YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes:	From the published set of core protein complex predictions.
Complex Size:	32 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
ADA2	SLIK (SAGA-like) complex Ada2/Gcn5/Ada3 transcription activator complex SAGA complex	chromatin modification histone acetylation	transcription coactivator activity
AHC1	Ada2/Gcn5/Ada3 transcription activator complex	histone acetylation	histone acetyltransferase activity
AHC2	nucleus cytoplasm	telomere maintenance	molecular_function
FMP40	mitochondrion	biological_process	molecular_function
GCN5	SLIK (SAGA-like) complex Ada2/Gcn5/Ada3 transcription activator complex SAGA complex	chromatin modification histone acetylation	histone acetyltransferase activity transcription coactivator activity
HFI1	SLIK (SAGA-like) complex Ada2/Gcn5/Ada3 transcription activator complex SAGA complex	chromatin modification telomere maintenance transcription from RNA polymerase II promoter histone acetylation	transcription cofactor activity transcription coactivator activity
MSS4	plasma membrane	ascospore formation actin cytoskeleton organization	1-phosphatidylinositol-4-phosphate 5-kinase activity
NGG1	SLIK (SAGA-like) complex Ada2/Gcn5/Ada3 transcription activator complex SAGA complex	chromatin modification response to drug histone acetylation	transcription cofactor activity
PDR15	integral to membrane	transport	ATPase activity, coupled to transmembrane movement of substances
RAD59	nucleus	double-strand break repair via break-induced replication double-strand break repair via single-strand annealing telomere maintenance via recombination	protein binding DNA strand annealing activity
REV3	mitochondrion zeta DNA polymerase complex	mutagenesis DNA repair	nucleotide binding nucleic acid binding DNA binding DNA-directed DNA polymerase activity nucleotidyltransferase activity metal ion binding transferase activity
SGF11	nucleus SAGA complex	regulation of transcription from RNA polymerase II promoter histone deubiquitination	molecular_function
SGF29	SAGA complex	histone acetylation	molecular_function
SGF73	SLIK (SAGA-like) complex SAGA complex	chromatin modification histone acetylation	histone acetyltransferase activity structural molecule activity
SNL1	nuclear envelope endoplasmic reticulum membrane mitochondrion membrane	nuclear pore organization protein folding	chaperone regulator activity
SPT20	SLIK (SAGA-like) complex SAGA complex	chromatin modification histone acetylation	transcription cofactor activity
SPT3	SLIK (SAGA-like) complex SAGA complex	chromatin modification ascospore formation conjugation with cellular fusion pseudohyphal growth histone acetylation invasive growth in response to glucose limitation	transcription cofactor activity
SPT7	SLIK (SAGA-like) complex mitochondrion SAGA complex	chromatin modification protein complex assembly conjugation with cellular fusion histone acetylation	structural molecule activity
SPT8	nucleus SAGA complex	negative regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter	transcription cofactor activity TATA-binding protein binding
TAF1	transcription factor TFIID complex	protein amino acid phosphorylation regulation of transcription involved in G1 phase of mitotic cell cycle transcription initiation from RNA polymerase II promoter	histone acetyltransferase activity general RNA polymerase II transcription factor activity protein serine/threonine kinase activity
TAF10	transcription factor TFIID complex SLIK (SAGA-like) complex SAGA complex	chromatin modification protein amino acid acetylation histone acetylation chromatin organization regulation of transcription involved in G1 phase of mitotic cell cycle transcription initiation from RNA polymerase II promoter	general RNA polymerase II transcription factor activity
TAF11	transcription factor TFIID complex	regulation of transcription involved in G1 phase of mitotic cell cycle transcription initiation from RNA polymerase II promoter	general RNA polymerase II transcription factor activity
TAF12	transcription factor TFIID complex SLIK (SAGA-like) complex SAGA complex	chromatin modification protein amino acid acetylation histone acetylation chromatin organization regulation of transcription involved in G1 phase of mitotic cell cycle transcription initiation from RNA polymerase II promoter	general RNA polymerase II transcription factor activity
TAF13	nucleus transcription factor TFIID complex	regulation of transcription involved in G1 phase of mitotic cell cycle transcription initiation from RNA polymerase II promoter	general RNA polymerase II transcription factor activity
TAF3	transcription factor TFIID complex	regulation of transcription involved in G1 phase of mitotic cell cycle transcription initiation from RNA polymerase II promoter	general RNA polymerase II transcription factor activity
TAF4	transcription factor TFIID complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription factor activity
TAF5	transcription factor TFIID complex SLIK (SAGA-like) complex SAGA complex	chromatin modification protein amino acid acetylation histone acetylation chromatin organization regulation of transcription involved in G1 phase of mitotic cell cycle transcription initiation from RNA polymerase II promoter	general RNA polymerase II transcription factor activity
TAF6	transcription factor TFIID complex SLIK (SAGA-like) complex SAGA complex	chromatin modification protein amino acid acetylation histone acetylation chromatin organization regulation of transcription involved in G1 phase of mitotic cell cycle transcription initiation from RNA polymerase II promoter	general RNA polymerase II transcription factor activity
TAF7	nucleus transcription factor TFIID complex	regulation of transcription involved in G1 phase of mitotic cell cycle transcription initiation from RNA polymerase II promoter	general RNA polymerase II transcription factor activity
TAF9	transcription factor TFIID complex SLIK (SAGA-like) complex SAGA complex	chromatin modification protein amino acid acetylation histone acetylation chromatin organization regulation of transcription involved in G1 phase of mitotic cell cycle transcription initiation from RNA polymerase II promoter	general RNA polymerase II transcription factor activity
UBP8	SAGA complex	protein deubiquitination	ubiquitin-specific protease activity
YMR007W

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
SAGA complex	1.4102E-37	32	22	17	6292
SAGA-type complex	5.3934E-37	32	23	17	6292
histone acetyltransferase complex	1.2614E-32	32	44	18	6292
SLIK (SAGA-like) complex	5.0203E-29	32	16	13	6292
nucleoplasm part	3.8434E-28	32	245	24	6292
nucleoplasm	2.4563E-27	32	264	24	6292
transcription factor TFIID complex	1.1449E-23	32	15	11	6292
nuclear lumen	1.2912E-21	32	453	24	6292
organelle lumen	9.9838E-18	32	660	24	6292
intracellular organelle lumen	9.9838E-18	32	660	24	6292
membrane-enclosed lumen	3.9772E-17	32	700	24	6292
DNA-directed RNA polymerase II, holoenzyme	1.1008E-15	32	56	11	6292
transcription factor complex	1.8072E-14	32	71	11	6292
nuclear part	9.4216E-14	32	1103	25	6292
protein complex	1.9422E-13	32	1137	25	6292
Ada2/Gcn5/Ada3 transcription activator complex	2.4543E-12	32	5	5	6292
macromolecular complex	9.4299E-10	32	1635	25	6292
nucleus	1.7655E-9	32	2041	27	6292
intracellular organelle part	2.2808E-7	32	2282	26	6292
organelle part	2.2808E-7	32	2282	26	6292
membrane-bounded organelle	1.2848E-4	32	3771	29	6292
intracellular membrane-bounded organelle	1.2848E-4	32	3771	29	6292
intracellular organelle	8.3915E-4	32	4070	29	6292
organelle	8.4414E-4	32	4071	29	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
histone acetylation	4.14E-27	32	36	15	6292
protein amino acid acetylation	3.7092E-25	32	46	15	6292
protein amino acid acylation	2.7972E-23	32	59	15	6292
covalent chromatin modification	2.5847E-22	32	88	16	6292
histone modification	2.5847E-22	32	88	16	6292
regulation of transcription involved in G1 phase of mitotic cell cycle	2.3962E-21	32	14	10	6292
chromatin modification	1.3522E-17	32	168	16	6292
G1 phase	1.9374E-17	32	27	10	6292
G1 phase of mitotic cell cycle	1.9374E-17	32	27	10	6292
chromatin organization	2.9194E-16	32	203	16	6292
post-translational protein modification	5.5603E-15	32	357	18	6292
transcription initiation from RNA polymerase II promoter	1.1154E-14	32	47	10	6292
transcription initiation	1.0851E-13	32	58	10	6292
protein modification process	1.8994E-12	32	499	18	6292
chromosome organization	1.1702E-11	32	555	18	6292
macromolecule modification	1.7867E-11	32	569	18	6292
interphase of mitotic cell cycle	2.3072E-11	32	97	10	6292
interphase	2.3072E-11	32	97	10	6292
protein complex biogenesis	1.175E-10	32	155	11	6292
protein complex assembly	1.175E-10	32	155	11	6292
transcription from RNA polymerase II promoter	2.2168E-10	32	335	14	6292
cellular component organization	4.4317E-10	32	1582	25	6292
regulation of transcription from RNA polymerase II promoter	4.5713E-10	32	228	12	6292
cellular macromolecule metabolic process	2.8218E-9	32	2285	28	6292
macromolecule metabolic process	5.781E-9	32	2349	28	6292
organelle organization	2.5046E-8	32	1127	20	6292
transcription, DNA-dependent	4.4715E-8	32	503	14	6292
RNA biosynthetic process	5.0717E-8	32	508	14	6292
macromolecular complex assembly	6.4774E-8	32	281	11	6292
macromolecular complex subunit organization	7.455E-8	32	357	12	6292
regulation of transcription, DNA-dependent	7.6898E-8	32	358	12	6292
cellular protein metabolic process	8.2154E-8	32	1074	19	6292
regulation of RNA metabolic process	8.9667E-8	32	363	12	6292
transcription	1.4503E-7	32	552	14	6292
regulation of transcription	1.6672E-7	32	384	12	6292
protein metabolic process	2.0822E-7	32	1136	19	6292
mitotic cell cycle	2.9403E-7	32	255	10	6292
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	3.8955E-7	32	415	12	6292
regulation of nitrogen compound metabolic process	3.9988E-7	32	416	12	6292
regulation of gene expression	8.2895E-7	32	445	12	6292
regulation of macromolecule biosynthetic process	1.0776E-6	32	456	12	6292
primary metabolic process	1.1951E-6	32	2896	28	6292
regulation of cellular biosynthetic process	1.5583E-6	32	472	12	6292
cellular component assembly	1.5661E-6	32	385	11	6292
regulation of biosynthetic process	1.5939E-6	32	473	12	6292
regulation of macromolecule metabolic process	2.2216E-6	32	488	12	6292
cellular metabolic process	3.7615E-6	32	3033	28	6292
regulation of primary metabolic process	3.8437E-6	32	514	12	6292
regulation of cellular metabolic process	5.9621E-6	32	536	12	6292
regulation of metabolic process	7.3669E-6	32	547	12	6292
metabolic process	1.005E-5	32	3157	28	6292
cell cycle phase	1.0147E-5	32	376	10	6292
biological regulation	8.677E-5	32	1213	16	6292
RNA metabolic process	9.9783E-5	32	954	14	6292
cell cycle process	1.0064E-4	32	490	10	6292
nucleic acid metabolic process	1.4928E-4	32	1415	17	6292
cell cycle	1.7935E-4	32	525	10	6292
regulation of cellular process	3.1029E-4	32	796	12	6292
cellular component biogenesis	3.9596E-4	32	694	11	6292
regulation of biological process	4.2995E-4	32	824	12	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	5.4925E-4	32	1566	17	6292
cellular macromolecule biosynthetic process	1.0485E-3	32	1187	14	6292
macromolecule biosynthetic process	1.0668E-3	32	1189	14	6292
gene expression	2.3059E-3	32	1283	14	6292
cellular nitrogen compound metabolic process	2.4432E-3	32	1770	17	6292
nitrogen compound metabolic process	2.8061E-3	32	1791	17	6292
protein deubiquitination	4.9546E-3	32	21	2	6292
histone deubiquitination	5.0858E-3	32	1	1	6292
cellular process	6.0296E-3	32	4426	29	6292
protein modification by small protein removal	9.3395E-3	32	29	2	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
transcription regulator activity	2.2275E-15	32	339	18	6292
general RNA polymerase II transcription factor activity	3.0899E-13	32	64	10	6292
RNA polymerase II transcription factor activity	1.7079E-11	32	130	11	6292
transcription cofactor activity	7.2435E-10	32	40	7	6292
transcription factor binding	1.2389E-9	32	43	7	6292
lysine N-acetyltransferase activity	1.2523E-6	32	17	4	6292
histone acetyltransferase activity	1.2523E-6	32	17	4	6292
N-acetyltransferase activity	2.0337E-5	32	33	4	6292
N-acyltransferase activity	3.6038E-5	32	38	4	6292
acetyltransferase activity	1.0773E-4	32	50	4	6292
transcription coactivator activity	1.4937E-4	32	21	3	6292
transferase activity, transferring acyl groups other than amino-acyl groups	1.1253E-3	32	92	4	6292
acyltransferase activity	1.1253E-3	32	92	4	6292
transferase activity, transferring acyl groups	1.9703E-3	32	107	4	6292
transcription activator activity	3.521E-3	32	61	3	6292
1-phosphatidylinositol-4-phosphate 5-kinase activity	5.0858E-3	32	1	1	6292
protein binding	9.7689E-3	32	612	8	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis