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View Structure Prediction Details

Protein: STE11
Organism: Saccharomyces cerevisiae
Length: 717 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STE11.

Description E-value Query
Range		 Subject
Range
STE11_YEAST - Serine/threonine-protein kinase STE11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ST...
STE11 - Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathwa...
 1.0E-96 [1..717] [1..717]
gi|44980877, gi|... - gi|45185219|ref|NP_982936.1| ABL011Cp [Ashbya gossypii ATCC 10895], gi|44980877|gb|AAS50760.1| ABL01...
gi|44980877 - gi|44980877|gb|AAS50760.1| ABL011Cp [Ashbya gossypii ATCC 10895]
 7.0E-74 [29..712] [12..695]
gi|66797 - gi|66797|pir||TVFVG9 protein-tyrosine kinase (EC 2.7.1.112) yes - avian sarcoma virus Y73
 1.0E-62 [218..706] [4..512]
YES_CHICK - Tyrosine-protein kinase Yes OS=Gallus gallus GN=YES1 PE=1 SV=3
 7.0E-62 [218..706] [12..520]
SRC_RAT - Proto-oncogene tyrosine-protein kinase Src OS=Rattus norvegicus GN=Src PE=1 SV=3
 1.0E-61 [217..704] [6..513]
gi|148231247, gi... - gi|34784684|gb|AAH57707.1| Yes protein [Xenopus laevis], gi|148231247|ref|NP_001079938.1| proto-onco...
 1.0E-61 [222..706] [12..516]
YES_MOUSE - Tyrosine-protein kinase Yes OS=Mus musculus GN=Yes1 PE=1 SV=3
 1.0E-61 [207..706] [1..520]

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Predicted Domain #1
Region A:
Residues: [1-106] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQTQTAEGT DLLIGDEKTN DLPFVQLFLE EIGCTQYLDS FIQCNLVTEE EIKYLDKDIL  60
   61 IALGVNKIGD RLKILRKSKS FQRDKRIEQV NRLKNLMEKV SSLSTA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.30103
Match: 1ow5A
Description: NMR structure of the Saccharomyces cerevisiae SAM (Sterile Alpha Motif) domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.32682088990761 bayes_pls_golite062009
transcription regulator activity 3.30659353957398 bayes_pls_golite062009
protein binding 3.17959185034169 bayes_pls_golite062009
DNA binding 2.70497733333132 bayes_pls_golite062009
nucleic acid binding 2.6812146845966 bayes_pls_golite062009
transcription factor activity 2.23426547892206 bayes_pls_golite062009
SAM domain binding 2.00592266938182 bayes_pls_golite062009
transcription repressor activity 1.84254690430222 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.71028970433077 bayes_pls_golite062009
chromatin binding 1.6208950488941 bayes_pls_golite062009
transferase activity 1.32851434738219 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.31446495493975 bayes_pls_golite062009
sphingomyelin synthase activity 0.69814733448699 bayes_pls_golite062009
ceramide cholinephosphotransferase activity 0.69814733448699 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.51354463132415 bayes_pls_golite062009
catalytic activity 0.0451617952658021 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [107-210] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLSMNSELIP EKHCVIFILN DGSAKKVNVN GCFNADSIKK RLIRRLPHEL LATNSNGEVT  60
   61 KMVQDYDVFV LDYTKNVLHL LYDVELVTIC HANDRVEKNR LIFV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.33
Match: 1k8rB
Description: Protein kinase byr2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 3.94851994392088 bayes_pls_golite062009
tubulin binding 3.6967716523723 bayes_pls_golite062009
microtubule binding 3.44840963883368 bayes_pls_golite062009
cytoskeletal protein binding 3.02426833898488 bayes_pls_golite062009
protein binding 2.78014377544701 bayes_pls_golite062009
binding 2.70872150536621 bayes_pls_golite062009
beta-tubulin binding 2.27888967812671 bayes_pls_golite062009
transcription regulator activity 2.23822335492051 bayes_pls_golite062009
nucleic acid binding 2.02209816078273 bayes_pls_golite062009
DNA binding 1.8833926783115 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.65143775864899 bayes_pls_golite062009
kinase activity 1.63779463482357 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.53011388333584 bayes_pls_golite062009
protein kinase activity 1.42846875539579 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.35319473648072 bayes_pls_golite062009
transferase activity 1.27638139677762 bayes_pls_golite062009
acid-amino acid ligase activity 0.941015766785187 bayes_pls_golite062009
protein serine/threonine kinase activity 0.67884592236589 bayes_pls_golite062009
hydrolase activity 0.633589926944629 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.624731467637361 bayes_pls_golite062009
structural constituent of ribosome 0.570146135596153 bayes_pls_golite062009
structural molecule activity 0.562775531859544 bayes_pls_golite062009
structure-specific DNA binding 0.553626305763168 bayes_pls_golite062009
small conjugating protein ligase activity 0.320880597880617 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.266774556233534 bayes_pls_golite062009
GTPase regulator activity 0.172760623576326 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.156922202244152 bayes_pls_golite062009
enzyme binding 0.147520546067615 bayes_pls_golite062009
single-stranded DNA binding 0.110966796471597 bayes_pls_golite062009
enzyme regulator activity 0.0437862640556833 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [211-717] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKDQTPSDKA ISTSKKLYLR TLSALSQVGP SSSNLLAQNK GISHNNAEGK LRIDNTEKDR  60
   61 IRQIFNQRPP SEFISTNLAG YFPHTDMKRL QKTMRESFRH SARLSIAQRR PLSAESNNIG 120
  121 DILLKHSNAV DMALLQGLDQ TRLSSKLDTT KIPKLAHKRP EDNDAISNQL ELLSVESGEE 180
  181 EDHDFFGEDS DIVSLPTKIA TPKNWLKGAC IGSGSFGSVY LGMNAHTGEL MAVKQVEIKN 240
  241 NNIGVPTDNN KQANSDENNE QEEQQEKIED VGAVSHPKTN QNIHRKMVDA LQHEMNLLKE 300
  301 LHHENIVTYY GASQEGGNLN IFLEYVPGGS VSSMLNNYGP FEESLITNFT RQILIGVAYL 360
  361 HKKNIIHRDI KGANILIDIK GCVKITDFGI SKKLSPLNKK QNKRASLQGS VFWMSPEVVK 420
  421 QTATTAKADI WSTGCVVIEM FTGKHPFPDF SQMQAIFKIG TNTTPEIPSW ATSEGKNFLR 480
  481 KAFELDYQYR PSALELLQHP WLDAHII

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 66.39794
Match: 2h8hA
Description: No description for 2h8hA was found.

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cyclin-dependent protein kinase activity 4.62392503670521 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 3.90227691640069 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
phosphoinositide 3-kinase binding 2.41610417530517 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
fibroblast growth factor receptor activity 2.07350687583102 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
cation transmembrane transporter activity 1.93176092222748 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
ion transmembrane transporter activity 1.90354666768303 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
telethonin binding 1.75733591474207 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.71452519680794 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
fibroblast growth factor binding 1.46046123990071 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
molecular adaptor activity 1.33740973673697 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.27184436658773 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.2323381312171 bayes_pls_golite062009
insulin receptor activity 1.22442673174261 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transcription repressor activity 1.14496167267281 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
fibroblast growth factor 1 binding 1.0383359654359 bayes_pls_golite062009
JUN kinase kinase kinase activity 1.00828610859671 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
PTB domain binding 0.9900774724568 bayes_pls_golite062009
sequence-specific DNA binding 0.925299895386908 bayes_pls_golite062009
transmembrane receptor activity 0.913893847407112 bayes_pls_golite062009
alpha-actinin binding 0.877087652539674 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.872782211382796 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.821371946077904 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
receptor activity 0.775180603313375 bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity 0.688047400629641 bayes_pls_golite062009
insulin binding 0.614254468447749 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
transporter activity 0.595111702412257 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.461392047923247 bayes_pls_golite062009
kinase binding 0.443916188551908 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
transmembrane transporter activity 0.41384976209545 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
structure-specific DNA binding 0.318153468064373 bayes_pls_golite062009
phosphotyrosine binding 0.311079584914389 bayes_pls_golite062009
protein kinase binding 0.285611963740145 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
cation channel activity 0.245400615103891 bayes_pls_golite062009
gamma-tubulin binding 0.242410242748222 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
SH2 domain binding 0.226760162354251 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.114318824149111 bayes_pls_golite062009
substrate-specific transporter activity 0.0922946791401962 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009
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