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Protein Overview: STE11

General Information:
Name(s) found: STE11 / YLR362W [SGD]
Description(s) found:
Found 20 descriptions.
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  • Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 717 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: activation of MAPKK activity [IDALink to PubMed article][IMPLink to PubMed article]
    MAPKKK cascade involved in osmosensory signaling pathway [IGILink to PubMed article][IMPLink to PubMed article]
    pseudohyphal growth [IMPLink to PubMed article]
    osmosensory signaling pathway via Sho1 osmosensor [IGILink to PubMed article]
    invasive growth in response to glucose limitation [IMPLink to PubMed article]
    signal transduction during filamentous growth [IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article][IMPLink to PubMed article]
    pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMPLink to PubMed article]
    Molecular Function: SAM domain binding [IDALink to PubMed article]
    MAP kinase kinase kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQTQTAEGT DLLIGDEKTN DLPFVQLFLE EIGCTQYLDS FIQCNLVTEE EIKYLDKDIL  60
   61 IALGVNKIGD RLKILRKSKS FQRDKRIEQV NRLKNLMEKV SSLSTATLSM NSELIPEKHC 120
  121 VIFILNDGSA KKVNVNGCFN ADSIKKRLIR RLPHELLATN SNGEVTKMVQ DYDVFVLDYT 180
  181 KNVLHLLYDV ELVTICHAND RVEKNRLIFV SKDQTPSDKA ISTSKKLYLR TLSALSQVGP 240
  241 SSSNLLAQNK GISHNNAEGK LRIDNTEKDR IRQIFNQRPP SEFISTNLAG YFPHTDMKRL 300
  301 QKTMRESFRH SARLSIAQRR PLSAESNNIG DILLKHSNAV DMALLQGLDQ TRLSSKLDTT 360
  361 KIPKLAHKRP EDNDAISNQL ELLSVESGEE EDHDFFGEDS DIVSLPTKIA TPKNWLKGAC 420
  421 IGSGSFGSVY LGMNAHTGEL MAVKQVEIKN NNIGVPTDNN KQANSDENNE QEEQQEKIED 480
  481 VGAVSHPKTN QNIHRKMVDA LQHEMNLLKE LHHENIVTYY GASQEGGNLN IFLEYVPGGS 540
  541 VSSMLNNYGP FEESLITNFT RQILIGVAYL HKKNIIHRDI KGANILIDIK GCVKITDFGI 600
  601 SKKLSPLNKK QNKRASLQGS VFWMSPEVVK QTATTAKADI WSTGCVVIEM FTGKHPFPDF 660
  661 SQMQAIFKIG TNTTPEIPSW ATSEGKNFLR KAFELDYQYR PSALELLQHP WLDAHII

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) STE11 STE50
    View Details (MIPS) Mewes HW, et al. (2004) FUS3 KSS1 STE11 STE5 STE7
    View Details Krogan NJ, et al. (2006) STE11 STE50
    View Details Gavin AC, et al. (2006) STE11 STE50
    View Details Ho Y, et al. (2002) AVO1 BCK2 BEM3 CCT2 CYS4 DIG1 DIG2 GDI1 GUS1 KSS1 NPA3 PIM1 RNH203 RPA135 RPN6 RVB1 SEC4 STE11 STE12 STE7 TEC1 TSC11 VPS21 YPT1 YPT10 YPT31 YPT32 YPT52 YPT53 YPT6 YPT7
    View Details Qiu et al. (2008) FUS3 KSS1 STE11 STE5 STE7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SAM35 STE11 1 Unpublished Fields Lab Data
    View Screen UBC7 STE11 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data STE11 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] PSI-BLAST 8.30103 NMR structure of the Saccharomyces cerevisiae SAM (Sterile Alpha Motif) domain
    2 View Details [107..210] FFAS03 2.33 Protein kinase byr2
    3 View Details [211..717] PSI-BLAST 66.39794 No description for 2h8hA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.32682088990761 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.30659353957398 bayes_pls_golite062009
  • protein binding
    		•  3.17959185034169 bayes_pls_golite062009
  • DNA binding
    		•  2.70497733333132 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.6812146845966 bayes_pls_golite062009
  • transcription factor activity
    		•  2.23426547892206 bayes_pls_golite062009
  • SAM domain binding
    		•  2.00592266938182 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.84254690430222 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.71028970433077 bayes_pls_golite062009
  • chromatin binding
    		•  1.6208950488941 bayes_pls_golite062009
  • transferase activity
    		•  1.32851434738219 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.31446495493975 bayes_pls_golite062009
  • sphingomyelin synthase activity
    		•  0.69814733448699 bayes_pls_golite062009
  • ceramide cholinephosphotransferase activity
    		•  0.69814733448699 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.51354463132415 bayes_pls_golite062009
  • catalytic activity
    		•  0.0451617952658021 bayes_pls_golite062009
    2
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  3.94851994392088 bayes_pls_golite062009
  • tubulin binding
    		•  3.6967716523723 bayes_pls_golite062009
  • microtubule binding
    		•  3.44840963883368 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.02426833898488 bayes_pls_golite062009
  • protein binding
    		•  2.78014377544701 bayes_pls_golite062009
  • binding
    		•  2.70872150536621 bayes_pls_golite062009
  • beta-tubulin binding
    		•  2.27888967812671 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.23822335492051 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.02209816078273 bayes_pls_golite062009
  • DNA binding
    		•  1.8833926783115 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.65143775864899 bayes_pls_golite062009
  • kinase activity
    		•  1.63779463482357 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.53011388333584 bayes_pls_golite062009
  • protein kinase activity
    		•  1.42846875539579 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.35319473648072 bayes_pls_golite062009
  • transferase activity
    		•  1.27638139677762 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.941015766785187 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.67884592236589 bayes_pls_golite062009
  • hydrolase activity
    		•  0.633589926944629 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.624731467637361 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.570146135596153 bayes_pls_golite062009
  • structural molecule activity
    		•  0.562775531859544 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.553626305763168 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.320880597880617 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.266774556233534 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.172760623576326 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.156922202244152 bayes_pls_golite062009
  • enzyme binding
    		•  0.147520546067615 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.110966796471597 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.0437862640556833 bayes_pls_golite062009
    3
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  3.90227691640069 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.41610417530517 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  2.07350687583102 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.93176092222748 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.90354666768303 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • telethonin binding
    		•  1.75733591474207 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.71452519680794 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  1.46046123990071 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.33740973673697 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.27184436658773 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.2323381312171 bayes_pls_golite062009
  • insulin receptor activity
    		•  1.22442673174261 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.14496167267281 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.0383359654359 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  1.00828610859671 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • PTB domain binding
    		•  0.9900774724568 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.925299895386908 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.913893847407112 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.877087652539674 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.872782211382796 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.821371946077904 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • receptor activity
    		•  0.775180603313375 bayes_pls_golite062009
  • phosphoinositide 3-kinase regulator activity
    		•  0.688047400629641 bayes_pls_golite062009
  • insulin binding
    		•  0.614254468447749 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • transporter activity
    		•  0.595111702412257 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.461392047923247 bayes_pls_golite062009
  • kinase binding
    		•  0.443916188551908 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.41384976209545 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.318153468064373 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • protein kinase binding
    		•  0.285611963740145 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • cation channel activity
    		•  0.245400615103891 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  0.242410242748222 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.114318824149111 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0922946791401962 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle