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Protein Overview: GDA1

General Information:
Name(s) found: GDA1 / YEL042W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 518 amino acids

    Gene Ontology:
    Cellular Component: Golgi apparatus [TASLink to PubMed article]
    Biological Process: protein amino acid glycosylation [TASLink to PubMed article]
    Molecular Function: uridine-diphosphatase activity [IDALink to PubMed article]
    guanosine-diphosphatase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPIFRNYRF AIGAFAVIML ILLIKTSSIG PPSIARTVTP NASIPKTPED ISILPVNDEP  60
   61 GYLQDSKTEQ NYPELADAVK SQTSQTCSEE HKYVIMIDAG STGSRVHIYK FDVCTSPPTL 120
  121 LDEKFDMLEP GLSSFDTDSV GAANSLDPLL KVAMNYVPIK ARSCTPVAVK ATAGLRLLGD 180
  181 AKSSKILSAV RDHLEKDYPF PVVEGDGVSI MGGDEEGVFA WITTNYLLGN IGANGPKLPT 240
  241 AAVFDLGGGS TQIVFEPTFP INEKMVDGEH KFDLKFGDEN YTLYQFSHLG YGLKEGRNKV 300
  301 NSVLVENALK DGKILKGDNT KTHQLSSPCL PPKVNATNEK VTLESKETYT IDFIGPDEPS 360
  361 GAQCRFLTDE ILNKDAQCQS PPCSFNGVHQ PSLVRTFKES NDIYIFSYFY DRTRPLGMPL 420
  421 SFTLNELNDL ARIVCKGEET WNSVFSGIAG SLDELESDSH FCLDLSFQVS LLHTGYDIPL 480
  481 QRELRTGKKI ANKEIGWCLG ASLPLLKADN WKCKIQSA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) GDA1 MNN11 RET2 VRG4 YND1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run SEC10 No Comments De Craene, J., et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GDA1 Huh WK, et al. (2003)
    View Data GDA1 and ANP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..277] ORFEUS 7.08 Mammalian type I hexokinase
    2 View Details [278..518] MSA 1.059957 View MSA. No confident structure predictions are available.
    3 View Details [439..518] MSA 6.127995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • substrate-specific transporter activity
    		•  2.6067350860805 bayes_pls_golite062009
  • binding
    		•  1.67810028738512 bayes_pls_golite062009
  • kinase activity
    		•  1.49017495306118 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.41202247176912 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.17094423081025 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  0.918413613159579 bayes_pls_golite062009
  • protein binding
    		•  0.909114722614987 bayes_pls_golite062009
  • peptide binding
    		•  0.512219022453579 bayes_pls_golite062009
  • hexokinase activity
    		•  0.3464071310254 bayes_pls_golite062009
  • catalytic activity
    		•  0.308539563780047 bayes_pls_golite062009
  • protein kinase activity
    		•  0.273427627634136 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.157726298952452 bayes_pls_golite062009
  • glucokinase activity
    		•  0.0827631486617343 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0562867443774764 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.0272188887044016 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle