Protein Overview: RET2

General Information:
Name(s) found:	RET2 / YFR051C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|836806\|dbj\|BAA09290.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|14318576\|ref\|NP_116709.1\| Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER; Ret2p [Saccharomyces cerevisiae] [NCBI NR] gi\|1176026\|sp\|P43621.3\|COPD_YEAST RecName: Full=Coatomer subunit delta; AltName: Full=Delta-coat protein; Short=Delta-COP [NCBI NR] pir\|\|S56306 hypothetical protein YFR051c - yeast (Saccharomyces cerevisiae) [NCBI NR] Coatomer subunit delta OS=Saccharomyces cerevisiae GN=RET2 PE=1 SV=3 [Swiss-Prot] RET2 Coatomer complex delta chain [mips] Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER [SGD] RET2, Chr VI from 250151-251791, reverse complement [yeast_orfs2] Chr VI from 250151-251791, reverse complement [yeastorf3.fasta] Chr VI from 251790-250150, reverse complement [yeastorf5.fasta] RET2 SGDID:S0001947, Chr VI from 251790-250150, reverse complement, Verified ORF [yeastflysequest.fasta] Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER [Saccharomyces cerevisiae]gi\|1176026\|sp\|P43621\|COPD_YEAST Coatomer delta subunit (Delta-coat protein) (Delta [nrdb_11152004_Chlamydomonas] RET2 SGDID:S000001947, Chr VI from 251790-250150, reverse complement, Verified ORF, "Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER; Ret2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Coatomer subunit delta (Delta-coat protein) (Delta-COP) [nr-271106-contam.fasta] [chemostatdb.fasta] Coatomer subunit delta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RET2 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] RET2 SGDID:S000001947, Chr VI from 251803-250163, Genome Release 64-1-1, reverse complement, Verified ORF, "Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER" [yeast-030211-contam.fasta] RET2 SGDID:S000001947, Chr VI from 251803-250163, Genome Release 64-2-1, reverse complement, Verified ORF, "Delta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER" [20141208_orf_trans.fasta] TR3894\|c0_g1_i1\|g.2622 ORF TR3894\|c0_g1_i1\|g.2622 TR3894\|c0_g1_i1\|m.2622 type:complete len:547 (+) TR3894\|c0_g1_i1:56-1696(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YFR051C SGDID:S000001947, Chr VI from 251803-250163, Genome Release 64-1-1, reverse complement, Verified ORF, "Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] ID=asmbl_9433\|g.5857 ORF ID=asmbl_9433\|g.5857 ID=asmbl_9433\|m.5857 type:complete len:547 (+) ID=asmbl_9433:54-1694(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	546 amino acids
Gene Ontology:
Cellular Component:	COPI vesicle coat [IMP][ISS]
Biological Process:	ER to Golgi vesicle-mediated transport [IMP] retrograde vesicle-mediated transport, Golgi to ER [IMP]
Molecular Function:	protein binding [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVLAASITT RQGKPLLSRQ FKDLSKDRVL ELLSNFQNLV SEISSDHTFV EDKHVRYVYR  60
   61 PFDNYYIILI TNRQSNIIKD LATLNLFSQT INSYLSSFQD QEIFHNAFEI LSSFDEIVSM 120
  121 GGYKENLSFT QVQTYLSMES HEERIQEIIE RNKEIEATEE RKRRAKEIAR KEHERKHGFM 180
  181 SSNGDYDGAN RFMGSKDPNV TNAINSYYSH ASPAAQQSYL QSSHAAAAEV APVASPMATS 240
  241 QRAGHSATGG MKLGGGAGRR AGAAPRPSAI SSASSGTPPP PEEDVPENNG ILISIKEVIN 300
  301 AEFSRDGTIH SSELKGVLEL RINDHDLSHS NLKLADSIDV RDKSFQFKTH PNIDKQSFLS 360
  361 TKLISLRDKS KAFPANDQSL GVLRWRKVAP AEDDSLIPLT LTTWVSPSES QQGFDVIIEY 420
  421 ESVLETELAD VIFTIPVFPQ EPVDINTESS TCSDAEVVNM DQEMGTSIKI SKIAANDAGA 480
  481 LAFTIEAPYE DALYPMTVSF QESTRDKLAK SFTGMAIQSV VMANDHDQEL PYDVITSLKS 540
  541 DEYLVQ

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		COP1 RET2 RET3 SEC21 SEC26 SEC27 SEC28
View Details	(MIPS) Mewes HW, et al. (2004)		ARF1 COP1 RET2 RET3 SEC21 SEC26 SEC27 SEC28
View Details	Krogan NJ, et al. (2006)		COP1 FCF2 FMP23 LCB5 PIP2 RET2 RET3 SCS2 SEC2 SEC21 SEC26 SEC27 SEC28
View Details	Gavin AC, et al. (2006)		COP1 RET2 RET3 SEC21 SEC26 SEC27 SEC28
View Details	Gavin AC, et al. (2002)		ATG26 BEM2 BUD3 COP1 CYR1 GLO3 GPT2 HRR25 ILV1 IMG1 IMG2 IML1 MHR1 MRH4 MRM1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL16 MRPL17 MRPL19 MRPL20 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL39 MRPL4 MRPL44 MRPL51 MRPL6 MRPL7 MRPL8 NUG1 PGK1 PRP43 RET2 RET3 ROM2 RTC6 SAM1 SCJ1 SEC1 SEC21 SEC26 SEC27 SEC28 SEH1 SIN4 SNF2 SWI3 SYP1 TAF5 TOS1 UTP20 YDR115W YML6
View Details	Ho Y, et al. (2002)		ADR1 ARG4 ATP3 AYR1 COP1 COR1 CPR6 ERG27 GPT2 LIA1 MAE1 OM45 PCT1 PDA1 PET10 PET9 PHO86 PIL1 PRB1 PRE10 PRO3 RET2 RNR2 RTN2 RVS161 SEC18 SEC21 SEC26 SEC27 SEC28 TIF34 TIF35 TPA1 TRP3 YNL181W
View Details	Qiu et al. (2008)		ARF1 COP1 GDA1 GLO3 RET2 RET3 SEC21 SEC24 SEC26 SEC27 SEC28

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ASF1	3829 - low filter	Green EM, et al (2005)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	RET2 and COP1	Huh WK, et al. (2003)
View Data	RET2	Huh WK, et al. (2003)
View Data	RET2 and ANP1	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..85]	PSI-BLAST	101.274545	Sigma2 adaptin (clathrin coat assembly protein AP17)
2	View Details	[86..177]	PSI-BLAST	101.274545	Sigma2 adaptin (clathrin coat assembly protein AP17)
3	View Details	[178..233]	deduced	N/A	No confident structure predictions are available.
4	View Details	[234..546]	PSI-BLAST	77.522879	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; Mu2 adaptin (clathrin coat assembly protein AP50)

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: RET2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: