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Protein Overview: AAT2

General Information:
Name(s) found: AAT2 / YLR027C [SGD]
Description(s) found:
Found 16 descriptions.
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  • Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 418 amino acids

    Gene Ontology:
    Cellular Component: peroxisome [TASLink to PubMed article]
    cytoplasm [TASLink to PubMed article]
    Biological Process: glutamate metabolic process [NASLink to PubMed article]
    nitrogen compound metabolic process [NASLink to PubMed article]
    asparagine biosynthetic process from oxaloacetate [TAS]
    aspartate biosynthetic process [TAS]
    aspartate catabolic process [TAS]
    Molecular Function: L-aspartate:2-oxoglutarate aminotransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSATLFNNIE LLPPDALFGI KQRYGQDQRA TKVDLGIGAY RDDNGKPWVL PSVKAAEKLI  60
   61 HNDSSYNHEY LGITGLPSLT SNAAKIIFGT QSDAFQEDRV ISVQSLSGTG ALHISAKFFS 120
  121 KFFPDKLVYL SKPTWANHMA IFENQGLKTA TYPYWANETK SLDLNGFLNA IQKAPEGSIF 180
  181 VLHSCAHNPT GLDPTSEQWV QIVDAIASKN HIALFDTAYQ GFATGDLDKD AYAVRLGVEK 240
  241 LSTVSPVFVC QSFAKNAGMY GERVGCFHLA LTKQAQNKTI KPAVTSQLAK IIRSEVSNPP 300
  301 AYGAKIVAKL LETPELTEQW HKDMVTMSSR ITKMRHALRD HLVKLGTPGN WDHIVNQCGM 360
  361 FSFTGLTPQM VKRLEETHAV YLVASGRASI AGLNQGNVEY VAKAIDEVVR FYTIEAKL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AAT2 FUN30
    View Details Ho Y, et al. (2002) AAT2 ACH1 ACO1 ACS2 ADH4 AFR1 AHP1 ALA1 ARC1 ARF1 ARG4 ATP3 CAR2 CDC10 CDC11 CDC12 CDC3 CDC33 CDC60 CLU1 COF1 COR1 CPR1 CYR1 CYS4 DED81 EGD1 ENP1 ERG10 ERG13 ERG20 ERG6 FPR1 FRS2 GND1 GND2 GRS1 GRX1 GUS1 HEF3 HHF1, HHF2 HOM2 ILS1 LRO1 LSP1 MET6 MPC54 NAS6 NTF2 OLA1 OYE2 PDC5 PFK1 PIL1 PRM2 RNR2 RSN1 SAH1 SCP160 SEC53 SEN15 SES1 SHS1 SNU13 SOD1 SSZ1 SUI1 TEF4 THR4 THS1 TIF1, TIF2 TMA19 TPS1 TRR1 TSA2 UBA1 VMA4 VMA5 WTM1 YDL124W YNK1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen STE50 AAT2 1 Unpublished Fields Lab Data
    View Screen YLR224W AAT2 1 Unpublished Fields Lab Data
    View Screen SPT21 AAT2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data AAT2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..418] PSI-BLAST 76.0 Aspartate aminotransferase, AAT

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  6.52158261185762 bayes_pls_golite062009
  • phosphatidylserine decarboxylase activity
    		•  3.52333113038086 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  1.46601963907552 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  1.46601963907552 bayes_pls_golite062009
  • transferase activity
    		•  1.44093490824786 bayes_pls_golite062009
  • glutamate decarboxylase activity
    		•  1.34215658716536 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • 4-aminobutyrate transaminase activity
    		•  1.11017195698597 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.977210827616757 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.892872530648552 bayes_pls_golite062009
  • binding
    		•  0.892049641082766 bayes_pls_golite062009
  • N-succinyltransferase activity
    		•  0.87264568471543 bayes_pls_golite062009
  • DNA binding
    		•  0.803965264969424 bayes_pls_golite062009
  • N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
    		•  0.753443687983955 bayes_pls_golite062009
  • vitamin binding
    		•  0.66463470119531 bayes_pls_golite062009
  • transcription factor activity
    		•  0.597417107954964 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.50269055590758 bayes_pls_golite062009
  • alanine-glyoxylate transaminase activity
    		•  0.48682493494502 bayes_pls_golite062009
  • hydrolase activity
    		•  0.343938599116946 bayes_pls_golite062009
  • vitamin B6 binding
    		•  0.16957228630576 bayes_pls_golite062009
  • pyridoxal phosphate binding
    		•  0.16957228630576 bayes_pls_golite062009
  • ligase activity
    		•  0.103307018783573 bayes_pls_golite062009
  • aromatic-amino-acid:2-oxoglutarate aminotransferase activity
    		•  0.0916183433120769 bayes_pls_golite062009
  • cystathionine beta-lyase activity
    		•  0.0833010353195099 bayes_pls_golite062009
  • amine binding
    		•  0.00719250700539997 bayes_pls_golite062009
  • kynureninase activity
    		•  0.0041576792340694 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle