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Protein Overview: SMD2

General Information:
Name(s) found: SMD2 / YLR275W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 110 amino acids

    Gene Ontology:
    Cellular Component: U4/U6 x U5 tri-snRNP complex [IDALink to PubMed article][IPILink to PubMed article]
    U5 snRNP [IPILink to PubMed article]
    U1 snRNP [IDALink to PubMed articleLink to PubMed article]
    Biological Process: nuclear mRNA splicing, via spliceosome [IPILink to PubMed article]
    Molecular Function: RNA binding [IEA][RCA]
    molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSQIIDRPK HELSRAELEE LEEFEFKHGP MSLINDAMVT RTPVIISLRN NHKIIARVKA  60
   61 FDRHCNMVLE NVKELWTEKK GKNVINRERF ISKLFLRGDS VIVVLKTPVE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRR1 BRR2 CBC2 CUS1 DIB1 HSH155 LEA1 LSM1 LSM2 LSM4 LSM6 LSM7 LSM8 LUC7 MUD1 NAM8 PAT1 PRP11 PRP21 PRP3 PRP31 PRP39 PRP4 PRP40 PRP42 PRP6 PRP8 PRP9 RSE1 SMB1 SMD1 SMD2 SMD3 SME1 SMX3 SNP1 SNU114 SNU23 SNU56 SNU66 SNU71 STO1 YHC1
    View Details Krogan NJ, et al. (2006) AAR2 BRR1 BRR2 CSE1 LUC7 MUD1 NAM8 PRP2 PRP3 PRP31 PRP39 PRP40 PRP42 PRP6 PRP8 RRG7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNU114 SNU56 SNU66 SNU71 TAD2 YDL085C-A YHC1 YJU2 YNL092W
    View Details Gavin AC, et al. (2002) AAR2 AIR2 ASC1 BRR1 BUD31 BUR2 CBC2 CDC33 CDC40 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DCP2 DHH1 DIB1 ECM2 ERB1 GCN2 HRT1 HSH155 HSH49 HTA1 IMG1 ISY1 KAP95 KRS1 LEA1 LIN1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSH4 MSL1 MUD1 NAB3 NAB6 NAM7 NAM8 NOG2 NOP1 NPL3 NRD1 NUG1 NUP60 PAT1 PRP11 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SCP160 SEN1 SGV1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SQS1 SRB2 SRO9 SRP1 STO1 SYF1 THO2 TIF4631 TIF4632 TOS4 UTP21 YEF3 YML6 YRA2
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 CBC2 CDC40 CEF1 CLF1 CUS1 CWC15 CWC2 CWC22 CWC23 DHR2 DIB1 IST3 ISY1 LEA1 LSM2 LSM4 LSM5 LSM7 LSM8 LUC7 MAK5 MSL1 MUD1 MUD2 NAM8 NTC20 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SUB2 SYF2 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CWC2 No Comments Hazbun TR, et al. (2003)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen LSM2 SMD2 2 Uetz P, et al. (2000)
    View Screen LSM4 SMD2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SMD2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] PSI-BLAST 246.450636 D2 core SNRNP protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
    		• 9.36615441177233 bayes_pls_golite062009
  • RNA binding
    		•  5.81718051012035 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.69031444148163 bayes_pls_golite062009
  • mRNA binding
    		•  2.57166143288861 bayes_pls_golite062009
  • binding
    		•  2.44117021254507 bayes_pls_golite062009
  • protein binding
    		•  0.318488892917007 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle