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The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation. The cellular process by which a complex containing RNA and proteins is synthesized, aggregates, and bonds together. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11). The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
Acc: GO:0000388
Aspect: Biological Process
Desc: Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11).
Synonyms:
  • 3'-splice site cleavage, exon ligation
  • GO:0000397
  • GO:0000396
  • spliceosomal B2 complex formation
  • spliceosomal A1 complex biosynthesis
  • spliceosomal A1 complex formation
  • U12-type spliceosome conformational change to release U4atac and U11
  • U2-type spliceosome conformational change to release U4 and U1
  • spliceosomal B2 complex biosynthesis
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000388 - spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle