YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes:	From the published set of protein complexes.
Complex Size:	42 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
ADA2	SLIK (SAGA-like) complex Ada2/Gcn5/Ada3 transcription activator complex SAGA complex	chromatin modification histone acetylation	transcription coactivator activity
ADH1	cytosol	fermentation NADH oxidation ethanol biosynthetic process involved in glucose fermentation to ethanol	alcohol dehydrogenase (NAD) activity
COG3	Golgi transport complex soluble fraction peripheral to membrane of membrane fraction	ER to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport retrograde transport, vesicle recycling within Golgi	protein transporter activity
CSE2	nucleus mediator complex	mitotic sister chromatid segregation transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
ENO2	soluble fraction mitochondrion phosphopyruvate hydratase complex vacuole	gluconeogenesis regulation of vacuole fusion, non-autophagic glycolysis	phosphopyruvate hydratase activity
FAB1	mitochondrion late endosome vacuolar membrane vacuole	vacuole organization late endosome to vacuole transport phospholipid metabolic process negative regulation of transcription from RNA polymerase II promoter by glucose Golgi to vacuole transport	1-phosphatidylinositol-3-phosphate 5-kinase activity phosphatidylinositol-3-phosphate binding
FBA1	cytoplasm mitochondrion cytosol	gluconeogenesis glycolysis	fructose-bisphosphate aldolase activity
GAL11	nucleus mediator complex	telomere maintenance transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
GCN5	SLIK (SAGA-like) complex Ada2/Gcn5/Ada3 transcription activator complex SAGA complex	chromatin modification histone acetylation	histone acetyltransferase activity transcription coactivator activity
MED1	nucleus mediator complex	telomere maintenance transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
MED11	mediator complex	transcription from RNA polymerase II promoter	structural molecule activity RNA polymerase II transcription mediator activity
MED2	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
MED4	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
MED6	mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
MED7	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
MED8	mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
MLP1	nuclear envelope ribonucleoprotein complex nucleoplasm	mRNA export from nucleus protein import into nucleus regulation of transcription	ribonucleoprotein binding
MRPL6	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
NUT1	nucleus mitochondrion	regulation of transcription from RNA polymerase II promoter	molecular_function
NUT2	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
PGD1	nucleus mediator complex	response to drug telomere maintenance transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
PGK1	cytoplasm mitochondrion	gluconeogenesis glycolysis	phosphoglycerate kinase activity
RGR1	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
ROX3	nucleus	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
RPG1	incipient cellular bud site cytoplasm ribosome eukaryotic translation initiation factor 3 complex	translational initiation	translation initiation factor activity
RPO21	mitochondrion DNA-directed RNA polymerase II, core complex	transcription from RNA polymerase II promoter	DNA-directed RNA polymerase activity
SIN4	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
SPT7	SLIK (SAGA-like) complex mitochondrion SAGA complex	chromatin modification protein complex assembly conjugation with cellular fusion histone acetylation	structural molecule activity
SRB2	mediator complex	telomere maintenance transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
SRB4	mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
SRB5	mediator complex	telomere maintenance transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
SRB6	mediator complex	transcription from RNA polymerase II promoter	structural molecule activity RNA polymerase II transcription mediator activity
SRB7	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
SRB8	transcription factor complex	negative regulation of transcription from RNA polymerase II promoter telomere maintenance	RNA polymerase II transcription mediator activity
SRP1	nucleus cytoplasm	nucleocytoplasmic transport	protein transmembrane transporter activity
SSE2	cytoplasm	protein folding protein refolding	adenyl-nucleotide exchange factor activity
SSN2	transcription factor complex	negative regulation of transcription from RNA polymerase II promoter telomere maintenance	general RNA polymerase II transcription factor activity
SSN3	transcription factor complex	negative regulation of transcription from RNA polymerase II promoter telomere maintenance protein amino acid phosphorylation regulation of transcription meiosis	general RNA polymerase II transcription factor activity cyclin-dependent protein kinase activity
SSN8	transcription factor complex	negative regulation of transcription from RNA polymerase II promoter telomere maintenance meiosis	cyclin-dependent protein kinase regulator activity general RNA polymerase II transcription factor activity
TAF6	transcription factor TFIID complex SLIK (SAGA-like) complex SAGA complex	chromatin modification protein amino acid acetylation histone acetylation chromatin organization regulation of transcription involved in G1 phase of mitotic cell cycle transcription initiation from RNA polymerase II promoter	general RNA polymerase II transcription factor activity
TIF1, TIF2	plasma membrane enriched fraction eukaryotic translation initiation factor 4F complex cytoplasm ribosome	regulation of translation translational initiation regulation of translational initiation translation	nucleotide binding nucleic acid binding translation initiation factor activity ATP binding RNA binding ATP-dependent helicase activity helicase activity ATP-dependent RNA helicase activity hydrolase activity
YIL077C	mitochondrion	response to drug	molecular_function

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
mediator complex	9.7128E-42	42	18	18	6292
nucleoplasm	2.0797E-29	42	264	28	6292
nucleoplasm part	1.2309E-28	42	245	27	6292
nuclear lumen	9.372E-23	42	453	28	6292
organelle lumen	1.5386E-19	42	660	29	6292
intracellular organelle lumen	1.5386E-19	42	660	29	6292
membrane-enclosed lumen	8.0384E-19	42	700	29	6292
protein complex	3.5825E-15	42	1137	31	6292
macromolecular complex	1.3035E-12	42	1635	33	6292
nuclear part	2.111E-12	42	1103	28	6292
nucleus	4.2736E-8	42	2041	31	6292
intracellular organelle part	7.587E-7	42	2282	31	6292
organelle part	7.587E-7	42	2282	31	6292
SLIK (SAGA-like) complex	2.9461E-6	42	16	4	6292
intracellular organelle	3.0016E-6	42	4070	40	6292
organelle	3.0289E-6	42	4071	40	6292
membrane-bounded organelle	1.1403E-5	42	3771	38	6292
intracellular membrane-bounded organelle	1.1403E-5	42	3771	38	6292
SAGA complex	1.1502E-5	42	22	4	6292
SAGA-type complex	1.3856E-5	42	23	4	6292
intracellular part	3.6614E-5	42	4938	42	6292
intracellular	5.0162E-5	42	4975	42	6292
transcription factor complex	9.7593E-5	42	71	5	6292
histone acetyltransferase complex	1.9191E-4	42	44	4	6292
Ada2/Gcn5/Ada3 transcription activator complex	4.2953E-4	42	5	2	6292
cell part	1.5537E-3	42	5397	42	6292
cell	1.5782E-3	42	5399	42	6292
plasma membrane enriched fraction	6.6751E-3	42	1	1	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
transcription from RNA polymerase II promoter	6.9703E-25	42	335	27	6292
transcription	2.2019E-20	42	552	28	6292
transcription, DNA-dependent	3.8827E-20	42	503	27	6292
RNA biosynthetic process	5.0443E-20	42	508	27	6292
biosynthetic process	4.6484E-15	42	1602	35	6292
cellular macromolecule biosynthetic process	1.2487E-14	42	1187	31	6292
macromolecule biosynthetic process	1.3111E-14	42	1189	31	6292
cellular biosynthetic process	3.0473E-14	42	1567	34	6292
gene expression	1.1734E-13	42	1283	31	6292
RNA metabolic process	5.4369E-13	42	954	27	6292
primary metabolic process	1.2277E-10	42	2896	39	6292
cellular macromolecule metabolic process	4.5239E-10	42	2285	35	6292
cellular metabolic process	6.6978E-10	42	3033	39	6292
nucleic acid metabolic process	1.0647E-9	42	1415	28	6292
macromolecule metabolic process	1.0761E-9	42	2349	35	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	1.9018E-9	42	1566	29	6292
metabolic process	2.8893E-9	42	3157	39	6292
cellular nitrogen compound metabolic process	3.9618E-8	42	1770	29	6292
nitrogen compound metabolic process	5.2808E-8	42	1791	29	6292
cellular process	6.8234E-6	42	4426	41	6292
chromosome organization	7.5698E-6	42	555	14	6292
negative regulation of transcription from RNA polymerase II promoter	4.3211E-5	42	60	5	6292
histone acetylation	8.6555E-5	42	36	4	6292
anatomical structure homeostasis	8.6562E-5	42	286	9	6292
telomere organization	8.6562E-5	42	286	9	6292
telomere maintenance	8.6562E-5	42	286	9	6292
glucose catabolic process	1.9191E-4	42	44	4	6292
protein amino acid acetylation	2.2847E-4	42	46	4	6292
alcohol biosynthetic process	2.4852E-4	42	47	4	6292
hexose catabolic process	2.9238E-4	42	49	4	6292
monosaccharide catabolic process	4.26E-4	42	54	4	6292
alcohol catabolic process	5.2444E-4	42	57	4	6292
glycolysis	5.7439E-4	42	25	3	6292
protein amino acid acylation	5.9845E-4	42	59	4	6292
regulation of transcription from RNA polymerase II promoter	6.8288E-4	42	228	7	6292
homeostatic process	1.2132E-3	42	408	9	6292
cellular carbohydrate catabolic process	1.2706E-3	42	72	4	6292
gluconeogenesis	1.3129E-3	42	33	3	6292
carbohydrate catabolic process	1.4795E-3	42	75	4	6292
hexose biosynthetic process	1.5604E-3	42	35	3	6292
organelle organization	1.5652E-3	42	1127	16	6292
monosaccharide biosynthetic process	1.9835E-3	42	38	3	6292
regulation of gene expression	2.2262E-3	42	445	9	6292
regulation of macromolecule biosynthetic process	2.6324E-3	42	456	9	6292
covalent chromatin modification	2.6663E-3	42	88	4	6292
histone modification	2.6663E-3	42	88	4	6292
pyruvate metabolic process	3.0287E-3	42	44	3	6292
regulation of cellular biosynthetic process	3.3274E-3	42	472	9	6292
regulation of transcription	3.3738E-3	42	384	8	6292
regulation of biosynthetic process	3.3753E-3	42	473	9	6292
negative regulation of transcription, DNA-dependent	3.6636E-3	42	157	5	6292
negative regulation of RNA metabolic process	3.7648E-3	42	158	5	6292
regulation of macromolecule metabolic process	4.1615E-3	42	488	9	6292
negative regulation of transcription	4.4151E-3	42	164	5	6292
negative regulation of gene expression	4.4151E-3	42	164	5	6292
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	5.4149E-3	42	415	8	6292
regulation of nitrogen compound metabolic process	5.4938E-3	42	416	8	6292
glucose metabolic process	5.7502E-3	42	109	4	6292
negative regulation of macromolecule biosynthetic process	5.8104E-3	42	175	5	6292
regulation of primary metabolic process	5.862E-3	42	514	9	6292
negative regulation of nitrogen compound metabolic process	6.538E-3	42	180	5	6292
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	6.538E-3	42	180	5	6292
regulation of cellular metabolic process	7.6892E-3	42	536	9	6292
negative regulation of biosynthetic process	8.0062E-3	42	189	5	6292
negative regulation of cellular biosynthetic process	8.0062E-3	42	189	5	6292
negative regulation of macromolecule metabolic process	8.5431E-3	42	192	5	6292
regulation of transcription, DNA-dependent	8.7322E-3	42	358	7	6292
regulation of metabolic process	8.7546E-3	42	547	9	6292
hexose metabolic process	9.0231E-3	42	124	4	6292
biological regulation	9.0801E-3	42	1213	15	6292
regulation of biological quality	9.169E-3	42	551	9	6292
small molecule catabolic process	9.2768E-3	42	125	4	6292
regulation of RNA metabolic process	9.3944E-3	42	363	7	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
RNA polymerase II transcription mediator activity	3.1259E-44	42	22	20	6292
general RNA polymerase II transcription factor activity	3.471E-39	42	64	24	6292
RNA polymerase II transcription factor activity	1.0473E-30	42	130	24	6292
transcription regulator activity	3.0946E-23	42	339	26	6292
1-phosphatidylinositol-3-phosphate 5-kinase activity	6.6751E-3	42	1	1	6292
fructose-bisphosphate aldolase activity	6.6751E-3	42	1	1	6292
transcription coactivator activity	8.4298E-3	42	21	2	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis