YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes:	From the published set of protein complexes.
Complex Size:	35 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
BLM10	nucleus proteasome core complex proteasome complex	protein catabolic process proteasome assembly	proteasome activator activity
DAM1	spindle midzone kinetochore microtubule DASH complex spindle condensed nuclear chromosome kinetochore	mitotic spindle organization in nucleus regulation of microtubule polymerization or depolymerization	structural constituent of cytoskeleton
DBP9	nuclear outer membrane nucleolus	ribosome biogenesis ribosomal large subunit assembly	ATP-dependent RNA helicase activity
ECM29	nucleus cytoplasm proteasome complex	protein catabolic process	protein binding
EST3	nucleus telomerase holoenzyme complex	telomere maintenance telomere maintenance via telomerase	telomerase activity
GFA1	cellular_component	cell wall chitin biosynthetic process	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INO4	nucleus	phospholipid biosynthetic process positive regulation of transcription from RNA polymerase II promoter	DNA binding specific RNA polymerase II transcription factor activity
KAP95	cytoplasm nuclear pore	protein import into nucleus nuclear pore complex assembly	protein transmembrane transporter activity
LYS12	mitochondrion	lysine biosynthetic process	homoisocitrate dehydrogenase activity
MDS3	cytoplasm mitochondrion	negative regulation of sporulation resulting in formation of a cellular spore	molecular_function
NUD1	spindle pole body	microtubule nucleation	structural constituent of cytoskeleton
PDA1	mitochondrial pyruvate dehydrogenase complex mitochondrion mitochondrial nucleoid	pyruvate metabolic process	pyruvate dehydrogenase (acetyl-transferring) activity
PDB1	mitochondrial pyruvate dehydrogenase complex mitochondrion mitochondrial nucleoid	pyruvate metabolic process	pyruvate dehydrogenase (acetyl-transferring) activity
PRE10	proteasome core complex, alpha-subunit complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
PRE2	proteasome core complex, beta-subunit complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
PRE3	proteasome core complex, beta-subunit complex	ascospore formation response to stress ubiquitin-dependent protein catabolic process	endopeptidase activity
PRE4	proteasome core complex, beta-subunit complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
PRE5	proteasome core complex, alpha-subunit complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
PRE6	mitochondrion proteasome core complex, alpha-subunit complex cytosol	ubiquitin-dependent protein catabolic process	endopeptidase activity
PRE8	proteasome core complex, alpha-subunit complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
PRE9	proteasome core complex, alpha-subunit complex	filamentous growth ubiquitin-dependent protein catabolic process	endopeptidase activity
PSE1	nucleus cytoplasm	mRNA export from nucleus protein import into nucleus	protein transmembrane transporter activity
PUP3	proteasome core complex, beta-subunit complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
RGR1	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
RPT3	proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RPT5	proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RRP12	nucleus ribosome	maturation of SSU-rRNA ribosome biogenesis	molecular_function
SCL1	mitochondrion proteasome core complex, alpha-subunit complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
SLX9	nucleus nucleolus 90S preribosome preribosome, small subunit precursor	rRNA processing	snoRNA binding
SPA2	polarisome incipient cellular bud site cellular bud tip cellular bud neck mating projection tip	bipolar cellular bud site selection regulation of initiation of mating projection growth pseudohyphal growth actin filament organization regulation of termination of mating projection growth Rho protein signal transduction	cytoskeletal regulatory protein binding
SRP1	nucleus cytoplasm	nucleocytoplasmic transport	protein transmembrane transporter activity
ULP1	nuclear envelope nuclear pore	G2/M transition of mitotic cell cycle protein desumoylation	SUMO-specific protease activity cysteine-type peptidase activity
YFL006W
YMR310C	nucleus	ribosome biogenesis	molecular_function
YRA1	transcription export complex	mRNA export from nucleus	RNA binding

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
proteasome core complex	1.1784E-22	35	16	11	6292
proteasome complex	5.837E-22	35	48	14	6292
proteasome core complex, alpha-subunit complex	1.3164E-13	35	7	6	6292
protein complex	4.999E-9	35	1137	22	6292
macromolecular complex	2.2023E-8	35	1635	25	6292
proteasome core complex, beta-subunit complex	2.7758E-8	35	7	4	6292
pyruvate dehydrogenase complex	4.4468E-4	35	6	2	6292
mitochondrial pyruvate dehydrogenase complex	4.4468E-4	35	6	2	6292
proteasome regulatory particle, base subcomplex	1.0561E-3	35	9	2	6292
proteasome accessory complex	7.0682E-3	35	23	2	6292
proteasome regulatory particle	7.0682E-3	35	23	2	6292
nucleoid	8.9854E-3	35	26	2	6292
mitochondrial nucleoid	8.9854E-3	35	26	2	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
protein catabolic process	4.0219E-13	35	189	14	6292
modification-dependent protein catabolic process	1.8023E-11	35	156	12	6292
ubiquitin-dependent protein catabolic process	1.8023E-11	35	156	12	6292
proteolysis involved in cellular protein catabolic process	2.2607E-11	35	159	12	6292
modification-dependent macromolecule catabolic process	3.265E-11	35	164	12	6292
cellular protein catabolic process	5.3544E-11	35	171	12	6292
proteolysis	1.6329E-10	35	188	12	6292
macromolecule catabolic process	1.6653E-10	35	294	14	6292
cellular macromolecule catabolic process	8.5414E-9	35	265	12	6292
catabolic process	1.4739E-7	35	496	14	6292
cellular catabolic process	1.1999E-6	35	415	12	6292
cellular process	5.3209E-4	35	4426	33	6292
protein metabolic process	5.6021E-4	35	1136	15	6292
regulation of developmental process	1.6022E-3	35	11	2	6292
regulation of anatomical structure morphogenesis	1.6022E-3	35	11	2	6292
cellular protein metabolic process	3.5402E-3	35	1074	13	6292
macromolecule metabolic process	5.2636E-3	35	2349	21	6292
nuclear transport	5.5479E-3	35	130	4	6292
nucleocytoplasmic transport	5.5479E-3	35	130	4	6292
pore complex assembly	5.5626E-3	35	1	1	6292
nuclear pore complex assembly	5.5626E-3	35	1	1	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
endopeptidase activity	3.1203E-17	35	54	12	6292
peptidase activity, acting on L-amino acid peptides	1.025E-15	35	95	13	6292
peptidase activity	1.0877E-11	35	192	13	6292
macromolecule transmembrane transporter activity	1.2949E-5	35	9	3	6292
protein transmembrane transporter activity	1.2949E-5	35	9	3	6292
pyruvate dehydrogenase (acetyl-transferring) activity	1.7912E-4	35	4	2	6292
pyruvate dehydrogenase activity	1.7912E-4	35	4	2	6292
hydrolase activity	1.9133E-4	35	911	14	6292
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	2.9749E-4	35	5	2	6292
protein transporter activity	3.9468E-3	35	58	3	6292
homoisocitrate dehydrogenase activity	5.5626E-3	35	1	1	6292
glutamine-fructose-6-phosphate transaminase (isomerizing) activity	5.5626E-3	35	1	1	6292
oxidoreductase activity, acting on the aldehyde or oxo group of donors	8.3231E-3	35	25	2	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis