0.211510977251932 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle