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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Bud32. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 26 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AAC3
  • mitochondrion
  • mitochondrial inner membrane
  • anaerobic respiration
  • ATP:ADP antiporter activity
  • BUD32
  • nucleus
  • EKC/KEOPS protein complex
  • cytoplasm
  • cellular bud site selection
  • telomere maintenance
  • protein amino acid phosphorylation
  • positive regulation of transcription from RNA polymerase II promoter
  • protein serine/threonine kinase activity
  • CAR2
  • nucleus
  • cytoplasm
  • arginine catabolic process
  • ornithine-oxo-acid transaminase activity
  • CPR6
  • cytoplasm
  • protein folding
  • peptidyl-prolyl cis-trans isomerase activity
  • unfolded protein binding
  • CRM1
  • nucleus
  • mRNA export from nucleus
  • ribosomal large subunit export from nucleus
  • protein export from nucleus
  • protein transmembrane transporter activity
  • DIA4
  • cytoplasm
  • mitochondrion
  • pseudohyphal growth
  • invasive growth in response to glucose limitation
  • aerobic respiration
  • seryl-tRNA aminoacylation
  • serine-tRNA ligase activity
  • GRX3
  • nucleus
  • cellular iron ion homeostasis
  • response to oxidative stress
  • thiol-disulfide exchange intermediate activity
  • GRX4
  • nucleus
  • intracellular
  • cellular iron ion homeostasis
  • response to oxidative stress
  • thiol-disulfide exchange intermediate activity
  • HEF3
  • cytosolic ribosome
  • translational elongation
  • ATPase activity
  • translation elongation factor activity
  • IDP2
  • cytosol
  • glutamate biosynthetic process
  • isocitrate metabolic process
  • isocitrate dehydrogenase (NADP+) activity
  • IMD2
  • cytoplasm
  • GTP biosynthetic process
  • IMP dehydrogenase activity
  • IMD4
  • cytoplasm
  • biological_process
  • IMP dehydrogenase activity
  • KAE1
  • nucleus
  • nuclear chromatin
  • EKC/KEOPS protein complex
  • cytoplasm
  • telomere maintenance
  • positive regulation of transcription from RNA polymerase II promoter
  • chromatin DNA binding
  • NPA3
  • cytoplasm
  • biological_process
  • ATPase activity
  • PHO81
  • nucleus
  • cytoplasm
  • phosphate metabolic process
  • cyclin-dependent protein kinase inhibitor activity
  • RNH202
  • nucleus
  • ribonuclease H2 complex
  • DNA replication
  • ribonuclease H activity
  • RPN1
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • endoplasmic reticulum
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN5
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN6
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPT1
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • SEC18
  • cytoplasm
  • extrinsic to plasma membrane
  • vacuole inheritance
  • ER to Golgi vesicle-mediated transport
  • vacuole fusion, non-autophagic
  • ATPase activity
  • SEC23
  • cytoplasm
  • COPII vesicle coat
  • ER to Golgi vesicle-mediated transport
  • autophagy
  • ER-associated protein catabolic process
  • GTPase activator activity
  • SGO1
  • nucleus
  • spindle pole body
  • kinetochore
  • chromosome, centromeric region
  • mitotic cell cycle spindle assembly checkpoint
  • meiotic sister chromatid segregation
  • mitotic sister chromatid segregation
  • molecular_function
  • TMA29
  • nucleus
  • cytoplasm
  • ribosome
  • metabolic process
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
  • URA7
  • cytosol
  • CTP biosynthetic process
  • phospholipid biosynthetic process
  • pyrimidine base biosynthetic process
  • CTP synthase activity
  • YHR033W
  • cytoplasm
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome regulatory particle 1.9238E-6 26 23 4 6292
    proteasome accessory complex 1.9238E-6 26 23 4 6292
    proteasome complex 3.9412E-5 26 48 4 6292
    proteasome regulatory particle, base subcomplex 5.8072E-4 26 9 2 6292
    EKC/KEOPS protein complex 5.8072E-4 26 9 2 6292
    proteasome regulatory particle, lid subcomplex 7.2406E-4 26 10 2 6292
    intracellular part 1.8099E-3 26 4938 26 6292
    intracellular 2.1987E-3 26 4975 26 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    modification-dependent protein catabolic process 3.7917E-4 26 156 5 6292
    ubiquitin-dependent protein catabolic process 3.7917E-4 26 156 5 6292
    proteolysis involved in cellular protein catabolic process 4.1406E-4 26 159 5 6292
    modification-dependent macromolecule catabolic process 4.7758E-4 26 164 5 6292
    cellular protein catabolic process 5.7859E-4 26 171 5 6292
    proteolysis 8.9075E-4 26 188 5 6292
    protein catabolic process 9.1238E-4 26 189 5 6292
    cellular macromolecule catabolic process 4.0531E-3 26 265 5 6292
    ribonucleoside triphosphate biosynthetic process 4.2858E-3 26 24 2 6292
    nucleoside triphosphate biosynthetic process 5.4091E-3 26 27 2 6292
    cellular catabolic process 5.8925E-3 26 415 6 6292
    ribonucleoside triphosphate metabolic process 6.2251E-3 26 29 2 6292
    macromolecule catabolic process 6.3005E-3 26 294 5 6292
    pyrimidine ribonucleoside triphosphate metabolic process 8.248E-3 26 2 1 6292
    arginine catabolic process 8.248E-3 26 2 1 6292
    CTP metabolic process 8.248E-3 26 2 1 6292
    GTP biosynthetic process 8.248E-3 26 2 1 6292
    pyrimidine ribonucleotide metabolic process 8.248E-3 26 2 1 6292
    pyrimidine ribonucleoside triphosphate biosynthetic process 8.248E-3 26 2 1 6292
    pyrimidine ribonucleotide biosynthetic process 8.248E-3 26 2 1 6292
    seryl-tRNA aminoacylation 8.248E-3 26 2 1 6292
    CTP biosynthetic process 8.248E-3 26 2 1 6292
    anaerobic respiration 8.248E-3 26 2 1 6292
    nucleoside triphosphate metabolic process 8.4934E-3 26 34 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    IMP dehydrogenase activity 4.9138E-5 26 3 2 6292
    thiol-disulfide exchange intermediate activity 4.5282E-4 26 8 2 6292
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3.2166E-3 26 73 3 6292
    ornithine-oxo-acid transaminase activity 4.1322E-3 26 1 1 6292
    oxidoreductase activity, acting on CH-OH group of donors 4.3171E-3 26 81 3 6292
    serine-tRNA ligase activity 8.248E-3 26 2 1 6292
    CTP synthase activity 8.248E-3 26 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle