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Protein Overview: HIF1

General Information:
Name(s) found: HIF1 / YLL022C [SGD]
Description(s) found:
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  • gi|74645050|sp|Q12373.1|HIF1_YEAST RecName: Full=HAT1-interacting factor 1 [NCBI NR]
  • gi|6323006|ref|NP_013078.1| Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing; Hif1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S64770 hypothetical protein YLL022c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1360198|emb|CAA97470.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1297009|emb|CAA66169.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • HAT1-interacting factor 1 OS=Saccharomyces cerevisiae GN=HIF1 PE=1 SV=1 [Swiss-Prot]
  • HIF1 Hat1 Interacting Factor 1 [mips]
  • Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing [SGD]
  • HIF1, Chr XII from 99043-100200, reverse complement [yeast_orfs2]
  • Chr XII from 99043-100200, reverse complement [yeastorf3.fasta]
  • Chr XII from 100200-99043, reverse complement [yeastorf5.fasta]
  • >Q12373 (Q12373) Chromosome XII reading frame ORF YLL022C [4932.FASTACCERV.txt]
  • HIF1 SGDID:S0003945, Chr XII from 100200-99043, reverse complement, Uncharacterized ORF [yeastflysequest.fasta]
  • HIF1 SGDID:S0003945, Chr XII from 100200-99043, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Hif1p [Saccharomyces cerevisiae]gi|1297009|emb|CAA66169.1| unnamed protein product [Saccharomyces cerevisiae]gi|1360198|emb|CAA97470.1| unnamed protein product [Saccharomyces cerevisiae]gi|2131727|pir||S64770 hypothetical protein YLL022c - yeast (Sacch [nrdb_11152004_Chlamydomonas]
  • (Q12373) S.cerevisiae chromosome XII reading frame ORF YLL022c (Hypothetical protein L1205) [cerv4932.FASTAC]
  • HIF1 SGDID:S000003945, Chr XII from 100200-99043, reverse complement, Verified ORF, "Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing; Hif1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • HAT1-interacting factor 1 [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • HAT1-interacting factor 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIF1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • HIF1 SGDID:S000003945, Chr XII from 100201-99044, Genome Release 64-1-1, reverse complement, Verified ORF, "Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing" [yeast-030211-contam.fasta]
  • HIF1 SGDID:S000003945, Chr XII from 100201-99044, Genome Release 64-2-1, reverse complement, Verified ORF, "Non-essential component of the HAT-B histone acetyltransferase complex; localized to the nucleus; has a role in telomeric silencing; other members are Hat1p and Hat2p" [20141208_orf_trans.fasta]
  • YLL022C SGDID:S000003945, Chr XII from 100201-99044, Genome Release 64-1-1, reverse complement, Verified ORF, "Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 385 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    histone acetyltransferase complex [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Biological Process: histone acetylation [IDALink to PubMed article][IPILink to PubMed article]
    chromatin silencing at telomere [IGILink to PubMed articleLink to PubMed article]
    nucleosome assembly [IDALink to PubMed article]
    Molecular Function: histone binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLRAEDVLA NGTSRHKVQI DMERQVQIAK DLLAQKKFLE AAKRCQQTLD SLPKDGLLPD  60
   61 PELFTIFAQA VYNMEVQNSG NLFGDALLAG DDGSGSESES EPESDVSNGE EGNENGQTEI 120
  121 PNSRMFQFDQ EEEDLTGDVD SGDSEDSGEG SEEEEENVEK EEERLALHEL ANFSPANEHD 180
  181 DEIEDVSQLR KSGFHIYFEN DLYENALDLL AQALMLLGRP TADGQSLTEN SRLRIGDVYI 240
  241 LMGDIEREAE MFSRAIHHYL KALGYYKTLK PAEQVTEKVI QAEFLVCDAL RWVDQVPAKD 300
  301 KLKRFKHAKA LLEKHMTTRP KDSELQQARL AQIQDDIDEV QENQQHGSKR PLSQPTTSIG 360
  361 FPALEKPLGD FNDLSQLVKK KPRRH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ASF1 HAT1 HAT2 HHF1, HHF2 HHT1, HHT2 HIF1 MAM33 ORC2 POB3 PSH1 PTC4 SPT16 YJR154W
    View Details Krogan NJ, et al. (2006) HIF1 SAP4 SPT2 TRI1
    View Details Gavin AC, et al. (2006) HAT1 HAT2 HHF1, HHF2 HIF1
    View Details Gavin AC, et al. (2002) BDF2 CDC55 CKB1 DYN1 ECM5 GLY1 HAT1 HAT2 HHF1, HHF2 HIF1 HSM3 ICL1 IML1 KAP123 KRE33 LIP2 MAC1 MDN1 MIS1 MSB1 NIP1 NMD5 PFK1 PRO1 PRT1 PSD2 PSE1 PSH1 RPA135 RPC40 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT5 RPT6 RSC3 SAM1 TEL1 TSC11 USO1 UTP20 VTH2 YFR006W YPR077C
    View Details Ho Y, et al. (2002) HAT1 HAT2 HIF1 RTN1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HIF1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..385] ORFEUS 7.63 Dihydropyrimidine dehydrogenase, N-terminal domain; Dihydropyrimidine dehydrogenase, domain 4; Dihydropyrimidine dehydrogenase, domain 3; Dihydropyrimidine dehydrogenase, domain 2; Dihydropyrimidine dehydrogenase, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • N-acetyltransferase activity
    		•  4.5018555446719 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  4.22651890245436 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.92209893972978 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.39383036142893 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.35794141017853 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  3.18633096034095 bayes_pls_golite062009
  • binding
    		•  2.64850159998065 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.36976362065221 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.05265117445838 bayes_pls_golite062009
  • DNA binding
    		•  1.96740629247708 bayes_pls_golite062009
  • protein binding
    		•  1.51322932625387 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.40841220242471 bayes_pls_golite062009
  • transcription factor activity
    		•  1.22524361832616 bayes_pls_golite062009
  • transcription factor binding
    		•  0.447234745044969 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.201108481303385 bayes_pls_golite062009
  • ligase activity
    		•  0.185046836723848 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.0645101607447045 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0514451541233234 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle