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Protein Overview: HSH49

General Information:
Name(s) found: HSH49 / YOR319W [SGD]
Description(s) found:
Found 28 descriptions.
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  • U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 213 amino acids

    Gene Ontology:
    Cellular Component: U2 snRNP [IDALink to PubMed articleLink to PubMed article]
    Biological Process: nuclear mRNA splicing, via spliceosome [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNYSADSGNT VYVGNIDPRI TKEQLYELFI QINPVLRIKY PKDKVLQAYQ GYAFIEFYNQ  60
   61 GDAQYAIKIM NNTVRLYDRL IKVRQVTNST GTTNLPSNIS KDMILPIAKL FIKNLADSID 120
  121 SDQLVKIFNK FGKLIREPEI FYLSNGKLKC AYVYFEDFEK ADLAIKSLNN QLVANNRITV 180
  181 DYAFKENGKG NAKYGDDVDR LLNKEALKHN MLK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CUS1 HSH155 HSH49 PRP11 PRP21 RSE1
    View Details Krogan NJ, et al. (2006) BUD13 BUD31 CUS1 CWC21 HSH155 HSH49 LEA1 LOT6 PRP11 PRP21 PRP45 PRP9 RSE1
    View Details Gavin AC, et al. (2006) CUS1 HSH155 HSH49 LEA1 MSL1 PRP11 PRP21 PRP9 RSE1
    View Details Gavin AC, et al. (2002) BRR1 CLF1 CSN12 CUS1 CWC2 DIB1 ECM2 HRT1 HSH155 HSH49 LEA1 LSM4 LUC7 MSL1 MUD1 PRP11 PRP19 PRP21 PRP3 PRP31 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP9 RSE1 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SNP1 SNT309 SNU114 SNU56 SNU66 SNU71 SPP382 SRB2 STO1
    View Details Ho Y, et al. (2002) CBF5 CHD1 CPR1 DBP7 EST1 FPR1 GDI1 HOM3 HSH49 KRE33 MLC2 MRM1 MSS116 PDI1 PUF6 PWP1 RPF2 RRP1 RRP12 RSE1 URB1 UTP10 YER077C
    View Details Qiu et al. (2008) CBC2 CEF1 CWC22 DIB1 HSH155 HSH49 IST3 LEA1 LSM4 LSM5 LUC7 MSL1 MUD1 NAM8 PRP11 PRP16 PRP18 PRP21 PRP28 PRP31 PRP39 PRP4 PRP40 PRP6 PRP8 PRP9 RSE1 SMB1 SMD1 SMX2 SNP1 SNU114 SNU23 SNU56 SNU71 SPP381 SYF2 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CWC2 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HSH49 LAC1 2 Unpublished Fields Lab Data
    View Screen TOS8 HSH49 2 Uetz P, et al. (2000)
    View Screen LSM8 HSH49 2 Uetz P, et al. (2000)
    View Screen HSH49 IRC15 2 Unpublished Fields Lab Data
    View Screen HSH49 SIF2 2 Uetz P, et al. (2000)
    View Screen HSH49 YPR015C 2 Unpublished Fields Lab Data
    View Screen HSH49 MTF2 2 Unpublished Fields Lab Data
    View Screen HSH49 GAL3 2 Unpublished Fields Lab Data
    View Screen HSH49 YGR226C 2 Unpublished Fields Lab Data
    View Screen HSH49 YJR141W 2 Unpublished Fields Lab Data
    View Screen HSH49 SPC42 1 Unpublished Fields Lab Data
    View Screen HSH49 TAF7 1 Unpublished Fields Lab Data
    View Screen HSH49 PDR18 1 Unpublished Fields Lab Data
    View Screen HSH49 CDC31 1 Unpublished Fields Lab Data
    View Screen HSH49 YPR076W 1 Unpublished Fields Lab Data
    View Screen HSH49 CCH1 1 Unpublished Fields Lab Data
    View Screen HSH49 YHL026C 1 Unpublished Fields Lab Data
    View Screen HSH49 PAN5 1 Unpublished Fields Lab Data
    View Screen HSH49 PEX18 1 Unpublished Fields Lab Data
    View Screen HSH49 MSL1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HSH49 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..88] PSI-BLAST 204.211549 Poly(A)-binding protein
    2 View Details [89..213] PSI-BLAST 204.211549 Poly(A)-binding protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
    		• 6.62953239642182 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.50398990564944 bayes_pls_golite062009
  • binding
    		•  4.16717332578111 bayes_pls_golite062009
  • snRNA binding
    		•  4.06596327298973 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • U1 snRNA binding
    		•  3.02511982045347 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.18211199677674 bayes_pls_golite062009
  • DNA binding
    		•  1.73925834998328 bayes_pls_golite062009
  • structural molecule activity
    		•  1.56454315220334 bayes_pls_golite062009
  • U2 snRNA binding
    		•  1.34078165372485 bayes_pls_golite062009
  • protein binding
    		•  1.10597581610211 bayes_pls_golite062009
  • transcription factor activity
    		•  0.873765500321315 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.294937517750882 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle