YRC Public Data Repository - Protein Structure Prediction

Protein:	SLA1
Organism:	Saccharomyces cerevisiae
Length:	1244 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SLA1.

Description	E-value	Query Range	Subject Range
SLA1 - Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; inter... SLA1_YEAST - Actin cytoskeleton-regulatory complex protein SLA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 /...	0.0	[1..1244]	[1..1244]
gi\|16945393 - gi\|16945393\|emb\|CAB97315.2\| related to cytoskeleton assembly control protein SLA1 [Neurospora crassa...	3.0E-96	[3..559]	[2..563]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	3.0E-95	[3..559]	[2..563]
gi\|7329076 - gi\|7329076\|gb\|AAF59903.1\|AF182198_1 intersectin 2 long isoform [Homo sapiens]	3.0E-78	[51..462]	[874..1223]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	1.0E-75	[128..502]	[140..519]
ITN2_MOUSE, ITSN... - Intersectin-2 OS=Mus musculus GN=Itsn2 PE=1 SV=1, (Q9Z0R6) Intersectin 2 (SH3 domain-containing prot...	4.0E-75	[57..462]	[834..1184]

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Predicted Domain #1

Region A:
Residues: [1-73]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVFLGIYRA VYAYEPQTPE ELAIQEDDLL YLLQKSDIDD WWTVKKRVIG SDSEEPVGLV  60
   61 PSTYIEEAPV LKK

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	11.86
Match:	1gbqA
Description:	Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cytoskeletal protein binding	4.67602289179099	bayes_pls_golite062009
actin binding	4.45930345274274	bayes_pls_golite062009
actin filament binding	3.61541643295162	bayes_pls_golite062009
binding	2.92117841029443	bayes_pls_golite062009
protein binding	2.10925438883926	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [74-167]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VRAIYDYEQV QNADEELTFH ENDVFDVFDD KDADWLLVKS TVSNEFGFIP GNYVEPENGS  60
   61 TSKQEQAPAA AEAPAATPAA APASAAVLPT NFLP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.69897
Match:	1azeA_
Description:	Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [168-339]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPQHNDRARM MQSKEDQAPD EDEEGPPPAM PARPTATTET TDATAAAVRS RTRLSYSDND  60
   61 NDDEEDDYYY NSNSNNVGNH EYNTEYHSWN VTEIEGRKKK KAKLSIGNNK INFIPQKGTP 120
  121 HEWSIDKLVS YDNEKKHMFL EFVDPYRSLE LHTGNTTTCE EIMNIIGEYK GA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
cytoskeletal protein binding	4.67602289179099	bayes_pls_golite062009
actin binding	4.45930345274274	bayes_pls_golite062009
actin filament binding	3.61541643295162	bayes_pls_golite062009
binding	2.97936662084105	bayes_pls_golite062009
protein binding	2.16879701585602	bayes_pls_golite062009
signal transducer activity	0.485790902947642	bayes_pls_golite062009
molecular transducer activity	0.485790902947642	bayes_pls_golite062009
protein binding, bridging	0.230308623372106	bayes_pls_golite062009
molecular adaptor activity	0.211510977251932	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [340-415]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRDPGLREVE MASKSKKRGI VQYDFMAESQ DELTIKSGDK VYILDDKKSK DWWMCQLVDS  60
   61 GKSGLVPAQF IEPVRD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	112.9897
Match:	1g83A_
Description:	Fyn proto-oncogene tyrosine kinase, SH3 domain; Tyrosine kinase Fyn
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [416-502]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKHTESTASG IIKSIKKNFT KSPSRSRSRS RSKSNANASW KDDELQNDVV GSAAGKRSRK  60
   61 SSLSSHKKNS SATKDFPNPK KSRLWVD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	112.9897
Match:	1g83A_
Description:	Fyn proto-oncogene tyrosine kinase, SH3 domain; Tyrosine kinase Fyn
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [503-791]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSGTFKVDAE FIGCAKGKIH LHKANGVKIA VAADKLSNED LAYVEKITGF SLEKFKANDG  60
   61 SSSRGTDSRD SERERRRRLK EQEEKERDRR LKERELYELK KARELLDEER SRLQEKELPP 120
  121 IKPPRPTSTT SVPNTTSVPP AESSNNNNSS NKYDWFEFFL NCGVDVSNCQ RYTINFDREQ 180
  181 LTEDMMPDIN NSMLRTLGLR EGDIVRVMKH LDKKFGRENI ASIPTNATGN MFSQPDGSLN 240
  241 VATSPETSLP QQLLPQTTSP AQTAPSTSAE TDDAWTVKPA SKSESNLLS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [792-1063]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKSEFTGSMQ DLLDLQPLEP KKAAASTPEP NLKDLEPVKT GGTTVPAAPV SSAPVSSAPA  60
   61 PLDPFKTGGN NILPLSTGFV MMPMITGGDM LPMQRTGGFV VPQTTFGMQS QVTGGILPVQ 120
  121 KTGNGLIPIS NTGGAMMPQT TFGAAATVLP LQKTGGGLIP IATTGGAQFP QTSFNVQGQQ 180
  181 QLPTGSILPV QKTANGLISA NTGVSMPTVQ RTGGTMIPQT SFGVSQQLTG GAMMTQPQNT 240
  241 GSAMMPQTSF NAVPQITGGA MMPQTSFNAL PQ

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.96
Match:	1jv2B
Description:	Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
Matching Structure (courtesy of the PDB):

Predicted Domain #8

Region A:
Residues: [1064-1121]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTGGAMMPLQ RTGGALNTFN TGGAMIPQTS FSSQAQNTGG FRPQSQFGLT LQKTGGIA

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.96
Match:	1jv2B
Description:	Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
Matching Structure (courtesy of the PDB):

Predicted Domain #9

Region A:
Residues: [1122-1244]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLNQNQFTGG AMNTLSTGGV LQQQQPQTMN TFNTGGVMQE LQMMTTFNTG GAMQQPQMMN  60
   61 TFNTDGIMQQ PQMMNTFNTG GAMQQPQQQA LQNQPTGFGF GNGPQQSRQA NIFNATASNP 120
  121 FGF

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.72
Match:	1ldvA
Description:	No description for 1ldvA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: