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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 440.30.10
Complex Size: 37 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AAR2
  • U5 snRNP
  • assembly of spliceosomal tri-snRNP
  • molecular_function
  • BRR1
  • small nuclear ribonucleoprotein complex
  • spliceosome assembly
  • RNA binding
  • BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
  • ATP-dependent RNA helicase activity
  • CBC2
  • commitment complex
  • nuclear cap binding complex
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
  • RNA cap binding
  • CDC40
  • spliceosomal complex
  • nuclear mRNA branch site recognition
  • nuclear mRNA 3'-splice site recognition
  • second spliceosomal transesterification activity
  • CWC15
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • CWC2
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • CWC22
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • CWC23
  • spliceosomal complex
  • biological_process
  • molecular_function
  • DHR2
  • nucleolus
  • ribosome biogenesis
  • RNA helicase activity
  • LSM4
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • MAK5
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • MUD2
  • commitment complex
  • RNA splicing
  • nuclear mRNA branch site recognition
  • mRNA processing
  • mRNA binding
  • PRP16
  • spliceosomal complex
  • RNA splicing
  • generation of catalytic spliceosome for second transesterification step
  • mRNA processing
  • ATP-dependent RNA helicase activity
  • PRP18
  • U4/U6 x U5 tri-snRNP complex
  • spliceosomal complex
  • generation of catalytic spliceosome for second transesterification step
  • nuclear mRNA splicing, via spliceosome
  • second spliceosomal transesterification activity
  • PRP2
  • nucleus
  • spliceosomal complex
  • RNA splicing
  • generation of catalytic spliceosome for first transesterification step
  • mRNA processing
  • ATP-dependent RNA helicase activity
  • PRP22
  • spliceosomal complex
  • generation of catalytic spliceosome for second transesterification step
  • second spliceosomal transesterification activity
  • ATP-dependent RNA helicase activity
  • PRP24
  • U6 snRNP
  • spliceosome assembly
  • assembly of spliceosomal tri-snRNP
  • nucleic acid binding
  • nucleotide binding
  • U6 snRNA binding
  • RNA binding
  • snRNA binding
  • PRP28
  • U5 snRNP
  • spliceosomal complex
  • RNA splicing
  • mRNA processing
  • cis assembly of pre-catalytic spliceosome
  • ATP-dependent RNA helicase activity
  • PRP31
  • mitochondrion
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • PRP38
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP39
  • commitment complex
  • U1 snRNP
  • nuclear mRNA 5'-splice site recognition
  • pre-mRNA 5'-splice site binding
  • PRP4
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP40
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PRP43
  • mitochondrion
  • spliceosomal complex
  • nuclear outer membrane
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • processing of 27S pre-rRNA
  • ATP-dependent RNA helicase activity
  • PRP5
  • spliceosomal complex
  • RNA splicing
  • nuclear mRNA branch site recognition
  • mRNA processing
  • ATP-dependent RNA helicase activity
  • PRP6
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • binding
  • molecular_function
  • PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
  • U5 snRNA binding
  • SLU7
  • spliceosomal complex
  • generation of catalytic spliceosome for second transesterification step
  • second spliceosomal transesterification activity
  • SMD1
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SMD3
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SME1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SNP1
  • commitment complex
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • U1 snRNA binding
  • mRNA binding
  • SPP2
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • SPP381
  • U4/U6 x U5 tri-snRNP complex
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • protein binding
  • STO1
  • commitment complex
  • nuclear cap binding complex
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • YHC1
  • commitment complex
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    spliceosomal complex 1.1389E-40 37 45 22 6292
    ribonucleoprotein complex 1.6187E-36 37 514 35 6292
    small nuclear ribonucleoprotein complex 5.0883E-32 37 63 20 6292
    nuclear part 6.3241E-29 37 1103 37 6292
    U4/U6 x U5 tri-snRNP complex 4.8852E-20 37 32 12 6292
    nucleus 6.4938E-19 37 2041 37 6292
    macromolecular complex 9.391E-19 37 1635 35 6292
    intracellular organelle part 4.1795E-17 37 2282 37 6292
    organelle part 4.1795E-17 37 2282 37 6292
    U2-type spliceosomal complex 3.0995E-16 37 12 8 6292
    commitment complex 3.0995E-16 37 12 8 6292
    U5 snRNP 4.4445E-13 37 14 7 6292
    U1 snRNP 2.4871E-12 37 17 7 6292
    membrane-bounded organelle 5.5312E-9 37 3771 37 6292
    intracellular membrane-bounded organelle 5.5312E-9 37 3771 37 6292
    intracellular organelle 9.4317E-8 37 4070 37 6292
    organelle 9.5182E-8 37 4071 37 6292
    nuclear cap binding complex 1.0058E-4 37 3 2 6292
    intracellular part 1.2404E-4 37 4938 37 6292
    intracellular 1.6366E-4 37 4975 37 6292
    RNA cap binding complex 4.9732E-4 37 6 2 6292
    U6 snRNP 1.79E-3 37 11 2 6292
    cell part 3.3636E-3 37 5397 37 6292
    cell 3.4102E-3 37 5399 37 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 5.1591E-58 37 99 33 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 7.6953E-58 37 100 33 6292
    RNA splicing, via transesterification reactions 1.1102E-56 37 107 33 6292
    RNA splicing 3.5316E-53 37 132 33 6292
    mRNA processing 1.7856E-50 37 156 33 6292
    mRNA metabolic process 1.4052E-45 37 213 33 6292
    RNA processing 2.8184E-41 37 380 35 6292
    RNA metabolic process 6.0699E-27 37 954 35 6292
    ribonucleoprotein complex assembly 1.7099E-22 37 92 17 6292
    gene expression 2.0159E-22 37 1283 35 6292
    nucleic acid metabolic process 6.1624E-21 37 1415 35 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.1015E-19 37 1566 35 6292
    cellular nitrogen compound metabolic process 1.4665E-17 37 1770 35 6292
    nitrogen compound metabolic process 2.205E-17 37 1791 35 6292
    cellular macromolecular complex assembly 3.1576E-17 37 182 17 6292
    spliceosomal conformational changes to generate catalytic conformation 4.7607E-15 37 9 7 6292
    cellular macromolecular complex subunit organization 1.2653E-14 37 259 17 6292
    ribonucleoprotein complex biogenesis 2.1516E-14 37 374 19 6292
    spliceosome assembly 2.6731E-14 37 18 8 6292
    macromolecular complex assembly 4.9303E-14 37 281 17 6292
    cellular macromolecule metabolic process 9.5671E-14 37 2285 35 6292
    macromolecule metabolic process 2.457E-13 37 2349 35 6292
    macromolecular complex subunit organization 2.5274E-12 37 357 17 6292
    cellular component assembly 8.5895E-12 37 385 17 6292
    primary metabolic process 2.9501E-10 37 2896 35 6292
    cellular component biogenesis 1.3127E-9 37 694 19 6292
    cellular metabolic process 1.3886E-9 37 3033 35 6292
    generation of catalytic spliceosome for second transesterification step 5.0403E-9 37 5 4 6292
    metabolic process 5.2863E-9 37 3157 35 6292
    nuclear mRNA branch site recognition 1.8725E-7 37 3 3 6292
    mRNA splice site selection 3.6996E-6 37 6 3 6292
    nuclear mRNA 3'-splice site recognition 3.3651E-5 37 2 2 6292
    spliceosomal snRNP assembly 3.3651E-5 37 2 2 6292
    assembly of spliceosomal tri-snRNP 3.3651E-5 37 2 2 6292
    cellular process 3.5579E-5 37 4426 36 6292
    nuclear mRNA cis splicing, via spliceosome 1.0058E-4 37 3 2 6292
    generation of catalytic spliceosome for first transesterification step 1.0058E-4 37 3 2 6292
    cellular component organization 5.2963E-4 37 1582 19 6292
    regulation of hormone levels 5.8805E-3 37 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 5.8805E-3 37 1 1 6292
    nuclear mRNA 5'-splice site recognition 5.8805E-3 37 1 1 6292
    auxin biosynthetic process 5.8805E-3 37 1 1 6292
    auxin metabolic process 5.8805E-3 37 1 1 6292
    hormone metabolic process 5.8805E-3 37 1 1 6292
    hormone biosynthetic process 5.8805E-3 37 1 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA helicase activity 1.1469E-12 37 42 9 6292
    ATP-dependent RNA helicase activity 1.8221E-12 37 28 8 6292
    RNA-dependent ATPase activity 2.506E-12 37 29 8 6292
    ATP-dependent helicase activity 2.0372E-10 37 48 8 6292
    purine NTP-dependent helicase activity 2.0372E-10 37 48 8 6292
    RNA binding 6.6896E-10 37 367 15 6292
    helicase activity 7.1635E-10 37 83 9 6292
    mRNA binding 7.9748E-10 37 35 7 6292
    second spliceosomal transesterification activity 3.4986E-8 37 7 4 6292
    ATPase activity, coupled 1.768E-6 37 149 8 6292
    snRNA binding 1.8573E-6 37 5 3 6292
    nucleic acid binding 2.0234E-6 37 666 15 6292
    ATPase activity 2.3365E-5 37 211 8 6292
    nucleoside-triphosphatase activity 8.86E-5 37 329 9 6292
    hydrolase activity, acting on acid anhydrides 1.5228E-4 37 353 9 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.5228E-4 37 353 9 6292
    pyrophosphatase activity 1.5228E-4 37 353 9 6292
    binding 4.4508E-4 37 1294 17 6292
    pre-mRNA 5'-splice site binding 5.8805E-3 37 1 1 6292
    U6 snRNA binding 5.8805E-3 37 1 1 6292
    U1 snRNA binding 5.8805E-3 37 1 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle