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View Structure Prediction Details

Protein: RET2
Organism: Saccharomyces cerevisiae
Length: 546 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RET2.

Description E-value Query
Range
Subject
Range
COPD_MOUSE - Coatomer subunit delta OS=Mus musculus GN=Arcn1 PE=1 SV=2
tr|G3I5S7|G3I5S7... - Coatomer subunit delta OS=Cricetulus griseus GN=I79_018833 PE=4 SV=1
482.0 [0..1] [545..1]
ARCN1 - archain 1
gi|114640635 - gi|114640635|ref|XP_508795.2| PREDICTED: archain isoform 2 [Pan troglodytes]
481.0 [0..1] [545..1]
COPD_RAT - Coatomer subunit delta OS=Rattus norvegicus GN=Arcn1 PE=2 SV=1
481.0 [0..1] [545..1]
gi|109108874 - gi|109108874|ref|XP_001098493.1| PREDICTED: similar to archain isoform 2 [Macaca mulatta]
481.0 [0..1] [545..1]
COPD_PONPY - Coatomer subunit delta - Pongo pygmaeus (Orangutan)
COPD_PONAB - Coatomer subunit delta OS=Pongo abelii GN=ARCN1 PE=2 SV=1
480.0 [0..1] [545..1]
gi|114640633 - gi|114640633|ref|XP_001161708.1| PREDICTED: hypothetical protein isoform 1 [Pan troglodytes]
479.0 [0..2] [545..43]
gi|73954685 - gi|73954685|ref|XP_536552.2| PREDICTED: similar to archain isoform 1 [Canis familiaris]
478.0 [0..1] [545..1]

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Predicted Domain #1
Region A:
Residues: [1-85]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVLAASITT RQGKPLLSRQ FKDLSKDRVL ELLSNFQNLV SEISSDHTFV EDKHVRYVYR  60
   61 PFDNYYIILI TNRQSNIIKD LATLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 101.274545
Match: 1gw5S
Description: Sigma2 adaptin (clathrin coat assembly protein AP17)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [86-177]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LFSQTINSYL SSFQDQEIFH NAFEILSSFD EIVSMGGYKE NLSFTQVQTY LSMESHEERI  60
   61 QEIIERNKEI EATEERKRRA KEIARKEHER KH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 101.274545
Match: 1gw5S
Description: Sigma2 adaptin (clathrin coat assembly protein AP17)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [178-233]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFMSSNGDYD GANRFMGSKD PNVTNAINSY YSHASPAAQQ SYLQSSHAAA AEVAPV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [234-546]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASPMATSQRA GHSATGGMKL GGGAGRRAGA APRPSAISSA SSGTPPPPEE DVPENNGILI  60
   61 SIKEVINAEF SRDGTIHSSE LKGVLELRIN DHDLSHSNLK LADSIDVRDK SFQFKTHPNI 120
  121 DKQSFLSTKL ISLRDKSKAF PANDQSLGVL RWRKVAPAED DSLIPLTLTT WVSPSESQQG 180
  181 FDVIIEYESV LETELADVIF TIPVFPQEPV DINTESSTCS DAEVVNMDQE MGTSIKISKI 240
  241 AANDAGALAF TIEAPYEDAL YPMTVSFQES TRDKLAKSFT GMAIQSVVMA NDHDQELPYD 300
  301 VITSLKSDEY LVQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.522879
Match: 1gw5M
Description: Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; Mu2 adaptin (clathrin coat assembly protein AP50)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle