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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Yku80. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 23 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ACC1
  • endoplasmic reticulum membrane
  • mitochondrion
  • cytosol
  • nuclear envelope organization
  • protein import into nucleus
  • fatty acid biosynthetic process
  • acetyl-CoA carboxylase activity
  • biotin carboxylase activity
  • ADR1
  • nucleus
  • regulation of carbohydrate metabolic process
  • transcription
  • peroxisome organization
  • negative regulation of transcription from RNA polymerase II promoter by glucose
  • transcription factor activity
  • ATP3
  • mitochondrial proton-transporting ATP synthase, central stalk
  • mitochondrion
  • ATP synthesis coupled proton transport
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
  • CCT3
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • COP1
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • CPA2
  • carbamoyl-phosphate synthase complex
  • arginine biosynthetic process
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
  • DEF1
  • nucleus
  • telomere maintenance
  • response to DNA damage stimulus
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • FOL2
  • nucleus
  • cytoplasm
  • folic acid and derivative biosynthetic process
  • GTP cyclohydrolase I activity
  • GAL7
  • cytoplasm
  • galactose catabolic process
  • UTP:galactose-1-phosphate uridylyltransferase activity
  • IDH1
  • mitochondrial matrix
  • mitochondrion
  • mitochondrial nucleoid
  • glutamate biosynthetic process
  • isocitrate metabolic process
  • tricarboxylic acid cycle
  • isocitrate dehydrogenase (NAD+) activity
  • LSC1
  • mitochondrion
  • mitochondrial nucleoid
  • tricarboxylic acid cycle
  • succinyl-CoA metabolic process
  • succinate-CoA ligase (ADP-forming) activity
  • LST8
  • TORC2 complex
  • extrinsic to internal side of plasma membrane
  • Golgi membrane
  • endosome membrane
  • TORC1 complex
  • peripheral to membrane of membrane fraction
  • fungal-type cell wall organization
  • regulation of cell growth
  • signal transduction
  • establishment or maintenance of actin cytoskeleton polarity
  • mitochondria-nucleus signaling pathway
  • transport
  • protein binding
  • protein kinase activator activity
  • LYS12
  • mitochondrion
  • lysine biosynthetic process
  • homoisocitrate dehydrogenase activity
  • PHO86
  • endoplasmic reticulum
  • phosphate transport
  • secretory pathway
  • protein folding
  • molecular_function
  • POR1
  • integral to mitochondrial outer membrane
  • mitochondrion
  • mitochondrial outer membrane
  • ion transport
  • aerobic respiration
  • mitochondrion organization
  • voltage-gated anion channel activity
  • RPN12
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RRP3
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ATP-dependent RNA helicase activity
  • SIP1
  • vacuole
  • AMP-activated protein kinase complex
  • signal transduction
  • regulation of protein complex assembly
  • protein amino acid phosphorylation
  • AMP-activated protein kinase activity
  • SLC1
  • lipid particle
  • sphingolipid biosynthetic process
  • 1-acylglycerol-3-phosphate O-acyltransferase activity
  • STI1
  • cytoplasm
  • protein folding
  • chaperone inhibitor activity
  • chaperone activator activity
  • Hsp90 protein binding
  • Hsp70 protein binding
  • YBT1
  • fungal-type vacuole
  • bile acid and bile salt transport
  • bile acid transmembrane transporter activity
  • ATPase activity, coupled to transmembrane movement of substances
  • YKU80
  • nuclear chromatin
  • nuclear telomeric heterochromatin
  • double-strand break repair via homologous recombination
  • telomere maintenance
  • chromatin assembly or disassembly
  • chromatin silencing
  • double-strand break repair via nonhomologous end joining
  • donor selection
  • DNA binding
  • RNA binding
  • damaged DNA binding
  • YML020W
  • cellular_component
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleoid 3.9386E-3 23 26 2 6292
    mitochondrial nucleoid 3.9386E-3 23 26 2 6292
    carbamoyl-phosphate synthase complex 7.2981E-3 23 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    tricarboxylic acid cycle 1.304E-3 23 15 2 6292
    acetyl-CoA catabolic process 1.304E-3 23 15 2 6292
    carboxylic acid biosynthetic process 1.4569E-3 23 139 4 6292
    organic acid biosynthetic process 1.4569E-3 23 139 4 6292
    acetyl-CoA metabolic process 2.3335E-3 23 20 2 6292
    coenzyme catabolic process 2.3335E-3 23 20 2 6292
    protein folding 2.7151E-3 23 78 3 6292
    cofactor catabolic process 2.8244E-3 23 22 2 6292
    cellular metabolic process 3.1663E-3 23 3033 18 6292
    aerobic respiration 3.2403E-3 23 83 3 6292
    bile acid and bile salt transport 3.6554E-3 23 1 1 6292
    small molecule biosynthetic process 4.5395E-3 23 310 5 6292
    glutamine family amino acid biosynthetic process 4.5606E-3 23 28 2 6292
    generation of precursor metabolites and energy 4.9876E-3 23 195 4 6292
    cellular respiration 5.0293E-3 23 97 3 6292
    metabolic process 5.4977E-3 23 3157 18 6292
    organic acid metabolic process 6.153E-3 23 333 5 6292
    oxoacid metabolic process 6.153E-3 23 333 5 6292
    carboxylic acid metabolic process 6.153E-3 23 333 5 6292
    cellular ketone metabolic process 7.2275E-3 23 346 5 6292
    succinyl-CoA metabolic process 7.2981E-3 23 2 1 6292
    cellular amino acid biosynthetic process 7.8774E-3 23 114 3 6292
    coenzyme metabolic process 9.0699E-3 23 120 3 6292
    ion transport 9.0699E-3 23 120 3 6292
    amine biosynthetic process 9.4897E-3 23 122 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    1-acylglycerol-3-phosphate O-acyltransferase activity 3.6554E-3 23 1 1 6292
    UTP:galactose-1-phosphate uridylyltransferase activity 3.6554E-3 23 1 1 6292
    homoisocitrate dehydrogenase activity 3.6554E-3 23 1 1 6292
    chaperone inhibitor activity 3.6554E-3 23 1 1 6292
    bile acid transmembrane transporter activity 3.6554E-3 23 1 1 6292
    biotin carboxylase activity 3.6554E-3 23 1 1 6292
    GTP cyclohydrolase activity 3.6554E-3 23 1 1 6292
    GTP cyclohydrolase I activity 3.6554E-3 23 1 1 6292
    acylglycerol O-acyltransferase activity 7.2981E-3 23 2 1 6292
    Hsp70 protein binding 7.2981E-3 23 2 1 6292
    succinate-CoA ligase (ADP-forming) activity 7.2981E-3 23 2 1 6292
    succinate-CoA ligase activity 7.2981E-3 23 2 1 6292
    acetyl-CoA carboxylase activity 7.2981E-3 23 2 1 6292
    UTP-monosaccharide-1-phosphate uridylyltransferase activity 7.2981E-3 23 2 1 6292
    isocitrate dehydrogenase (NAD+) activity 7.2981E-3 23 2 1 6292
    Hsp90 protein binding 7.2981E-3 23 2 1 6292
    CoA carboxylase activity 7.2981E-3 23 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle