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Protein Overview: YGR054W

General Information:
Name(s) found: YGR054W [SGD]
Description(s) found:
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  • gi|6321491|ref|NP_011568.1| Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A; Ygr054wp [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S64348 hypothetical protein YGR054w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1723669|sp|P53235.1|EIF2A_YEAST RecName: Full=Eukaryotic translation initiation factor 2A; Short=eIF-2A [NCBI NR]
  • gi|1323065|emb|CAA97054.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Hypothetical 71.3 kDa protein in SCM4-MUP1 intergenic region - Saccharomyces cerevisiae (Baker's yeast) [Swiss-Prot]
  • Eukaryotic translation initiation factor 2A OS=Saccharomyces cerevisiae GN=YGR054W PE=1 SV=1 [Swiss-Prot]
  • Eukaryotic initiation factor (eIF) 2A [mips]
  • Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A [SGD]
  • YGR054W, Chr VII from 596687-598615 [yeast_orfs2]
  • Chr VII from 596687-598615 [yeastorf3.fasta]
  • Chr VII from 596694-598622 [yeastorf4.fasta]
  • (P53235) Hypothetical 71.3 kDa protein in SCM4-MUP1 intergenic region [4932.FASTACCERV.txt]
  • YGR054W SGDID:S0003286, Chr VII from 596695-598623, Uncharacterized ORF [yeastflysequest.fasta]
  • YGR054W SGDID:S0003286, Chr VII from 596697-598625, Uncharacterized ORF [10112005cervSGD.fasta]
  • Ygr054wp [Saccharomyces cerevisiae]gi|1323065|emb|CAA97054.1| unnamed protein product [Saccharomyces cerevisiae]gi|2131657|pir||S64348 hypothetical protein YGR054w - yeast (Saccharomyces cerevisiae)gi|1723669|sp|P53235|YG22_YEAST Hypothetical 71.3 kDa [nrdb_11152004_Chlamydomonas]
  • YGR054W SGDID:S000003286, Chr VII from 596697-598625, Uncharacterized ORF, "yeast homolog of mammalian eIF2A" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • YGR054W SGDID:S000003286, Chr VII from 596697-598625, Verified ORF, "Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF [yeast-contam.fasta]
  • Hypothetical 71.3 kDa protein in SCM4-MUP1 intergenic region [nr-271106-contam.fasta]
  • Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A; Ygr054wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YGR054W SGDID:S000003286, Chr VII from 596697-598625, Verified ORF, "Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Eukaryotic translation initiation factor 2A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YGR054W PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • YGR054W SGDID:S000003286, Chr VII from 596693-598621, Genome Release 64-1-1, Verified ORF, "Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A" [yeast-030211-contam.fasta]
  • YGR054W SGDID:S000003286, Chr VII from 596693-598621, Genome Release 64-2-1, Verified ORF, "Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A" [20141208_orf_trans.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 642 amino acids

    Gene Ontology:
    Cellular Component: ribosome [IDALink to PubMed article]
    Biological Process: translational initiation [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: translation initiation factor activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSQFFLKTS QDIELFQSYP TFEQSNTNSK DFPVISSVLS PCGRFLALST KENVKVFTGP  60
   61 CLDNVLLTMK LSDVYDLHFS PAGNYLSTWE RASIQDPNHK NVKVWYLNKP FKKDCVSEDI 120
  121 VPAYEYQAKS QSGWFLQFSK LDNYGLRLFK HDLKIVKLSS ANADNFDFQS PFAVLSDDET 180
  181 SQHFTTYLIS PAEHPTICTF TPEKGGKPAQ LIIWALSEGK ITKKIASKTF FKADSCQLKW 240
  241 NPLGNAILCL AITDFDSSNK SYYGENTLYL LSFQGVNGTL GGNSVRVSLT TGPVHDFTWS 300
  301 PTSRQFGVIA GYMPATISFF DLRGNVVHSL PQQAKNTMLF SPSGHYILIA GFGNLQGSVE 360
  361 ILDRLDKFKC VSKFDATNTS VCKWSPGGEF IMTATTSPRL RVDNGVKIWH VSGSLVFVKE 420
  421 FKELLKVDWR SPCNYKTLEN KDEAFFENHI INNWEPLPDS TTSSLDPKIS NKSELQIHSS 480
  481 VQEYISQHPS REASSNGNGS KAKAGGAYKP PHARRTGGGR IVPGVPPGAA KKTIPGLVPG 540
  541 MSANKDANTK NRRRRANKKS SETSPDSTPA PSAPASTNAP TNNKETSPEE KKIRSLLKKL 600
  601 RAIETLKERQ AVGDKLEDTQ VLKIQTEEKV LKDLEKLGWK DE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FUN12 KEM1 NPL3 NSR1 PRP43 RBG1 RPL15A RPL20B RPS11A, RPS11B RPS13 RPS4B, RPS4A RPS8B, RPS8A SBP1 STM1 TSR1 UTP22 YGR054W
    View Details Krogan NJ, et al. (2006) KEM1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 PAT1 PRP24 YGR054W
    View Details Gavin AC, et al. (2002) ADH1 ARP9 BEM2 CBF5 DIM1 ECM16 EMG1 ENP1 HRR25 IMP3 IMP4 KRE33 KRR1 LTV1 MPP10 NOB1 NOC4 NOP1 NOP14 PNO1 RCL1 RIO2 RRP12 SAM1 SLX9 SNF12 SNF2 SNF5 SNF6 SOF1 SWI1 SWI3 SWP82 TSR1 UTP15 UTP20 UTP22 UTP6 UTP7 VPS1 YGR054W
    View Details Ho Y, et al. (2002) HTB2 KRE33 NPL3 YGR054W
    View Details Qiu et al. (2008) FUN12 GCD11 NIP1 PRT1 SUI3 TIF34 TIF35 TIF5 YGR054W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..362] PSI-BLAST 50.0 Tup1, C-terminal domain
    2 View Details [363..497] PSI-BLAST 20.30103 Groucho/tle1, C-terminal domain
    3 View Details [498..642] MSA 3.247996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • structural molecule activity
    		•  5.05435272846365 bayes_pls_golite062009
  • snoRNA binding
    		•  2.69983094099712 bayes_pls_golite062009
  • translation initiation factor activity
    		•  2.29806492548141 bayes_pls_golite062009
  • binding
    		•  1.99637157021613 bayes_pls_golite062009
  • RNA binding
    		•  1.54614730254863 bayes_pls_golite062009
    		• 1.53488375271101 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.24195336789614 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.21914661317312 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • DNA binding
    		•  0.694865434683509 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.523052412917759 bayes_pls_golite062009
  • mRNA binding
    		•  0.273021928390838 bayes_pls_golite062009
  • transcription factor activity
    		•  0.130013114814281 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle